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Andreea Avasiloaiei

Latest posts by Andreea Avasiloaiei (see all)

  • COMPARAREA EFICIENTEI CAFEINEI VERSUS AMINOFILINA PENTRU TRATAMENTUL APNEEI DE PREMATURITATE - 30/05/2016
  • COMPARISON OF THE EFFICIENCY OF CAFFEINE VERSUS AMINOPHYLLINE FOR THE TREATMENT OF APNOEA OF PREMATURITY - 30/05/2016
  • Perinatal asphyxia – underlying mechanisms and targeted therapeutic strategies - 28/07/2015

Articole semnate de acelasi autor in Revista Romana de Pediatrie:

COMPARAREA EFICIENTEI CAFEINEI VERSUS AMINOFILINA PENTRU TRATAMENTUL APNEEI DE PREMATURITATE

SELECT ISSUE

Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 4, An 2015
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

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DOAJ
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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

COMPARAREA EFICIENTEI CAFEINEI VERSUS AMINOFILINA PENTRU TRATAMENTUL APNEEI DE PREMATURITATE

Gabriela Ildiko Zonda, Andreea Avasiloaiei, Mihaela Moscalu and Maria Stamatin

REZUMAT

Scop. Evaluarea eficienţei cafeinei comparativ cu aminofilina în tratamentul apneei de prematuritate.

Material şi metodă. Am realizat un studiu retrospectiv comparativ pe două loturi de nou-născuţi prematuri admişi în Centrul Regional de Terapie Intensivă Neonatală din cadrul Spitalului Clinic de Obstetrică şi Ginecologie „Cuza-Vodă“, Iaşi, în perioada iunie 2012 – iunie 2015.

Rezultate. La nou-născuţii care au primit cafeină s-a înregistrat o reducere semnificativă statistic a numărului crizelor de apnee în ziua a 3-a, respectiv a 14-a de tratament comparativ cu cei care au fost trataţi cu aminofilină. Tratamentul cu cafeină s-a asociat o uşoară scădere a necesităţii instituirii CPAP şi a ventilaţiei mecanice comparativ cu aminofilina, dar diferenţele nu au fost semnificative statistic. Anemia, hemoragia intraventriculară, per sistenţa de canal arterial şi boala pulmonară cronică s-au corelat cu creşterea duratei tratamentului pentru apnee de prematuritate. Nou-născuţii din lotul cu cafeină au prezentat mai multe episoade de agitaţie, tahicardie şi intoleranţă digestivă, însă o incidenţă mai mică a enterocolitei ulcero-necrotice, a scăderii ponderale şi a HTA, faţă de cei care au primit aminofilină. Durata de spitalizare a fost mai redusă la nou-născuţii trataţi cu cafeină, comparativ cu cei din lotul cu aminofilină.

Concluzii. Avantajele terapeutice ale cafeinei sunt remarcabile prin incidenţa scăzută a efectelor adverse semnificative şi raportul cost/beneficiu pe termen lung, pledând pentru recomandarea acesteia ca tratament de elecţie pentru apneea de prematuritate. Aceste aspecte justifică iniţierea unui studiu multicentric la nivel naţional care să includă un număr mult mai semnificativ de nou-născuţi prematuri pentru evaluarea eficienţei tratamentului cu cafeină la toate categoriile de vârstă gestaţională.

Cuvinte cheie: apnee, prematuritate, metilxantine, cafeină

Full text | PDF

Gabriela Ildiko Zonda

COMPARISON OF THE EFFICIENCY OF CAFFEINE VERSUS AMINOPHYLLINE FOR THE TREATMENT OF APNOEA OF PREMATURITY

SELECT ISSUE

Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 4, An 2015
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

COMPARISON OF THE EFFICIENCY OF CAFFEINE VERSUS AMINOPHYLLINE FOR THE TREATMENT OF APNOEA OF PREMATURITY

Gabriela Ildiko Zonda, Andreea Avasiloaiei, Mihaela Moscalu and Maria Stamatin

ABSTRACT

Purpose. Comparison of the efficiency of caffeine and aminophylline for the treatment of apnoea in premature neonates.

Material and method. We conducted a retrospective study on two lots of premature infants admitted in the Regional Centre of Neonatal Intensive Care Unit of the “Cuza-Vodă” Clinical Hospital of Obstetrics and Gynaecology of Iasi during June 2012 – June 2015.

Results. Neonates treated with caffeine had significantly less apnoea on day 3 and 14 of treatment comparing with those who received aminophylline. Caffeine treatment was associated with less need for CPAP and mechanical ventilation comparing with aminophylline, but there was no statistical significance. Anemia, intraventricular hemorrhage, persistent ductus arteriosus and chronic lung disease were correlated with an increased duration of the treatment for apnoea of prematurity. Neonates from the caffeine group had more episodes of agitation, tachycardia and digestive intolerance, but at the same time a reduced incidence of necrotizing enterocolitis, weight loss and hypertension, compared to those from the aminophylline group. The hospital stay duration was reduced in the infants that received caffeine treatment compared to those that received aminophylline.

Conclusion. The therapeutic advantages of caffeine are remarkable due to low incidence of significant adverse effects and its long-term cost/efficiency ratio, which recommend it as the best treatment for apnoea of prematurity. These facts justify the initiation of a multicentre national study including a higher number of premature neonates for the evaluation of the efficiency of caffeine therapy in all gestational age groups.

Keywords: apnoea, prematurity, methylxanthines, caffeine

Full text | PDF

Gabriela Ildiko Zonda

Perinatal asphyxia – underlying mechanisms and targeted therapeutic strategies

SELECT ISSUE

Revista Romana de PEDIATRIE | Volumul LXI, Nr. 2, An 2012
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Perinatal asphyxia – underlying mechanisms and targeted therapeutic strategies

Andreea Avasiloaiei and Maria Stamatin

ABSTRACT

Perinatal asphyxia complicated with multiorganic hypoxic-ischaemic injuries represents, despite current advances in neonatal medicine, the leading cause of morbidity and mortality in both term and premature newborns. The mechanisms of neuronal damage are heterogeneous and include the participation of circulatory, metabolic and biochemical factors. In the early stage, therapies are concentrated on prevention of the production of reactive oxygen species or free radicals, anti-inflammatory effects and anti-apoptotic interventions. In a later stage stimulation of neurotrophic properties in the neonatal brain can be targeted to promote neuronal and oligodendrocyte regeneration.

Key words: perinatal asphyxia, neuronal injury, neuroprotective strategies

Full text | PDF

Andreea Avasiloaiei

ASFIXIA PERINATALA – MECANISME DE PRODUCERE SI STRATEGII TERAPEUTICE TINTITE

SELECT ISSUE

Revista Romana de PEDIATRIE | Volumul LXI, Nr. 2, An 2012
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

ASFIXIA PERINATALA – MECANISME DE PRODUCERE SI STRATEGII TERAPEUTICE TINTITE

Andreea Avasiloaiei and Maria Stamatin

REZUMAT

Asfixia perinatală complicată cu leziuni hipoxic-ischemice multiorganice reprezintă, în pofida progreselor actuale din medicina neonatală, cea mai importantă cauză de morbiditate şi mortalitate perinatală la nounăscutul la termen şi prematur. Mecanismele lezionale sunt heterogene şi au loc cu participarea factorilor etiologici circulatori, metabolici şi biochimici. În primele momente de după injurie, tratamentul se concentrează pe prevenirea formării radicalilor liberi, combaterea inflamaţiei şi efectele anti-apoptotice. În stadiile tardive, se urmăreşte regenerarea oligodendrogliei prin utilizarea medicaţiei cu efect neurotrofic.

Cuvinte cheie: asfixie perinatală, leziune neuronală, strategii de neuroprotecţie

Full text | PDF

Andreea Avasiloaiei


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