Andreea Durlan

Latest posts by Andreea Durlan (see all)

TIMOMUL: O CAUZA RARA DE TUMORA MEDIASTINALA LA COPIL - 22/02/2017
THYMOMA: A RARE CAUSE OF MEDIASTINAL TUMOR IN CHILDREN - 22/02/2017
EVALUAREA TROMBOCITOZEI REACTIVE POSTSPLENECTOMIE LA PACIENTUL PEDIATRIC - 30/08/2016

Articole semnate de acelasi autor in Revista Romana de Pediatrie:

TIMOMUL: O CAUZA RARA DE TUMORA MEDIASTINALA LA COPIL

Revista Romana de PEDIATRIE | Volumul LXV, Nr. 4, An 2016

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Andreea Durlan, Cristina Oana Mărginean, Maria Despina Baghiu, Alina Grama, Emoke Horvath and Mihaela-Ioana Chincesan

REZUMAT

Timomul este un neoplasm format din celule epiteliale timice, fiind rar întâlnit la copii. Aproximativ două treimi din tumorile mediastinale sunt asimptomatice la copii, diagnosticul fiind suspicionat în urma efectului de compresie a masei tumorale asupra căilor respiratorii. Prezentăm cazul unui pacient de sex masculin, în vârstă de 7 ani şi 8 luni, care se prezintă în serviciul de urgenţă acuzând oboseală la eforturi mici/repaus, tuse seacă, dispnee marcată, ortopnee, tahipnee, durere toracică, de unde se transferă de urgenţă la Clinica de Cardiologie Pediatrică, Tîrgu Mureş, cu diagnosticele: pericardită lichidiană, tamponadă cardiacă şi pleurezie dreaptă. Examenul computer tomografic toracic descrie o masă solidă inomogenă de 100/89/111 mm, la nivelul mediastinului anterior înglobând timusul şi parţial structurile vasculare ale mediastinului mijlociu. Se practică pericardectomie parţială, prelevare de ţesut tumoral şi citoreducţie tumorală extensivă, examenul histopatologic fiind Timom B3. Se iniţiază chimioterapie conform protocolului VENUTA Tymom, urmat de radioterapie adjuvantă, cu remisie clinică şi radiologică. Particularitatea cazului este dată de faptul că timomul este o tumoră rară la vârsta pacientului, creând dificultăţi de diagnostic, fiind fără complicaţii în timpul tratamentului, cu evoluţie favorabilă, cu remisie clinică şi radiologică la 1,9 ani.

Cuvinte cheie: copil, timom, tumoră mediastinală

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Andreea Durlan

THYMOMA: A RARE CAUSE OF MEDIASTINAL TUMOR IN CHILDREN

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Andreea Durlan, Cristina Oana Mărginean, Maria Despina Baghiu, Alina Grama, Emoke Horvath and Mihaela-Ioana Chincesan

ABSTRACT

Thymoma is a thymic neoplasm composed of epithelial cells, rarely seen in children. Approximately two-thirds of mediastinal tumors in children are asymptomatic. The diagnosis is suspected following the compression of the tumor mass on the airways. We present the case of a male patient, age 7 years and 8 months, who presented at the emergency room accusing fatigue at rest or minimum effort, dry cough, intense dyspnea, orthopnea, tachypnea, chest pain, being transferred to the Pediatric Cardiology Clinic in Tirgu Mures with the following diagnoses: fluid pericarditis, right pleural effusion and cardiac tamponade. Chest computer tomography examination is carried out, describing a solid mass of 100/89/111 mm in the anterior mediastinum, partially incorporating the thymus and the vascular structures of the middle mediastinum. Pericardectomy is practiced with partial removal of the tumor and extensive tumor cytoreduction and the histopathologic examination is B3 Thymoma. Specific treatment is initiated according to the Tymoma VENUTA protocol, followed by adjuvant radiotherapy, with clinical and radiological remission. The particularity of the case is the fact that thymoma is a rare tumor on the patient’s age, creating diagnostic difficulties, has no complications during treatment, with favorable evolution, with clinical and radiological remission at 1.9 years after.

Keywords: child, thymoma, mediastinal tumor

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Andreea Durlan

EVALUAREA TROMBOCITOZEI REACTIVE POSTSPLENECTOMIE LA PACIENTUL PEDIATRIC

Revista Romana de PEDIATRIE | Volumul LXV, Nr. 2, An 2016

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Alina Grama, Andreea Durlan, Andreea Ligia Dinca, Cristina Oana Mărginean, Horea Gozar, Maria Despina Baghiu, Mihaela Chincesan, Mihai Stanca and Raluca Damian

REZUMAT

Trombocitoza reprezintă creşterea numărului de trombocite peste 500.000/mm³.
Obiectiv. Obiectivul acestui studiu este de a evalua frecvenţa şi severitatea trombocitozei reactive la pacienţii pediatrici splenectomizaţi.
Material şi metodă. Am realizat un studiu retrospectiv în care au fost incluşi 20 de pacienţi (4-16 ani) care au suferit o intervenţie de splenectomie în intervalul 2006-2015. Criteriile de includere în studiu au fost: pacienţi cu vârsta sub 18 ani, care au fost splenectomizaţi şi care au dezvoltat trombocitoză ulterior intervenţiei.
Rezultate. În lotul studiat, 80% dintre pacienţii splenectomizaţi (16) au dezvoltat o formă de trombocitoză; în 4 cazuri formă severă (trombocite > 1milion/mm3), iar în 7 cazuri formă uşoară. Nu s-au observat diferenţe semnificative în repartiţia pe sexe a pacienţilor (9 de sex feminin şi 11 de sex masculin). La 13 dintre pacienţi trombocitoza s-a remis după 30 de zile şi doar în 3 dintre cazuri episodul a durat >360 de zile. Fenomene trombotice s-au observat la un singur pacient din lotul studiat. Toţi pacienţii au beneficiat de măsuri de tromboprofilaxie şi hidratare, iar 2 cazuri au necesitat asociere terapeutică de Hidoxiuree.
Concluzii. Studiul nostru relevă o frecvenţă crescută a trombocitozei după splenectomie (80%), cu un vârf maxim de incidenţă la 2-10 zile postchirurgical, trombocitoza fiind în general benignă şi cu remisie spontană; evenimente trombotice s-au semnalat într-un singur caz, iar trombocitoza severă a fost mai frecventă după splenectomia de cauză traumatică.

Cuvinte cheie: trombocitoză, splenectomie, copil

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Alina Grama

TROMBOCYTOSIS FOLLOWING SPLENECTOMY IN PEDIATRIC PATIENTS

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Alina Grama, Andreea Durlan, Andreea Ligia Dinca, Cristina Oana Mărginean, Horea Gozar, Maria Despina Baghiu, Mihaela Chincesan, Mihai Stanca and Raluca Damian

ABSTRACT

Thrombocytosis represents a platelet count over 500.000/mm³.
Objective. The aim of this study is to evaluate the frequency and gravity of reactive thrombocytosis in pediatric patients who underwent splenectomy.
Material and method. We performed a retrospective study including 20 patients (4-16 years old) who underwent splenectomy between 2006-2015. The inclusion criteria in the study were: patients with the age under 18 years, who underwent splenectomy independently by the cause, and who developed afterwards thrombocytosis.
Results. In the studied group 64% of the splenectomised patients (16) developed a form of thrombocytosis. In 4 cases – severe form (Platelets > 1 million/mm3) and in 7 cases a mild form. There were not noticed any significant differences regarding the gender repartition of the patients (9 were females, and 11 were males). In 13 patients, thrombocytosis disappeared after 30 days, and only in 3 cases, the episode lasted more than 360 days. Thrombotic phenomena were noticed only in one patient from our study group. All the patients benefited from thromboprophylaxis and hydration measures, and 2 cases needed associated treatment with Hydroxyurea.
Conclusions. Our study reveals an increased frequency of thrombocytosis after splenectomy (80%), with a maximum peak of incidence in 2-10 days following the intervention, thrombocytosis being generally benign and self-limited; still one of the cases experienced thrombotic complications and severe thrombocytosis was more frequent after post-traumatic splenectomy.

Keywords: thrombocytosis, splenectomy, child

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Alina Grama

Arhiva autor

Andreea Durlan

Latest posts by Andreea Durlan (see all)

Articole semnate de acelasi autor in Revista Romana de Pediatrie:

TIMOMUL: O CAUZA RARA DE TUMORA MEDIASTINALA LA COPIL

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