Maria Despina Baghiu

Latest posts by Maria Despina Baghiu (see all)

TIMOMUL: O CAUZA RARA DE TUMORA MEDIASTINALA LA COPIL - 22/02/2017
THYMOMA: A RARE CAUSE OF MEDIASTINAL TUMOR IN CHILDREN - 22/02/2017
EVALUAREA TROMBOCITOZEI REACTIVE POSTSPLENECTOMIE LA PACIENTUL PEDIATRIC - 30/08/2016

Articole semnate de acelasi autor in Revista Romana de Pediatrie:

TIMOMUL: O CAUZA RARA DE TUMORA MEDIASTINALA LA COPIL

Revista Romana de PEDIATRIE | Volumul LXV, Nr. 4, An 2016

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

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Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Andreea Durlan, Cristina Oana Mărginean, Maria Despina Baghiu, Alina Grama, Emoke Horvath and Mihaela-Ioana Chincesan

REZUMAT

Timomul este un neoplasm format din celule epiteliale timice, fiind rar întâlnit la copii. Aproximativ două treimi din tumorile mediastinale sunt asimptomatice la copii, diagnosticul fiind suspicionat în urma efectului de compresie a masei tumorale asupra căilor respiratorii. Prezentăm cazul unui pacient de sex masculin, în vârstă de 7 ani şi 8 luni, care se prezintă în serviciul de urgenţă acuzând oboseală la eforturi mici/repaus, tuse seacă, dispnee marcată, ortopnee, tahipnee, durere toracică, de unde se transferă de urgenţă la Clinica de Cardiologie Pediatrică, Tîrgu Mureş, cu diagnosticele: pericardită lichidiană, tamponadă cardiacă şi pleurezie dreaptă. Examenul computer tomografic toracic descrie o masă solidă inomogenă de 100/89/111 mm, la nivelul mediastinului anterior înglobând timusul şi parţial structurile vasculare ale mediastinului mijlociu. Se practică pericardectomie parţială, prelevare de ţesut tumoral şi citoreducţie tumorală extensivă, examenul histopatologic fiind Timom B3. Se iniţiază chimioterapie conform protocolului VENUTA Tymom, urmat de radioterapie adjuvantă, cu remisie clinică şi radiologică. Particularitatea cazului este dată de faptul că timomul este o tumoră rară la vârsta pacientului, creând dificultăţi de diagnostic, fiind fără complicaţii în timpul tratamentului, cu evoluţie favorabilă, cu remisie clinică şi radiologică la 1,9 ani.

Cuvinte cheie: copil, timom, tumoră mediastinală

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Andreea Durlan

THYMOMA: A RARE CAUSE OF MEDIASTINAL TUMOR IN CHILDREN

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Andreea Durlan, Cristina Oana Mărginean, Maria Despina Baghiu, Alina Grama, Emoke Horvath and Mihaela-Ioana Chincesan

ABSTRACT

Thymoma is a thymic neoplasm composed of epithelial cells, rarely seen in children. Approximately two-thirds of mediastinal tumors in children are asymptomatic. The diagnosis is suspected following the compression of the tumor mass on the airways. We present the case of a male patient, age 7 years and 8 months, who presented at the emergency room accusing fatigue at rest or minimum effort, dry cough, intense dyspnea, orthopnea, tachypnea, chest pain, being transferred to the Pediatric Cardiology Clinic in Tirgu Mures with the following diagnoses: fluid pericarditis, right pleural effusion and cardiac tamponade. Chest computer tomography examination is carried out, describing a solid mass of 100/89/111 mm in the anterior mediastinum, partially incorporating the thymus and the vascular structures of the middle mediastinum. Pericardectomy is practiced with partial removal of the tumor and extensive tumor cytoreduction and the histopathologic examination is B3 Thymoma. Specific treatment is initiated according to the Tymoma VENUTA protocol, followed by adjuvant radiotherapy, with clinical and radiological remission. The particularity of the case is the fact that thymoma is a rare tumor on the patient’s age, creating diagnostic difficulties, has no complications during treatment, with favorable evolution, with clinical and radiological remission at 1.9 years after.

Keywords: child, thymoma, mediastinal tumor

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Andreea Durlan

EVALUAREA TROMBOCITOZEI REACTIVE POSTSPLENECTOMIE LA PACIENTUL PEDIATRIC

Revista Romana de PEDIATRIE | Volumul LXV, Nr. 2, An 2016

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Alina Grama, Andreea Durlan, Andreea Ligia Dinca, Cristina Oana Mărginean, Horea Gozar, Maria Despina Baghiu, Mihaela Chincesan, Mihai Stanca and Raluca Damian

REZUMAT

Trombocitoza reprezintă creşterea numărului de trombocite peste 500.000/mm³.
Obiectiv. Obiectivul acestui studiu este de a evalua frecvenţa şi severitatea trombocitozei reactive la pacienţii pediatrici splenectomizaţi.
Material şi metodă. Am realizat un studiu retrospectiv în care au fost incluşi 20 de pacienţi (4-16 ani) care au suferit o intervenţie de splenectomie în intervalul 2006-2015. Criteriile de includere în studiu au fost: pacienţi cu vârsta sub 18 ani, care au fost splenectomizaţi şi care au dezvoltat trombocitoză ulterior intervenţiei.
Rezultate. În lotul studiat, 80% dintre pacienţii splenectomizaţi (16) au dezvoltat o formă de trombocitoză; în 4 cazuri formă severă (trombocite > 1milion/mm3), iar în 7 cazuri formă uşoară. Nu s-au observat diferenţe semnificative în repartiţia pe sexe a pacienţilor (9 de sex feminin şi 11 de sex masculin). La 13 dintre pacienţi trombocitoza s-a remis după 30 de zile şi doar în 3 dintre cazuri episodul a durat >360 de zile. Fenomene trombotice s-au observat la un singur pacient din lotul studiat. Toţi pacienţii au beneficiat de măsuri de tromboprofilaxie şi hidratare, iar 2 cazuri au necesitat asociere terapeutică de Hidoxiuree.
Concluzii. Studiul nostru relevă o frecvenţă crescută a trombocitozei după splenectomie (80%), cu un vârf maxim de incidenţă la 2-10 zile postchirurgical, trombocitoza fiind în general benignă şi cu remisie spontană; evenimente trombotice s-au semnalat într-un singur caz, iar trombocitoza severă a fost mai frecventă după splenectomia de cauză traumatică.

Cuvinte cheie: trombocitoză, splenectomie, copil

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Alina Grama

TROMBOCYTOSIS FOLLOWING SPLENECTOMY IN PEDIATRIC PATIENTS

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Alina Grama, Andreea Durlan, Andreea Ligia Dinca, Cristina Oana Mărginean, Horea Gozar, Maria Despina Baghiu, Mihaela Chincesan, Mihai Stanca and Raluca Damian

ABSTRACT

Thrombocytosis represents a platelet count over 500.000/mm³.
Objective. The aim of this study is to evaluate the frequency and gravity of reactive thrombocytosis in pediatric patients who underwent splenectomy.
Material and method. We performed a retrospective study including 20 patients (4-16 years old) who underwent splenectomy between 2006-2015. The inclusion criteria in the study were: patients with the age under 18 years, who underwent splenectomy independently by the cause, and who developed afterwards thrombocytosis.
Results. In the studied group 64% of the splenectomised patients (16) developed a form of thrombocytosis. In 4 cases – severe form (Platelets > 1 million/mm3) and in 7 cases a mild form. There were not noticed any significant differences regarding the gender repartition of the patients (9 were females, and 11 were males). In 13 patients, thrombocytosis disappeared after 30 days, and only in 3 cases, the episode lasted more than 360 days. Thrombotic phenomena were noticed only in one patient from our study group. All the patients benefited from thromboprophylaxis and hydration measures, and 2 cases needed associated treatment with Hydroxyurea.
Conclusions. Our study reveals an increased frequency of thrombocytosis after splenectomy (80%), with a maximum peak of incidence in 2-10 days following the intervention, thrombocytosis being generally benign and self-limited; still one of the cases experienced thrombotic complications and severe thrombocytosis was more frequent after post-traumatic splenectomy.

Keywords: thrombocytosis, splenectomy, child

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Alina Grama

Recent acquisitions in imaging diagnosis of digestive disorders in children

Revista Romana de PEDIATRIE | Volumul LXI, Nr. 1, An 2012

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Cristina Oana Mărginean, Ana Maria Pitea, Maria Despina Baghiu, Klara Brinzaniuc and Claudiu Mărginean

REZUMAT

Elastography is a new imaging method based on ultrasounds, which allows the assessment of the tissues structure in terms of their stiffness, being useful in the exploration of different organs and systems, having more and more clinical applications. The development of the contrast agents of second generation led to the amplification of the ultrasound signals using the microbubbles, which can not cross the vascular wall and are eliminated through exhalation within 15 minutes.

Material and methods. We present the results of a prospective study conducted in our Clinic, assessing the performance of the ARFI method (”Acustic Radiation Force Imaging”) in the assessment of the liver elasticity in children and we present some pediatric cases in which the ultrasound with contrast has brought real benefits, making it easier to diagnose and facilitate optimal therapeutic decisions.

Key words: imagistic diagnosis, elastography, contrast, digestive, child

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Cristina Oana Mărginean

ACHIZITII RECENTE IN DIAGNOSTICUL IMAGISTIC AL BOLILOR DIGESTIVE LA COPIL

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Cristina Oana Mărginean, Ana Maria Pitea, Maria Despina Baghiu, Klara Brinzaniuc and Claudiu Mărginean

REZUMAT

Elastografia este o nouă metodă imagistică bazată pe ultrasunete, care permite evaluarea structurii ţesuturilor în ceea ce priveşte rigiditatea lor, fiind utilă în explorarea diferitelor organe şi sisteme şi cu tot mai multe aplicaţii clinice. Dezvoltarea substanţelor de contrast de generaţia a doua a dus la amplificarea semnalului ecografic cu ajutorul microbulelor, care nu pot străbate peretele vascular şi care se elimină prin exhalare în 15 minute.

Material şi metode. Prezentăm rezultatele unui studiu prospectiv derulat în clinica noastră, evaluând performanţele metodei ARFI (impulsul de difuzie a forţei acustice) în evaluarea elasticităţii ficatului la copii; prezentăm şi câteva cazuri pediatrice în care ecografia cu contrast a adus reale beneficii, uşurând diagnosticul şi facilitând luarea deciziilor terapeutice optime.

Cuvinte cheie: diagnostic imagistic, elastografie, contrast, digestiv, copil

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Cristina Oana Mărginean

Body composition of children with malignant disease

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Mihaela Ioana Chinceşan, Maria Despina Baghiu, Alina Grama and Oana Marginean

ABSTRACT

Background. Nutritional status, as represented by body composition, is an important considerant in the treatment of pediatric cancer patients because it is linked to poor outcomes.

Objective. We aimed to compare nutritional status with children with malignant disease at diagnosis as compared to children with nononcological disease.

Material and method: A prospective study was performed on 90 children hospitalised in the Pediatric Clinic I Tg. Mures, between November 2009 - July 2011. The children were divided into two groups: group 1, children with malignant disease (35 children) and group 2-control group, children with different pediatric diseases (55 children). We have done anthropometric and biochemical measuremeants: weight, height, body mass index, middle upper arm circumference, tricipital skin fold thickness, total serum protein and albumin, Insulin-like growth factor-1, total cholesterol, tryglicerides and sideremy. We studied the anthropometric and biochemical parameters compared to the two groups and performed statistical correlations.

Results. The weight and height of children in group I was much lower compared with group II, without statistically significant difference (p>0.05). We also found a statistically significant difference among the anthropometric parameters of the arm: middle upper arm circumference – MUAC (-1.58 DS versus -0.74 DS ) with p = 0.022 and tricipital skin fold thickness – TSF (-1.34 DS versus -0.74 DS) with p = 0.05. Regarding biochemical parameters, between the two groups, we observed a significant difference(p<0.05) with the total serum protein and albumin, IGF-1, sideremy and tryglicerides.

Conclusions. This study showed that the children’s group diagnosed with cancer has a poor nutritional status than the control group; the anthropometric parameters of the arm in conjunction with biochemical parameters best reflects the body composition.

Key words: child, malignant disease, anthropometric parameters, biochemical parameters

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Mihaela Ioana Chinceşan

COMPOZITIA CORPORALA LA COPIII CU BOALA MALIGNA

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Mihaela Ioana Chinceşan, Maria Despina Baghiu, Alina Grama and Oana Marginean

REZUMAT

Introducere. Statusul nutriţional, reprezentat de compoziţia corpului, este un considerent important în tratamentul pacienţilor pediatrici oncologici deoarece influenţează evoluţia bolii. Obiectiv. Ne-am propus să evaluăm comparativ statusul de nutriţie la copiii cu boală malignă la momentul diagnosticării bolii faţă de copiii cu afecţiuni nononcologice.

Material şi metodă. Am efectuat un studiu prospectiv pe un număr de 90 de copii internaţi în Clinica Pediatrie I Tg- Mureş în perioada noiembrie 2009 – iulie 2011. Copiii au fost împărţiţi în două loturi: lotul I, reprezentat de copii cu boală malignă (35 copii) şi lotul II – martor, reprezentat de copii cu diverse afecţiuni pediatrice (55 copii). Am efectuat măsurători antropometrice şi biochimice: greutatea, înălţimea, indicele de masă corporală, perimetrul mediu al braţului, pliul cutanat tricipital, proteine totale şi albumine serice, IGF-1, colesterol total, trigliceride şi sideremie. Am urmărit comparativ parametrii antropometrici şi biochimici la cele două loturi şi am efectuat corelaţii statistice.

Rezultate. Greutatea şi înălţimea copiilor din lotul I a fost mai mică faţă de lotul II, fără o diferenţă semnificativă statistic (p>0,05). Am constatat o diferenţă semnificativă statistic în rândul parametrilor antropometrici ai braţelor: perimetrul mediu al braţului – MUAC (-1,58 DS la lotul I şi -0,74DS la lotul II) cu p=0,022 şi pliul cutanat tricipital –TSF (-1,34 DS la lotul I şi -0,76 DS la lotul II) cu p=0,05. Urmărind parametrii biochimici, am observat o diferenţă semnificativă statistic (p<0,05) între cele două loturi în ceea ce priveşte valoarea proteinelor totale, albuminele serice şi IGF-1, sideremia şi trigliceridele.

Concluzii. Studiul demonstrează că pacienţii diagnosticaţi cu cancer prezintă status nutriţional precar faţă de pacienţii nononcologici; parametrii antropometrici ai braţelor, coroboraţi cu parametrii biochimici reflectă cel mai bine compoziţia corporală.

Cuvinte cheie: copil, boală malignă, parametru antropometric, parametru biochimic

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Mihaela Ioana Chinceşan

A case of Stevens Johnson syndrome in child

Revista Romana de PEDIATRIE | Volumul LXI, Nr. 2, An 2012

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Cristina Oana Mărginean, Maria Despina Baghiu, Carmen Duicu, Ana Maria Pitea and Claudiu Mărginean

ABSTRACT

We present a 9-year-old boy with epilepsy refractory to previous treatment diagnosed with Stevens Johnson syndrome appeared after the introduction of Lamictal in treatment. The boy had fever, polymorphous exanthema, papulopustular erythematous, bullous generalized vesiculobullous elements and skin denudation, conjunctivitis, mouth lesions. We have interpreted the associated pneumonia as a damage of a lower respiratory tract mucous membranes within Stevens Johnson syndrome. The evolution of the disease was favourable after high doses of Ig IV (intravenous immunoglobulin). In conclusion, even if the Steven Johnson syndrome incidence is low in children, pediatricians should be aware of the possibility of its reggresion (even after antiepileptics - Lamictal), and even if the use of Ig IV is controversial, it leads to healing when is given in high doses.

Key words: Stevens Johnson syndrome, child, epilepsy, Lamotrigine (Lamictal)

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Cristina Oana Mărginean

UN CAZ DE SINDROM STEVENS JOHNSON LA COPIL

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Cristina Oana Mărginean, Maria Despina Baghiu, Carmen Duicu, Ana Maria Pitea and Claudiu Mărginean

REZUMAT

Prezentăm cazul unui băiat de 9 ani cu epilepsie refractară la tratamentul anterior, diagnosticat cu sindrom Stevens Johnson apărut după introducerea în tratament a Lamictalului. Băiatul a prezentat febră, exantem polimorf maculo-papulo-eritematos, cu elemente veziculo buloase generalizate şi denudare tegumentară, conjunctivită, leziuni bucale. Pneumonia asociata am interpretat-o ca afectare a mucoasei tractului respirator inferior din cadrul sindromului Stevens Johnson. Evoluţia bolii a fost favorabilă după doze mari de imunoglobuline intravenos. În concluzie, deşi incidenţa sindromului Steven Johnson este mică la copil, pediatrii trebuie să fie conştienţi de posibilitatea apariţiei ei (chiar după antiepileptice – Lamictal), iar utilizarea imunoglobulinelor IV, deşi controversată, administrată în doze mari pare că duce la vindecarea bolii.

Cuvinte cheie: Sindrom Stevens Johnson, copil, epilepsie, Lamotrigin (Lamictal)

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Cristina Oana Mărginean

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