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Perinatal asphyxia – underlying mechanisms and targeted therapeutic strategies
Perinatal asphyxia complicated with multiorganic hypoxic-ischaemic injuries represents, despite current advances in neonatal medicine, the leading cause of morbidity and mortality in both term and premature newborns. The mechanisms of neuronal damage are heterogeneous and include the participation of circulatory, metabolic and biochemical factors. In the early stage, therapies are concentrated on prevention of the production of reactive oxygen species or free radicals, anti-inflammatory effects and anti-apoptotic interventions. In a later stage stimulation of neurotrophic properties in the neonatal brain can be targeted to promote neuronal and oligodendrocyte regeneration.
Key words: perinatal asphyxia, neuronal injury, neuroprotective strategies