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Nicoleta Gimiga

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Articole semnate de acelasi autor in Revista Romana de Pediatrie:

DIAGNOSTIC SI TRATAMENT IN BOALA DE REFLUX GASTROESOFAGIAN – POSIBILITATI SI LIMITE

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Revista Romana de PEDIATRIE | Volumul LXV, Nr. 3, An 2016
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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DIAGNOSTIC SI TRATAMENT IN BOALA DE REFLUX GASTROESOFAGIAN – POSIBILITATI SI LIMITE

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REZUMAT

Departajarea refluxului gastro-esofagian (RGE) fiziologic (cel mai frecvent) de boala de reflux gastro-esofagian (BRGE) în primul an de viaţă este obligatorie pentru a evita farmacoterapia agresivă. La toate vârstele
copilăriei se aplică criterii moderne de evaluare clinică, sumând simptome digestive şi/sau extradigestive şi rezultatele unor investigaţii moderne. Tratamentul igieno-dietetic (suficient in RGE fiziologic), obligatoriu în toate cazurile, şi inhibitorii de pompă protonică dupa vârsta de un an induc remisiune în majoritatea cazurilor de RGE. Evoluţia cronică/recidivantă şi rezistenţa la tratamentul comun impun intervenţia chirurgicală, domeniu îmbogaţit recent la copil cu miotomia perorală endoscopică (POEM).

Cuvinte cheie: boală de reflux gastroesofagian, inhibitori de pompă de protoni, miotomia perorală endoscopică

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DIAGNOSIS AND TREATMENT IN GASTROESOPHAGEAL REFLUX DISEASE – POSSIBILITIES AND LIMITATIONS

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Revista Romana de PEDIATRIE | Volumul LXV, Nr. 3, An 2016
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

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DIAGNOSIS AND TREATMENT IN GASTROESOPHAGEAL REFLUX DISEASE – POSSIBILITIES AND LIMITATIONS

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ABSTRACT

In children’s first year of life it is mandatory to make a difference between physiological gastroesophageal reflux (GER) and gastroesophageal reflux disease (GERD), in order to avoid an aggressive pharmacologic therapy. All ages of childhood benefit from modern criteria of clinical evaluation, by corroborating the digestive or extradigestive symptoms with the results of modern investigations. The dietary measures (sufficient in GER but mandatory in all cases) together with proton pump inhibitors administration after one year of age induce remission in majority of GER cases. The chronic and recurrent evolution of the disease or failure of the common treatment require surgical intervention, recently enriched in children with peroral endoscopic myotomy (POEM).

Keywords: gastroesophageal reflux disease, proton pump inhibitors, Peroral Endoscopic Myotomy

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RECOMANDARI PRE-PROCEDURALE IN ENDOSCOPIA DIGESTIVA LA PACIENTUL PEDIATRIC

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Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 4, An 2015
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

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Promoting Global Health

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RECOMANDARI PRE-PROCEDURALE IN ENDOSCOPIA DIGESTIVA LA PACIENTUL PEDIATRIC

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REZUMAT

Endoscopia digestivă, una dintre cele mai frecvente investigaţii invazive în gastroenterologia pediatrică, nu este lipsită de riscuri. Complexul de măsuri necesare acestei manevre cuprinde: evaluarea corectă a bolnavului ţinând seama de indicaţiile şi contraindicaţiile endoscopiei, obţinerea consimţământului informat, pregătirea psihologică a părinţilor/copilului, aplicarea unor restricţii dietetice, profilaxia infecţiilor. De asemenea, trebuie ales tipul de anestezie, monitorizarea continuă intra şi post-procedurală pentru evitarea complicaţiilor legate de procedură sau de reacţii adverse medicamentoase.

Cuvinte cheie: anestezie, endoscopie digestivă, copil

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PRE-PROCEDURAL RECOMMENDATIONS IN PEDIATRIC GASTROINTESTINAL ENDOSCOPY

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Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 4, An 2015
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

PRE-PROCEDURAL RECOMMENDATIONS IN PEDIATRIC GASTROINTESTINAL ENDOSCOPY

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ABSTRACT

Gastrointestinal endoscopy is one of the most common invasive procedures carried out in pediatric gastroenterology and is not without risk. The range of necessary measures for the purpose of this procedure includes: the accurate assessment of the patient considering the endoscopy-related indications and contraindications, obtaining the informed consent, the psychological preparation of the parents/child, applying some dietary restrictions, and infection prophylaxis. It is also necessary to choose the type of sedation and ensure the constant monitoring during and after the procedure so as to avoid any complications related to the procedure or to the side effects of drugs.

Keywords: procedural sedation, gastrointestinal endoscopy, child

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GASTRITELE SI HELICOBACTER PYLORI LA COPIL – DIAGNOSTICUL ENDOSCOPIC PRIMAR SI SECUNDAR

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Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 3, An 2015
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

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GASTRITELE SI HELICOBACTER PYLORI LA COPIL – DIAGNOSTICUL ENDOSCOPIC PRIMAR SI SECUNDAR

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REZUMAT

Infecţia cu Helicobacter pylori (H. pylori) este o problemă comună şi semnificativă de sănătate publică.
Obiectiv. Determinarea prevalenţei infecţiei cu H. pylori la copiii cu simptomatologie sugestivă şi conturarea cazurilor în funcţie de tipul şi felul gastritei prin efectuarea de endoscopii digestive superioare.
Material şi metodă. Studiu retrospectiv realizat pe o perioadă de 5 ani pe 1.269 de copii cu simptomatologie gastrică, la care s-au efectuat endoscopii cu biopsie, stabilindu-se rata de infecţie cu H. pylori prin examen direct sau testul ureazei.
Rezultate. Frecvenţa H. pylori în cazul gastritei acute a fost semnificativ mai mică (34,78%) comparativ cu frecvenţa acesteia în cazul gastritei cronice (54,94%). În cadrul celor 10 tipuri de gastrită, cele mai frecvente sunt formele purpurice (43,66%), nodular purpurică (25,93%) şi nodular antrală (15,84%), la polul opus situându-se gastrita atrofică şi hipertrofică. Asocierile cele mai frecvente decelate endoscopic sunt cu esofagita gr I în 51,6%, duodenita în 45,07% şi forma purpurică în 24,74%.
Concluzii. Infecţia cu H. pylori este cel mai frecvent asociată gastritei cronice (54,94%). Identificarea precoce a infecţiei este esenţială pentru eradicarea bacteriei şi prevenirea apariţiei diferitelor tipuri de gastrită identificate endoscopic.

Cuvinte cheie: gastrită, H. pylori, endoscopie, copil

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GASTRITIS AND HELICOBACTER PYLORI IN CHILDREN – PRIMARY AND SECONDARY ENDOSCOPIC DIAGNOSIS

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Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 3, An 2015
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

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GASTRITIS AND HELICOBACTER PYLORI IN CHILDREN – PRIMARY AND SECONDARY ENDOSCOPIC DIAGNOSIS

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ABSTRACT

The infection with Helicobacter pylori (H pylori) represents an important issue of public health.
Aim. Establishing the prevalence of H. pylori infection in children and presenting the cases according to the gastritis type by performing upper digestive endoscopies.
Material and method. The retrospective study referred to a period of 5 years and included 1269 children evaluated by upper endoscopy to establish the H. pylori infection rate.
Results. The frequency of H. pylori in the case of acute gastritis was significantly more reduced (34.78%) than in the case of chronic gastritis (54.94%). Referring to the 10 types of gastritis, the most frequent ones are purpuric (43.66%), nodular purpuric (25.93%) and nodular antral (15.84%). At the other end, atrophic and hypertrophic gastritis were positioned. The most frequent associations pointed out endoscopically are those with 1st degree esophagitis - 51.6%, duodenitis – 45.07% and purpuric duodenitis – 24.74%.
Conclusions. The H. pylori infection is the most frequent etiologic factor for chronic gastritis (54.94%). The early identification of the infection is essential to destroy the bacteria and to prevent the development of various types of gastritis that are later on endoscopically identified.

Keywords: gastritis, H. pylori, upper endoscopy, child

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Eradication of Helicobacter Pylori infection in children: current matters and perspectives

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Revista Romana de PEDIATRIE | Volumul LX, Nr. 2, An 2011
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

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Eradication of Helicobacter Pylori infection in children: current matters and perspectives

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ABSTRACT

The strategies used to treat Helicobacter pylori infection in children derives mostly from recommendations based on clear consents in adult patients. The triple therapy that associates proton pump inhibitors (PPI), clarithromycin and amoxicillin is used on a large extent all over the world; beside this, other associations came out based either on PPI or bismuth salts. Nowadays, new drugs were introduced in anti-bacterial schemes, alongside esomeprazole, pantoprazole or lansoprazole being azithromicine and fluoroquinolones (in older children). At the same time, second line therapies were suggested in order to treat relapse or bacterial reinfection and these are quadruple associations based on bismuth salts or regimens including fluoroquinolones; the introduction of sequential therapy in children also represents a promising alternative. Concerning prophylaxy, the oral or intramuscular vaccine (the latter being in an advance clinical trial), should be able to contribute in the future to decrease the incidence of H.pylori infection, gastritis, ulcer and gastric cancer.

Key words: H.pylori, quadruple schemes, fluoroquinolones, sequential therapy, vaccine

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ERADICAREA INFECTIEI CU HELICOBACTER PYLORI LA COPIL: ACTUALITATI SI PERSPECTIVE

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Revista Romana de PEDIATRIE | Volumul LX, Nr. 2, An 2011
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

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ERADICAREA INFECTIEI CU HELICOBACTER PYLORI LA COPIL: ACTUALITATI SI PERSPECTIVE

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REZUMAT

Strategiile utilizate în tratamentul infecţiei cu Helicobacter pylori la copii derivă în mare parte din schemele de tratament stabilite de consensuri clare la pacienţii adulţi. Tripla terapie ce asociază inhibitori de pompă protonică (IPP), claritromicina şi amoxicilina este utilizată pe scară largă în întreaga lume; alături de aceasta s-au impus şi alte asocieri bazate fie pe IPP, fie pe săruri de bismut. La ora actuală au fost introduse noi preparate în schemele antibacteriene, alături de esomeprazol, pantoprazol sau lansoprazol aflându-se azitromicina şi fluorochinolonele (la copiii mari). În acelasi timp au fost propuse terapii de linia a doua, rezervate cazurilor de recădere sau reinfecţie bacteriană, acestea fiind reprezentate de asocieri cvadruple bazate pe săruri de bismut sau de regimuri ce includ fluorochinolone; nu în ultimul rând, introducerea terapiei secvenţiale la copii reprezintă o alternativă promiţătoare. Pe plan profilactic, vaccinarea orală sau intramusculară, aceasta din urmă aflată în faze avansate de testare clinică, va putea contribui în viitor la scăderea incidenţei infecţiei cu H.pylori, a gastritei, ulcerului şi cancerului gastric.

Cuvinte cheie: H.pylori, scheme cvadruple, fluorochinolone, terapie secvenţială, vaccin

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Chronical constipation multifactorial etiopathogeny in childhood

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Revista Romana de PEDIATRIE | Volumul LXII, Nr. 2, An 2013
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

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Chronical constipation multifactorial etiopathogeny in childhood

, , , , and

ABSTRACT

Constipation is an apparently common condition in children, but it has important consequences in pediatric age. Its prevalence varies between 0.7 and 29.6% (with an average of 8%), with no important difference between sexes. The etiology still remains unclear, and although many mechanisms involved in this disease were discovered, it is still very heterogenous. Constipation may be functional, related with an inadequate diet or with psychical circumstances which influences the normal act of defecation, organic, in which gastrointestinal diseases and not only, play a big role, or it may be talked about a genetic determinism. Specific associated gene mutations haven’t been related yet. There are plenty of genetic syndromes in which constipation is a frequent symptom. Trying to objectify the diagnosis, many types of classifications were suggested, based on the main types of the symptoms. Despite of this, diagnosing constipation in children still remains an important challenge.

Key words: child, constipation, delayed bowel movements

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ETIOPATOGENIA MULTIFACTORIALA A CONSTIPATIEI CRONICE LA VARSTA PEDIATRICA

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Revista Romana de PEDIATRIE | Volumul LXII, Nr. 2, An 2013
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

ETIOPATOGENIA MULTIFACTORIALA A CONSTIPATIEI CRONICE LA VARSTA PEDIATRICA

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REZUMAT

Constipaţia este o patologie aparent banală, dar cu implicaţii importante la vârsta pediatrică. Prevalenţa acesteia variază de la 0,7% la 29,6% (în medie 8%), fără o diferenţă semnificativă între sexe. Etiologia constipaţiei rămâne încă neclară, fiind extrem de heterogenă în ciuda identificării a numeroase mecanisme ce stau la baza acestei afecţiuni. Constipaţia poate fi de natură funcţională, corelată cu o dietă neadecvată sau cu circumstante de natură psihică ce influenţează desfăşurarea normală a defecaţiei, organică, având la bază diferite boli ale tractului gastrointestinal şi nu numai, sau poate avea determinism genetic. Cu toate acestea, încă nu s-au găsit mutaţii genice asociate în mod specific. Numeroase sindroame genetice asociază ca mainifestare clinică constipaţia. În încercarea concretizării diagnosticului au fost propuse diferite clasificări bazate pe simptomatologie. Cu toate acestea, diagnosticul constipaţiei la populaţia pediatrică poate fi dificil de stabilit.

Cuvinte cheie: copil, constipaţie, tranzit intestinal încetinit

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