Maria Stamatin

Latest posts by Maria Stamatin (see all)

SUPRAVIETUIREA NOU-NASCUTILOR PREMATURI IN FUNCTIE DE NIVELUL DE ACORDARE A ASISTENTEI MEDICALE - 22/02/2017
THE SURVIVAL OF PREMATURE INFANTS DEPENDING ON THE LEVEL OF MEDICAL ASSISTANCE - 22/02/2017
COMPARAREA EFICIENTEI CAFEINEI VERSUS AMINOFILINA PENTRU TRATAMENTUL APNEEI DE PREMATURITATE - 30/05/2016

Articole semnate de acelasi autor in Revista Romana de Pediatrie:

SUPRAVIETUIREA NOU-NASCUTILOR PREMATURI IN FUNCTIE DE NIVELUL DE ACORDARE A ASISTENTEI MEDICALE

Revista Romana de PEDIATRIE | Volumul LXV, Nr. 4, An 2016

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Larisa Crivceanscaia, Maria Stamatin and Mihai Stratulat

REZUMAT

În întreaga lume, naştereа prematură este principala cauză a mortalităţii infantile şi o cauză semnificativă a pierderii potenţialului uman de prematuri supravieţuitori pentru următoarele etape de viaţă.
Obiectiv. Determinarea ratei de supravieţuire a nou-născuţilor prematuri în funcţie de nivelul de acordare a asistenţei medicale şi factorii de risc principali implicaţi în decesul nou-născuţilor prematuri cu termenul de gestaţie mai mic de 34 de săptămâni.
Material şi metodă. Au fost luaţi în studiu 750 de nou-născuţi prematuri repartizaţi în trei loturi astfel: lotul I – 476 de nou-născuţi prematuri din IMSP IMşiC Chişinău (maternitate de nivel III); lotul II – 240 de nou-născuţi prematuri transferaţi din maternităţi de nivel I şi II prin linia AVIASAN şi lotul III – 34 de nou-născuţi prematuri din IMSP IMşiC Chişinău cărora li s-a administrat surfactant prin metoda LISA (Less Invasive Surfactant Administration). S-a efectuat o analiză complexă privind factorii de risc pentru mortalitate şi impactul pozitiv al condiţiilor de îngrijire. Datele au fost analizate folosind soft-ul SPSS V.21. (IBM Statistical Package for the Social Sciences, Chicago, Illinois).
Rezultate. Rata de supravieţuire la 78 de zile de viaţă fost semnificativ mai mare în cazul nou-născuţilor proveniţi din maternităţi de nivel III, care au urmat terapie LISA (93,3%), comparativ cu nou-născuţii din loturile I (78,2%) şi II (78,9%).
Concluzii. Supravieţuirea nou-născuţilor prematuri este o problemă multifactorială. Factorul principal ce determină rata de deces a acestor nou-născuţi îl reprezintă sindromul de detresă respiratorie (SDR), fiind urmat de greutatea la naştere (GN), vârsta de gestaţie (VG), metoda de resuscitare, displazia bronhopulmonară (DBP) şi, nu în ultimul rând, nivelul maternităţii de provenienţă. Posibilităţile moderne de reanimare a prematurilor, din maternităţi de gradul III, cresc semnificativ speranţa de viaţă a prematurilor cu vârsta gestaţională mai mică de 34 de săptămâni.

Cuvinte cheie: nou-născut, supravieţuire, mortalitate, prematur

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Larisa Crivceanscaia

THE SURVIVAL OF PREMATURE INFANTS DEPENDING ON THE LEVEL OF MEDICAL ASSISTANCE

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Larisa Crivceanscaia, Maria Stamatin and Mihai Stratulat

ABSTRACT

Worldwide, premature birth is the main cause of infant mortality and a significant cause of human potential loss of premature survivors for the next stages of life.
Purpose. To determine the rate of premature infants survival depending on the level of medical assistance and the main risk factors involved in the death of preterm infants with gestational age less than 34 weeks.
Materials and methods. We included in the study 750 preterm newborns divided into three groups as follows: group 1 – 476 premature newborns born in IMSP IMsC, Chisinau (level III maternity); group 2 – 240 premature infants transferred by the AVIASAN service from level I and II maternities to the level III unit and group 3 – 34 premature babies from IMSP IMsC Chisinau that received surfactant administered by the LISA method (Less Invasive Surfactant Administration). We performed a complex analysis of the risk factors for death and the positive impact of highly specialised care on survival. The data was analysed using SPSS V.21 software (IBM Statistical Package for the Social Sciences, Chicago, Illinois).
Results. The survival rate at 78 days of life was significantly higher in the newborns from the level III maternity that received LISA therapy (93.3%), compared to those in group 1 (78.2%) and group 2 (78.9%) respectively.
Conclusions. The survival of premature infants is a multifactorial problem. The main factor that determines the rate of death for these infants is respiratory distress syndrome (RDS), followed by birth weight (BW), gestational age (GA), resuscitation method, bronchopulmonary dysplasia (BPD) and last but not least by the level of maternity where the infants were born. These factors might be considered predictive for death of preterm newborns with gestational age less than 34 weeks.

Keywords: newborn, survival, mortality, premature

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Larisa Crivceanscaia

COMPARAREA EFICIENTEI CAFEINEI VERSUS AMINOFILINA PENTRU TRATAMENTUL APNEEI DE PREMATURITATE

Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 4, An 2015

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Gabriela Ildiko Zonda, Andreea Avasiloaiei, Mihaela Moscalu and Maria Stamatin

REZUMAT

Scop. Evaluarea eficienţei cafeinei comparativ cu aminofilina în tratamentul apneei de prematuritate.

Material şi metodă. Am realizat un studiu retrospectiv comparativ pe două loturi de nou-născuţi prematuri admişi în Centrul Regional de Terapie Intensivă Neonatală din cadrul Spitalului Clinic de Obstetrică şi Ginecologie „Cuza-Vodă“, Iaşi, în perioada iunie 2012 – iunie 2015.

Rezultate. La nou-născuţii care au primit cafeină s-a înregistrat o reducere semnificativă statistic a numărului crizelor de apnee în ziua a 3-a, respectiv a 14-a de tratament comparativ cu cei care au fost trataţi cu aminofilină. Tratamentul cu cafeină s-a asociat o uşoară scădere a necesităţii instituirii CPAP şi a ventilaţiei mecanice comparativ cu aminofilina, dar diferenţele nu au fost semnificative statistic. Anemia, hemoragia intraventriculară, per sistenţa de canal arterial şi boala pulmonară cronică s-au corelat cu creşterea duratei tratamentului pentru apnee de prematuritate. Nou-născuţii din lotul cu cafeină au prezentat mai multe episoade de agitaţie, tahicardie şi intoleranţă digestivă, însă o incidenţă mai mică a enterocolitei ulcero-necrotice, a scăderii ponderale şi a HTA, faţă de cei care au primit aminofilină. Durata de spitalizare a fost mai redusă la nou-născuţii trataţi cu cafeină, comparativ cu cei din lotul cu aminofilină.

Concluzii. Avantajele terapeutice ale cafeinei sunt remarcabile prin incidenţa scăzută a efectelor adverse semnificative şi raportul cost/beneficiu pe termen lung, pledând pentru recomandarea acesteia ca tratament de elecţie pentru apneea de prematuritate. Aceste aspecte justifică iniţierea unui studiu multicentric la nivel naţional care să includă un număr mult mai semnificativ de nou-născuţi prematuri pentru evaluarea eficienţei tratamentului cu cafeină la toate categoriile de vârstă gestaţională.

Cuvinte cheie: apnee, prematuritate, metilxantine, cafeină

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Gabriela Ildiko Zonda

COMPARISON OF THE EFFICIENCY OF CAFFEINE VERSUS AMINOPHYLLINE FOR THE TREATMENT OF APNOEA OF PREMATURITY

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Gabriela Ildiko Zonda, Andreea Avasiloaiei, Mihaela Moscalu and Maria Stamatin

ABSTRACT

Purpose. Comparison of the efficiency of caffeine and aminophylline for the treatment of apnoea in premature neonates.

Material and method. We conducted a retrospective study on two lots of premature infants admitted in the Regional Centre of Neonatal Intensive Care Unit of the “Cuza-Vodă” Clinical Hospital of Obstetrics and Gynaecology of Iasi during June 2012 – June 2015.

Results. Neonates treated with caffeine had significantly less apnoea on day 3 and 14 of treatment comparing with those who received aminophylline. Caffeine treatment was associated with less need for CPAP and mechanical ventilation comparing with aminophylline, but there was no statistical significance. Anemia, intraventricular hemorrhage, persistent ductus arteriosus and chronic lung disease were correlated with an increased duration of the treatment for apnoea of prematurity. Neonates from the caffeine group had more episodes of agitation, tachycardia and digestive intolerance, but at the same time a reduced incidence of necrotizing enterocolitis, weight loss and hypertension, compared to those from the aminophylline group. The hospital stay duration was reduced in the infants that received caffeine treatment compared to those that received aminophylline.

Conclusion. The therapeutic advantages of caffeine are remarkable due to low incidence of significant adverse effects and its long-term cost/efficiency ratio, which recommend it as the best treatment for apnoea of prematurity. These facts justify the initiation of a multicentre national study including a higher number of premature neonates for the evaluation of the efficiency of caffeine therapy in all gestational age groups.

Keywords: apnoea, prematurity, methylxanthines, caffeine

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Gabriela Ildiko Zonda

ASPECTE ETICE PRIVIND RECOLTAREA SANGELUI DIN CORDONUL OMBILICAL IN SCOP DIAGNOSTIC

Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 3, An 2015

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Elena Tataranu, Maria Stamatin, Smaranda Diaconescu, Angelica Cristina Marin, Cornelia Savescu and Marin Burlea

REZUMAT

Aprofundarea studiilor privind mecanismele genetice şi epigenetice (determinate de mediu) ale atopiei a adus dezvăluiri privind debutul intrauterin al alergiei, dovedit de prezenţa IgE în sângele cordonului ombilical. Depistarea acestor nou-născuţi şi includerea lor într-un program de îngrijiri specifice reduc morbiditatea ulterioară din cadrul marşului alergic cu efecte incontestabile asupra calităţii vieţii şi a costurilor de îngrijire medicală. Creşterea dramatică a prevalenţei atopiei în ultimele decenii sugerează importanţa determinărilor IgE în cordonul ombilical. Utilizarea în scop diagnostic a sângelui cordonului ombilical impune însă legi şi reguli clare care fac obiectul dezbaterii din prezenta lucrare.

Cuvine cheie: consimţământ informat, sânge din cordon ombilical, atopie, IgE

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Elena Tataranu

ETHICAL ASPECTS ABOUT INFORMED CONSENT IN CORD BLOOD COLLECTION FOR DIAGNOSTIC PURPOSES

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Elena Tataranu, Maria Stamatin, Smaranda Diaconescu, Angelica Cristina Marin, Cornelia Savescu and Marin Burlea

ABSTRACT

Deepening the knowledge about genetic and epigenetic mechanisms studies (environmental caused) regarding atopy, brought revelations about intrauterine onset of allergies, proven by the presence of IgE in umbilical cord blood. Detection of these newborns and their inclusion in a specific care program further reduces the morbidity of allergic march with the undeniable effects on quality of life and healthcare costs. The dramatic increase in the prevalence of atopy in recent decades suggests the importance of IgE in umbilical cord determinations. The use of umbilical cord blood for diagnostic purposes requires clear laws and rules and this is the subject we suggest to debate in this paper.

Keywords: informed consent, cord blood, atopy, IgE

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Elena Tataranu

Perinatal asphyxia – underlying mechanisms and targeted therapeutic strategies

Revista Romana de PEDIATRIE | Volumul LXI, Nr. 2, An 2012

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Andreea Avasiloaiei and Maria Stamatin

ABSTRACT

Perinatal asphyxia complicated with multiorganic hypoxic-ischaemic injuries represents, despite current advances in neonatal medicine, the leading cause of morbidity and mortality in both term and premature newborns. The mechanisms of neuronal damage are heterogeneous and include the participation of circulatory, metabolic and biochemical factors. In the early stage, therapies are concentrated on prevention of the production of reactive oxygen species or free radicals, anti-inflammatory effects and anti-apoptotic interventions. In a later stage stimulation of neurotrophic properties in the neonatal brain can be targeted to promote neuronal and oligodendrocyte regeneration.

Key words: perinatal asphyxia, neuronal injury, neuroprotective strategies

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Andreea Avasiloaiei

ASFIXIA PERINATALA – MECANISME DE PRODUCERE SI STRATEGII TERAPEUTICE TINTITE

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Andreea Avasiloaiei and Maria Stamatin

REZUMAT

Asfixia perinatală complicată cu leziuni hipoxic-ischemice multiorganice reprezintă, în pofida progreselor actuale din medicina neonatală, cea mai importantă cauză de morbiditate şi mortalitate perinatală la nounăscutul la termen şi prematur. Mecanismele lezionale sunt heterogene şi au loc cu participarea factorilor etiologici circulatori, metabolici şi biochimici. În primele momente de după injurie, tratamentul se concentrează pe prevenirea formării radicalilor liberi, combaterea inflamaţiei şi efectele anti-apoptotice. În stadiile tardive, se urmăreşte regenerarea oligodendrogliei prin utilizarea medicaţiei cu efect neurotrofic.

Cuvinte cheie: asfixie perinatală, leziune neuronală, strategii de neuroprotecţie

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Andreea Avasiloaiei

ENTEROCOLITA ULCERO-NECROTICA: DATE CLINICE SI POSIBILITATI DE TRATAMENT

Revista Romana de PEDIATRIE | Volumul LXIII, Nr. 4, An 2014

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Elena Hanganu, Maria Stamatin, S.G. Aprodu, Mihaela Moscalu and Simona Gavrilescu

ABSTRACT

Obiective. Identificarea corelaţiilor între evoluţia clinică a nou-născuţilor cu enterocolita ulceronecrotică (EUN) şi stadiul de boală, factorii de risc asociaţi, respectiv tipul de tratament utilizat.

Material şi metodă. S-a realizat un studiu retrospectiv pe o perioadă de 6 ani pe baza cazuisticii Centrului Regional de Terapie Intensivă Neonatală „Cuza Voda“ şi s-au identificat 205 cazuri de enterocolită ulceronecrotică dintr-un total de 6.183 de nou-născuţi îngrijiţi aici. Bolnavii au fost împărţiţi în loturi de studiu în funcţie de vârsta de gestaţie (VG), respectiv greutatea la naştere (GN). Protocolul de analiză s-a realizat pe baza unei fişe de lucru care a cuprins datele epidemiologice ale pacienţilor, factorii de risc, tipul alimentaţiei, vârstă în momentul diagnosticului, stadiul de boală conform clasificării Bell, modalitatea de tratament (medical, chirurgical sau mixt), complicaţiile înregistrate şi evoluţia pacienţilor. Prelucrarea statistică a datelor s-a făcut utilizând programul SPSS Statistics 20.

Rezultate. Enterocolita ulceronecrotică a avut o frecvenţă de 3,3% în lotul studiat şi a fost diagnosticată la nounăscuţii prematuri în 75,6% dintre cazuri. VG medie în grupul de studiu a fost de 33 săptămâni. GN medie a fost de 1.896 g, cu 43% dintre cazuri în grupul cu greutate foarte mică la naştere (VLBW) şi 31,2% în grupul cu greutate mică la naştere (LBW). Incidenţa procentuală a factorilor de risc a fost următoarea în ordinea frecvenţei: persistenţa canalului arterial 19,5%, asfixia perinatală 13,7%, detresa respiratorie 100% dintre cazuri. 75,5% dintre cazuri au fost tratate şi externate din CRTIN, 16,6% dintre cazuri au fost transferate în Clinica de Chirurgie Pediatrică a Spitalului „Sf. Maria“ şi 3,9% au decedat la CRTIN. Din cele 34 de cazuri transferate, 19 cazuri au fost tratate chirurgical: 8 cazuri cu drenaj peritoneal (DP), 8 cazuri cu laparotomie primara (LAP) şi 3 cazuri cu LAP şi DP. Rata supravieţuirii în acest grup a fost 2,4%, iar pentru grupul cu tratament medical a fost 4,9%.

Concluzii. Prematuritatea se corelează statistic cu stadii avansate de enterocolită în momentul diagnosticului. Modalitatea de tratament chirurgical aleasă (drenaj peritoneal sau laparotomie) nu influenţează rezultatele, iar alimentaţia enterală precoce cu formula de lapte este cel mai important factor de risc pentru apariţia EUN, urmat de vârsta de gestaţie şi greutatea foarte mică la naştere.

Cuvinte cheie: enterocolită ulceronecrotică, nou-născut, posibilităţi de tratament

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Elena Hanganu

NEONATAL NECROTIZING ENTEROCOLITIS: CLINICAL DATA AND TREATMENT POSSIBILITIES

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Elena Hanganu, Maria Stamatin, S.G. Aprodu, Mihaela Moscalu and Simona Gavrilescu

ABSTRACT

Objectives. The aim of this paper is to identify the correlations between the clinical evolution of the neonates with necrotizing enterocolitis (NEC) and the stage of disease, associated risk factors and the type of treatment used.

Material and methods. A 6 years retrospective study was performed based on reviewing the casuistry of the Regional Centre of Neonatal Intensive Care Unit (NICU) „Cuza Voda” and 205 cases of necrotizing enterocolitis were identified from a total number of 6183 neonates admitted there. Patients were divided in to study groups based on the gestational age (GA) and birth weight (BW). The analysis protocol was realized based on a working sheet that included the epidemiological data of the patients, the risk factors, type of nutrition, age at diagnosis, stage of disease according to Bell classification, type of treatment (medical, surgical or combined), complications and the general evolution. The statistical data processing was performed in SPSS Statistics 20 program.

Results. NEC had a frequency of 3.3% is the study group and was diagnosed in premature newborns in 75.6% of cases. The mean GA for the study group was 33 weeks. The mean BW was 1896 g with 43% of the cases in very low birth weight (VLBW) group and 31.2% in low birth weight (LBW) group. The percentage incidence of the risk factors was as follows: persistence of ductusarteriossus 19.5%, perinatal asphyxia 13.7% and respiratory distress 100% of cases. 75.5% were treated and discharged from NICU, 16.6% were transferred to Pediatric Surgery Department „Sf. Maria” and 3.9% died in NICU. From the 34 cases transferred19 cases were surgically treated: 8 cases with peritoneal drainage (PD), 8 cases with primary laparotomy (LAP) and 3 cases with PD and LAP. The survival rate in this group was 2.4% and for the medically treated group was 4.9%.

Conclusions. Prematurity is statistically correlated with encountering advanced stages of enterocolitis at the time of diagnosis. The option for surgical treatment (peritoneal drainage or laparotomy) does not influence the results and early enteral feeding with formula is the most important risk factor for NEC followed by age of gestation and very low birth weight.

Keywords: necrotizing enterocolitis, newborn, treatment possibilities

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Elena Hanganu

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