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Mihaela Moscalu

Latest posts by Mihaela Moscalu (see all)

  • DIAGNOSTIC SI TRATAMENT IN BOALA DE REFLUX GASTROESOFAGIAN – POSIBILITATI SI LIMITE - 03/11/2016
  • DIAGNOSIS AND TREATMENT IN GASTROESOPHAGEAL REFLUX DISEASE – POSSIBILITIES AND LIMITATIONS - 03/11/2016
  • COMPARAREA EFICIENTEI CAFEINEI VERSUS AMINOFILINA PENTRU TRATAMENTUL APNEEI DE PREMATURITATE - 30/05/2016

Articole semnate de acelasi autor in Revista Romana de Pediatrie:

DIAGNOSTIC SI TRATAMENT IN BOALA DE REFLUX GASTROESOFAGIAN – POSIBILITATI SI LIMITE

SELECT ISSUE

Revista Romana de PEDIATRIE | Volumul LXV, Nr. 3, An 2016
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

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Promoting Global Health

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DIAGNOSTIC SI TRATAMENT IN BOALA DE REFLUX GASTROESOFAGIAN – POSIBILITATI SI LIMITE

Angelica Cristina Marin, Claudia Olaru, Gabriela Ciubotariu, Marin Burlea, Mihaela Moscalu, Nicoleta Gimiga and Smaranda Diaconescu

REZUMAT

Departajarea refluxului gastro-esofagian (RGE) fiziologic (cel mai frecvent) de boala de reflux gastro-esofagian (BRGE) în primul an de viaţă este obligatorie pentru a evita farmacoterapia agresivă. La toate vârstele
copilăriei se aplică criterii moderne de evaluare clinică, sumând simptome digestive şi/sau extradigestive şi rezultatele unor investigaţii moderne. Tratamentul igieno-dietetic (suficient in RGE fiziologic), obligatoriu în toate cazurile, şi inhibitorii de pompă protonică dupa vârsta de un an induc remisiune în majoritatea cazurilor de RGE. Evoluţia cronică/recidivantă şi rezistenţa la tratamentul comun impun intervenţia chirurgicală, domeniu îmbogaţit recent la copil cu miotomia perorală endoscopică (POEM).

Cuvinte cheie: boală de reflux gastroesofagian, inhibitori de pompă de protoni, miotomia perorală endoscopică

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Angelica Cristina Marin

DIAGNOSIS AND TREATMENT IN GASTROESOPHAGEAL REFLUX DISEASE – POSSIBILITIES AND LIMITATIONS

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Revista Romana de PEDIATRIE | Volumul LXV, Nr. 3, An 2016
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

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DIAGNOSIS AND TREATMENT IN GASTROESOPHAGEAL REFLUX DISEASE – POSSIBILITIES AND LIMITATIONS

Angelica Cristina Marin, Claudia Olaru, Gabriela Ciubotariu, Marin Burlea, Mihaela Moscalu, Nicoleta Gimiga and Smaranda Diaconescu

ABSTRACT

In children’s first year of life it is mandatory to make a difference between physiological gastroesophageal reflux (GER) and gastroesophageal reflux disease (GERD), in order to avoid an aggressive pharmacologic therapy. All ages of childhood benefit from modern criteria of clinical evaluation, by corroborating the digestive or extradigestive symptoms with the results of modern investigations. The dietary measures (sufficient in GER but mandatory in all cases) together with proton pump inhibitors administration after one year of age induce remission in majority of GER cases. The chronic and recurrent evolution of the disease or failure of the common treatment require surgical intervention, recently enriched in children with peroral endoscopic myotomy (POEM).

Keywords: gastroesophageal reflux disease, proton pump inhibitors, Peroral Endoscopic Myotomy

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Angelica Cristina Marin

COMPARAREA EFICIENTEI CAFEINEI VERSUS AMINOFILINA PENTRU TRATAMENTUL APNEEI DE PREMATURITATE

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Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 4, An 2015
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

COMPARAREA EFICIENTEI CAFEINEI VERSUS AMINOFILINA PENTRU TRATAMENTUL APNEEI DE PREMATURITATE

Gabriela Ildiko Zonda, Andreea Avasiloaiei, Mihaela Moscalu and Maria Stamatin

REZUMAT

Scop. Evaluarea eficienţei cafeinei comparativ cu aminofilina în tratamentul apneei de prematuritate.

Material şi metodă. Am realizat un studiu retrospectiv comparativ pe două loturi de nou-născuţi prematuri admişi în Centrul Regional de Terapie Intensivă Neonatală din cadrul Spitalului Clinic de Obstetrică şi Ginecologie „Cuza-Vodă“, Iaşi, în perioada iunie 2012 – iunie 2015.

Rezultate. La nou-născuţii care au primit cafeină s-a înregistrat o reducere semnificativă statistic a numărului crizelor de apnee în ziua a 3-a, respectiv a 14-a de tratament comparativ cu cei care au fost trataţi cu aminofilină. Tratamentul cu cafeină s-a asociat o uşoară scădere a necesităţii instituirii CPAP şi a ventilaţiei mecanice comparativ cu aminofilina, dar diferenţele nu au fost semnificative statistic. Anemia, hemoragia intraventriculară, per sistenţa de canal arterial şi boala pulmonară cronică s-au corelat cu creşterea duratei tratamentului pentru apnee de prematuritate. Nou-născuţii din lotul cu cafeină au prezentat mai multe episoade de agitaţie, tahicardie şi intoleranţă digestivă, însă o incidenţă mai mică a enterocolitei ulcero-necrotice, a scăderii ponderale şi a HTA, faţă de cei care au primit aminofilină. Durata de spitalizare a fost mai redusă la nou-născuţii trataţi cu cafeină, comparativ cu cei din lotul cu aminofilină.

Concluzii. Avantajele terapeutice ale cafeinei sunt remarcabile prin incidenţa scăzută a efectelor adverse semnificative şi raportul cost/beneficiu pe termen lung, pledând pentru recomandarea acesteia ca tratament de elecţie pentru apneea de prematuritate. Aceste aspecte justifică iniţierea unui studiu multicentric la nivel naţional care să includă un număr mult mai semnificativ de nou-născuţi prematuri pentru evaluarea eficienţei tratamentului cu cafeină la toate categoriile de vârstă gestaţională.

Cuvinte cheie: apnee, prematuritate, metilxantine, cafeină

Full text | PDF

Gabriela Ildiko Zonda

COMPARISON OF THE EFFICIENCY OF CAFFEINE VERSUS AMINOPHYLLINE FOR THE TREATMENT OF APNOEA OF PREMATURITY

SELECT ISSUE

Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 4, An 2015
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

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ICMJE- Recommendations

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Promoting Global Health

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COMPARISON OF THE EFFICIENCY OF CAFFEINE VERSUS AMINOPHYLLINE FOR THE TREATMENT OF APNOEA OF PREMATURITY

Gabriela Ildiko Zonda, Andreea Avasiloaiei, Mihaela Moscalu and Maria Stamatin

ABSTRACT

Purpose. Comparison of the efficiency of caffeine and aminophylline for the treatment of apnoea in premature neonates.

Material and method. We conducted a retrospective study on two lots of premature infants admitted in the Regional Centre of Neonatal Intensive Care Unit of the “Cuza-Vodă” Clinical Hospital of Obstetrics and Gynaecology of Iasi during June 2012 – June 2015.

Results. Neonates treated with caffeine had significantly less apnoea on day 3 and 14 of treatment comparing with those who received aminophylline. Caffeine treatment was associated with less need for CPAP and mechanical ventilation comparing with aminophylline, but there was no statistical significance. Anemia, intraventricular hemorrhage, persistent ductus arteriosus and chronic lung disease were correlated with an increased duration of the treatment for apnoea of prematurity. Neonates from the caffeine group had more episodes of agitation, tachycardia and digestive intolerance, but at the same time a reduced incidence of necrotizing enterocolitis, weight loss and hypertension, compared to those from the aminophylline group. The hospital stay duration was reduced in the infants that received caffeine treatment compared to those that received aminophylline.

Conclusion. The therapeutic advantages of caffeine are remarkable due to low incidence of significant adverse effects and its long-term cost/efficiency ratio, which recommend it as the best treatment for apnoea of prematurity. These facts justify the initiation of a multicentre national study including a higher number of premature neonates for the evaluation of the efficiency of caffeine therapy in all gestational age groups.

Keywords: apnoea, prematurity, methylxanthines, caffeine

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Gabriela Ildiko Zonda

IMPACTUL INFECTIEI CU STAPHYLOCOCCUS AUREUS ASUPRA EVOLUTIEI FIBROZEI CHISTICE LA COPIII DINTR-UN CENTRU REGIONAL DIN NORD-ESTUL ROMANIEI

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Revista Romana de PEDIATRIE | Volumul LXIII, Nr. 2, An 2014
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

IMPACTUL INFECTIEI CU STAPHYLOCOCCUS AUREUS ASUPRA EVOLUTIEI FIBROZEI CHISTICE LA COPIII DINTR-UN CENTRU REGIONAL DIN NORD-ESTUL ROMANIEI

Dana-Teodora Anton-Paduraru, Mihaela Moscalu, Gabriela Coman, Laura Florescu and Laura-Mihaela Trandafir

REZUMAT

Introducere. Infecţiile bacteriene cronice şi, adesea, exacerbările infecţioase acute sunt caracteristice bolii pulmonare din fibroza chistică (FC). Obiectivul studiului a fost reprezentat de identificarea copiilor cu FC, depistarea infecţiei cu Staphylococcus aureus la aceşti bolnavi şi cuantificarea impactului infecţiei asupra statusului clinic.

Material şi metodă. S-a realizat un studiu prospectiv pe o perioadă de 3 ani pe un lot de 37 de copii cu FC aflaţi în evidenţa Centrului Regional din Clinica III Pediatrie Iaşi, România. La aceşti bolnavi s-a urmărit prezenţa S. aureus, prevalenţa tulpinilor de S.aureus meticilino-rezistente (SAMR), impactul infecţiei cronice cu SAMR asupra funcţiei pulmonare concomitent cu prezenţa unor elemente de severitate în FC.

Rezultate. 22 de pacienţi dintre cei 37 cu FC au prezentat culturi pozitive pentru S. aureus; la 9 dintre aceştia s-a izolat SAMR, 5 având infecţie cronică. Grupul SAMR pozitiv a prezentat valori semnificativ mai mici ale volumului de gaz expirat în prima secundă a expirului forţat (FEV1), status nutriţional mai precar, bronşiectazii severe, un număr mai mare de exacerbări pulmonare şi implicit de spitalizări, insuficienţă pancreatică în majoritatea cazurilor şi o asociere mai mare cu genotipul F508del.

Concluzii. S. aureus rămâne un patogen important în FC. Din cauza patogenicităţii sale crescute, S. aureus şi în special tulpinile SAMR pot contribui la evoluţie clinică nefavorabilă.

Cuvinte cheie: fibroză chistică, copil, Staphylococcus aureus

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Dana-Teodora Anton-Paduraru

THE IMPACT OF THE STAPHYLOCOCCUS AUREUS INFECTION ON THE EVOLUTION OF CHILDREN WITH CYSTIC FIBROSIS FROM A REGIONAL CENTRE IN NORTH-EASTERN ROMANIA

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Revista Romana de PEDIATRIE | Volumul LXIII, Nr. 2, An 2014
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

THE IMPACT OF THE STAPHYLOCOCCUS AUREUS INFECTION ON THE EVOLUTION OF CHILDREN WITH CYSTIC FIBROSIS FROM A REGIONAL CENTRE IN NORTH-EASTERN ROMANIA

Dana-Teodora Anton-Paduraru, Mihaela Moscalu, Gabriela Coman, Laura Florescu and Laura-Mihaela Trandafir

ABSTRACT

Introduction. Chronic bacterial infections and – often – acute infectious exacerbations are characteristic to the lung disease of the cystic fibrosis (CF). The objective of this study was to identify children with CF and Staphylococcus aureus infection and quantify the impact of this infection on their clinical status.

Material and methods. A prospective study was carried out during 3 years on a batch of 37 children with CF registered in the records of the Regional Monitoring Centre of the 3rd Clinic of Pediatrics of Iasi, Romania. In these patients, we searched for the presence of S. aureus, the prevalence of methicillin-resistant S. aureus (MRSA) strains, the impact of the chronic infection with MRSA on the lung function concomitant with the presence of severity elements in CF.

Results. 22 of the 37 patients with CF had positive culture for S. Aureus; at 9 of them was isolated MRSA and 5 had chronic infection. The MRSA positive group of patients presented signifi cantly lower values of the FEV1, a more poor nutritional status, severe bronchiectases, a larger number of pulmonary exacerbations and implicitly hospitalizations, pancreatic insufficiency in most cases and a higher degree of association with the F508del genotype.

Conclusions. S. aureus remains an important pathogen in CF. Due to its high pathogeny, S. aureus and especially the MRSA strains can contribute to an unfavourable clinical evolution.

Keywords: cystic fibrosis, children, Staphylococcus aureus

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Dana-Teodora Anton-Paduraru

ENTEROCOLITA ULCERO-NECROTICA: DATE CLINICE SI POSIBILITATI DE TRATAMENT

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Revista Romana de PEDIATRIE | Volumul LXIII, Nr. 4, An 2014
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

ENTEROCOLITA ULCERO-NECROTICA: DATE CLINICE SI POSIBILITATI DE TRATAMENT

Elena Hanganu, Maria Stamatin, S.G. Aprodu, Mihaela Moscalu and Simona Gavrilescu

ABSTRACT

Obiective. Identificarea corelaţiilor între evoluţia clinică a nou-născuţilor cu enterocolita ulceronecrotică (EUN) şi stadiul de boală, factorii de risc asociaţi, respectiv tipul de tratament utilizat.

Material şi metodă. S-a realizat un studiu retrospectiv pe o perioadă de 6 ani pe baza cazuisticii Centrului Regional de Terapie Intensivă Neonatală „Cuza Voda“ şi s-au identificat 205 cazuri de enterocolită ulceronecrotică dintr-un total de 6.183 de nou-născuţi îngrijiţi aici. Bolnavii au fost împărţiţi în loturi de studiu în funcţie de vârsta de gestaţie (VG), respectiv greutatea la naştere (GN). Protocolul de analiză s-a realizat pe baza unei fişe de lucru care a cuprins datele epidemiologice ale pacienţilor, factorii de risc, tipul alimentaţiei, vârstă în momentul diagnosticului, stadiul de boală conform clasificării Bell, modalitatea de tratament (medical, chirurgical sau mixt), complicaţiile înregistrate şi evoluţia pacienţilor. Prelucrarea statistică a datelor s-a făcut utilizând programul SPSS Statistics 20.

Rezultate. Enterocolita ulceronecrotică a avut o frecvenţă de 3,3% în lotul studiat şi a fost diagnosticată la nounăscuţii prematuri în 75,6% dintre cazuri. VG medie în grupul de studiu a fost de 33 săptămâni. GN medie a fost de 1.896 g, cu 43% dintre cazuri în grupul cu greutate foarte mică la naştere (VLBW) şi 31,2% în grupul cu greutate mică la naştere (LBW). Incidenţa procentuală a factorilor de risc a fost următoarea în ordinea frecvenţei: persistenţa canalului arterial 19,5%, asfixia perinatală 13,7%, detresa respiratorie 100% dintre cazuri. 75,5% dintre cazuri au fost tratate şi externate din CRTIN, 16,6% dintre cazuri au fost transferate în Clinica de Chirurgie Pediatrică a Spitalului „Sf. Maria“ şi 3,9% au decedat la CRTIN. Din cele 34 de cazuri transferate, 19 cazuri au fost tratate chirurgical: 8 cazuri cu drenaj peritoneal (DP), 8 cazuri cu laparotomie primara (LAP) şi 3 cazuri cu LAP şi DP. Rata supravieţuirii în acest grup a fost 2,4%, iar pentru grupul cu tratament medical a fost 4,9%.

Concluzii. Prematuritatea se corelează statistic cu stadii avansate de enterocolită în momentul diagnosticului. Modalitatea de tratament chirurgical aleasă (drenaj peritoneal sau laparotomie) nu influenţează rezultatele, iar alimentaţia enterală precoce cu formula de lapte este cel mai important factor de risc pentru apariţia EUN, urmat de vârsta de gestaţie şi greutatea foarte mică la naştere.

Cuvinte cheie: enterocolită ulceronecrotică, nou-născut, posibilităţi de tratament

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Elena Hanganu

NEONATAL NECROTIZING ENTEROCOLITIS: CLINICAL DATA AND TREATMENT POSSIBILITIES

SELECT ISSUE

Revista Romana de PEDIATRIE | Volumul LXIII, Nr. 4, An 2014
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

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Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
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Ebsco Host - Medline
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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

NEONATAL NECROTIZING ENTEROCOLITIS: CLINICAL DATA AND TREATMENT POSSIBILITIES

Elena Hanganu, Maria Stamatin, S.G. Aprodu, Mihaela Moscalu and Simona Gavrilescu

ABSTRACT

Objectives. The aim of this paper is to identify the correlations between the clinical evolution of the neonates with necrotizing enterocolitis (NEC) and the stage of disease, associated risk factors and the type of treatment used.

Material and methods. A 6 years retrospective study was performed based on reviewing the casuistry of the Regional Centre of Neonatal Intensive Care Unit (NICU) „Cuza Voda” and 205 cases of necrotizing enterocolitis were identified from a total number of 6183 neonates admitted there. Patients were divided in to study groups based on the gestational age (GA) and birth weight (BW). The analysis protocol was realized based on a working sheet that included the epidemiological data of the patients, the risk factors, type of nutrition, age at diagnosis, stage of disease according to Bell classification, type of treatment (medical, surgical or combined), complications and the general evolution. The statistical data processing was performed in SPSS Statistics 20 program.

Results. NEC had a frequency of 3.3% is the study group and was diagnosed in premature newborns in 75.6% of cases. The mean GA for the study group was 33 weeks. The mean BW was 1896 g with 43% of the cases in very low birth weight (VLBW) group and 31.2% in low birth weight (LBW) group. The percentage incidence of the risk factors was as follows: persistence of ductusarteriossus 19.5%, perinatal asphyxia 13.7% and respiratory distress 100% of cases. 75.5% were treated and discharged from NICU, 16.6% were transferred to Pediatric Surgery Department „Sf. Maria” and 3.9% died in NICU. From the 34 cases transferred19 cases were surgically treated: 8 cases with peritoneal drainage (PD), 8 cases with primary laparotomy (LAP) and 3 cases with PD and LAP. The survival rate in this group was 2.4% and for the medically treated group was 4.9%.

Conclusions. Prematurity is statistically correlated with encountering advanced stages of enterocolitis at the time of diagnosis. The option for surgical treatment (peritoneal drainage or laparotomy) does not influence the results and early enteral feeding with formula is the most important risk factor for NEC followed by age of gestation and very low birth weight.

Keywords: necrotizing enterocolitis, newborn, treatment possibilities

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Elena Hanganu


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