Ileana Ioniuc

Latest posts by Ileana Ioniuc (see all)

PARTICULARITATI IN RINOSINUZITA CRONICA LA COPIL - 21/02/2017
PARTICULARITIES IN THE CHILD CHRONIC RHINOSINUSITIS - 21/02/2017
ATOPIA, FACTOR DE RISC IN APARITIA OTITEI SEROASE LA COPIL - 30/08/2016

Articole semnate de acelasi autor in Revista Romana de Pediatrie:

Chronic rhinosinusitis as a risk factor of difficult to control asthma. Therapeutical considerations

Revista Romana de PEDIATRIE | Volumul LX, Nr. 4, An 2011

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

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Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Magdalena M. Florea, Oana Lăzărescu, Ileana Ioniuc, Monica Alexoae, Aurica Rugina and Stela Gotia

ABSTRACT

Children with difficult to control asthma are a heterogeneous group. These cases need a review of diagnosis and evaluation of the different risk factors for loose control. There are known that nasal sinus disease may contribute to less control of asthma. The prevalence of chronic rhinosinusitis in the pediatric population is inversely related to the age of the patient. Many features of CRS are similar with those of viral upper respiratory tract infections or allergic rhinitis. That is why the diagnosis of CRS in this group can be more difficult to make. The effect on quality of life for chronic rhinosinusitis (CRS) in the pediatric population is also significant. Our study wants to prove that antibiotic treatment with antihistamines associated to combine asthma therapy in asthmatic children with chronic sinus disease may improve quality of life and lung function.

Methods: 31 children (ages between 8-18), with mild to severe persistent asthma and chronic rhinosinusitis were tested using tests of quality of life (Juniper 2001), ENT exam, sinus X-ray, eosinophyls and microbiological examination in sputum and nasal secretions, spirometry (Pony FX) before and after 3 month of combined anti-inflammatory and long acting beta agonist (GINA 2006) therapy, associated with a broad-spectrum antibiotic, nasal steroid and an oral antihistamine.

Results: after 3 month of combined therapy, quality testing of life was significantly improved, from symptomatic (p=0,024), activity (p=0,003) and emotional (p<0,001) point of view, as well as FEV1 (p<0,001), but has not MEF50 (p=0,105, p>0,05).The positive evolution was found in 28/31 cases. The pattern of inflammation in the airways was eosinophilic (3/21 cases tested), neutrophilic (13/21 cases tested), mixed (3/21 cases tested) and non-inflammatory (2/21 cases tested). The most common microbian agents found in sputum culture was Haemophylus influentzae (6/22 cases tested), Streptococcus pneumoniae (4/22 cases tested), Branhamella catharalis (7/22 cases tested).

Conclusions: the treatment of chronic rhinosinusitis (specific antibiotherapy, antihistamines) associated with aggressive treatment against eosinophylic inflammation of airways improve the quality of life and lung function of those children with difficult to control asthma.

Key words: chronic rhinosinusities, asthma, complex treatment, quality of life tests, pulmonary function

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Magdalena M. Florea

RINOSINUZITA CRONICA – FACTOR DE RISC PENTRU ASTMUL DIFICIL DE CONTROLAT LA COPIL

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Magdalena M. Florea, Oana Lăzărescu, Ileana Ioniuc, Monica Alexoae, Aurica Rugina and Stela Gotia

REZUMAT

Copiii cu astm dificil de controlat constituie un grup heterogen care necesită o reevaluare atentă în vederea identificării factorilor de risc care au condus la pierderea controlului. Sinuzitele reprezintă o categorie importantă în cadrul acestor factori. În populaţia pediatrică, prevalenţa, rinosinuzitelor cronice (RSC) este invers proporţională cu vârsta pacienţilor şi diagnosticul este dificil mai ales că multe dintre trăsăturile lor sunt asemănătoare infecţiilor de tract respirator sau rinitei alergice. RSC alterează calitatea vieţii bolnavului cu astm. Autorii abordează problematica asocierii RS – astm bronşic privind dificultăţile de diagnostic şi cele terapeutice, ca şi repercusiunile asupra controlului astmului bronşic şi asupra calităţii vieţii bolnavului.

Metodă: au fost luaţi în studiu 31 de copii (8-18 ani) cu astm bronşic necontrolat şi RSC. Protocolul de studiu a cuprins reevaluarea diagnosticului de astm bronşic cu stabilirea scorului de gravitate, examen ORL, radiografie de sinusuri, examinare citologică şi microbiologică din spută şi secreţiile nazale, spirometrie (Pony FX) şi au fost testaţi folosind testele standardizate de calitate a vieţii (PAQLQ – Juniper 2001), la început şi după 3 luni de terapie antiastmatică combinată anti-inflamatorie şi bronhodilatatoare (conform GINA 2006), asociată cu antibioterapie cu spectru larg, corticoid nazal, antihistaminic oral, educaţie individualizată.

Rezultate: reevaluarea după 3 luni a evidenţiat: îmbunătăţirea semnificativă a testelor de calitate a vieţii, din punct de vedere simptomatic (p=0,024), al activităţii (p=0,003) şi emoţional (p<0,001); s-a constatat o îmbunătăţire a FEV1 (p<0,001), dar nu şi a MEF50 (p=0,105, p>0,05). Evoluţie favorabilă au avut 28/31 de cazuri. Pattern-ul inflamator al căilor respiratorii superioare a fost eozinofilic în 3/21 cazuri, neutrofilic în 13/21 de cazuri, mixt în 3/21 de cazuri şi non-inflamator în 2/21 de cazuri. Examenul microbiologic (aplicat la 22 de cazuri) a izolat în ordinea frecvenţei Branhamella catharalis, Haemophylus influentzae, Streptococcus pneumoniae.

Concluzii: identificarea RSC la copilul cu astm bronşic necontrolat este o măsură obligatorie. Tratamentul rinosinuzitei cronice asociat tratamentului agresiv al inflamaţiei alergice (corticoterapie nazală şi inhalată) ameliorează net calitatea vieţii şi funcţia pulmonară.

Cuvinte-cheie: rinosinuzită cronică, astm bronşic, tratamentul complex, teste de calitatea vietii, funcţie pulmonare.

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Magdalena M. Florea

Risk factors for recurrent wheezing (WR) in young children

Revista Romana de PEDIATRIE | Volumul LXI, Nr. 2, An 2012

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Emanuela Arganisciuc, M. Colta, Ileana Ioniuc, Monica Alexoae, Alina Murgu, Aurica Rugina and Stela Gotia

ABSTRACT

Objective. Anamnestic, clinical and paraclinical evaluation of main predictive factors for the occurrence of recurrent wheezing in young children.

Method. The study included 387 children warded for the presence of wheezing and coughing, applying a complex scheme of exploration in order to detect the risk factors for recurrent wheezing and shape the diagnosis.

Results. The most common risk factors for recurrent wheezing identified in descending order of frequency, were: male gender (65.37%), young age at onset of symptoms (62.27% under 2 years o age), urban environment (56.04%), onset of symptoms in the winter (48.32%), frequent respiratory infections (39.01%), infant formula feeding (37.08%), passive smoking (25.58%), associated allergic manifestations (17.05%), family atopy (16.53%), allergic sensitization (11.11%).

Conclusions. The diagnosis of recurrent wheezing unaccompanied by family or personal atopy was the most common, medical history being dominated by viral infections at infant age and exposure to cigarette smoke. Male gender was predominant in all age groups. Positive familial allergological survey and allergic manifestations associated with recurrent wheezing prove the existence of early onset of respiratory allergy. The presence of recurrent wheezing requires a special dispensary system, especially in the atopic children, due to the risk of developing chronic allergic inflammation of the airways.

Key words: recurrent wheezing, child, risk factors, atopy

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Emanuela Arganisciuc

FACTORI DE RISC PENTRU WHEEZING RECURENT (WR) LA COPILUL MIC

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Emanuela Arganisciuc, M. Colta, Ileana Ioniuc, Monica Alexoae, Alina Murgu, Aurica Rugina and Stela Gotia

REZUMAT

Obiectiv. Evaluarea anamnestică, clinică şi paraclinică a principalilor factori predictivi pentru apariţia WR la vârstă mică.

Metodă. Au fost incluşi în studiu 387 de copii internaţi pentru prezenţa de wheezing şi tuse, aplicându-se o schemă complexă de explorare pentru depistarea factorilor de risc ai wheezing-ului recurent şi conturarea diagnosticului.

Rezultate. Principalii factori de risc pentru wheezing-ul recurent identificaţi în studiu, în ordinea frecvenţei, au fost: sexul masculin (65,37%), vârsta mică la debut (62,27% sub 2 ani), mediul urban (56,04%), debutul simptomatologiei în perioada de iarnă (48,32%), infecţiile respiratorii frecvente (39,01%), alimentaţia artificială (37,08%), fumatul pasiv (25,58%), manifestările alergice asociate (17,05%), atopia familială (16,53%), sensibilizarea alergică (11,11%).

Concluzii. Diagnosticul de wheezing recurent postbroşiolitic neînsoţit de atopie familială sau personală a fost cel mai frecvent, istoricul fiind dominat de infecţia virală la vârsta de sugar şi expunerea la fum de ţigară. Sexul masculin a fost dominant ca frecvenţă la toate grupele de vârstă. Ancheta alergologică familială pozitivă şi manifestările alergice asociate cu wheezing-ul recurent dovedesc existenţa debutului precoce al alergiei respiratorii. Prezenţa wheezing-ului recurent impune o dispensarizare specială, mai ales la cei atopici, datorită riscului crescut de inflamaţie cronică alergică în căile respiratorii.

Cuvinte cheie: wheezing recurent, copil, factori de risc, atopie

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Emanuela Arganisciuc

Specific serum IgE – marker for atopic sensitization and allergy in children. Case study

Revista Romana de PEDIATRIE | Volumul LXI, Nr. 3, An 2012

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Stela Gotia, Monica Alexoae, Ileana Ioniuc, Alina Murgu, Mihai Colţa, Liliana Profir and Aurica Rugina

ABSTRACT

Specific serum IgE elevated levels integrated in anamnesis and clinical context, make the diagnosis more precise and suggest the severity of the allergic diseases. Knowing the allergen could be predictive and is essential for the secondary prevention measures. Objective: determination of serum specific IgE in children of different ages with clinical manifestations of allergy, to assess the spectrum of allergens incriminated and their correlation with clinical diagnosis. Methods: retrospective study, 30 months (2007-2009) on 423 children diagnosed based on international criteria with different allergic diseases. Serum specific IgE was performed by a immunecromathographical quantitative assay QuantiScan. Results: Serum specific IgE values were positive in 71,39% cases (302 children) from all 423 children included in the study, more frequently in children under 6 years of age (61,25%). Polysensitizations were more frequently, especially to respiratory allergens, 66 children over 6 years (21,85%) and 43 young children (14,23%) and monosensitizations under 6 years old (Dermatophagoides 6,25% , cow’s milk - 5,62%). Respiratory allergy (bronchial asthma+/- allergic rhinitis) was correlated with polysensitizations, including also food allergens – 67%, more frequently in children over 6 years old. Atopic dermatitis was correlated mainly with food allergy (48%) in children under 3 years old. Incriminated allergens ( in order of frequency): cow’s milk, dermatophagoides, egg white, peanuts - under 6 years; dust, pollens, animal epithelia, peanuts – over 6 years old. Conclusions: specific serum IgE confirm the clinical diagnosis in most cases. Polysensitizations were detected in patients with systemic allergy symptoms. The allergens spectrum is characterised by the high frequency of polysensitizations and respiratory allergens sensitizations in young children.

Key words: specific IgE, allergy diseases, children

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Stela Gotia

IGE SPECIFICE SERICE – MARKERI AI SENSIBILIZARII ATOPICE SI ALERGIEI LA COPIL. STUDIU CAZUISTIC

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Stela Gotia, Monica Alexoae, Ileana Ioniuc, Alina Murgu, Mihai Colţa, Liliana Profir and Aurica Rugina

REZUMAT

Valorile crescute ale IgE serice specifice diferiţilor alergeni, integrate în contextul anamnestic şi clinic, aduc un plus de precizie diagnosticului şi sugerează severitatea bolilor alergice. Cunoaşterea alergenului poate avea valori predictive şi este esenţială pentru măsurile de profilaxie secundară. Obiectiv. Determinarea IgE serice specifice la copii de diferite vârste cu manifestări clinice de alergie, în vederea evaluării spectrului de alergeni incriminaţi şi corelarea lor cu diagnosticul clinic. Material şi metodă. Studiu retrospectiv, pe o perioadă de 30 luni (2007-2009) a 423 de bolnavi, diagnosticaţi cu diferite boli alergice, conform criteriilor recunoscute de forurile internaţionale. Dozarea IgE specifice s-a realizat printr-o metodă cantitativă imunocromatografi că - QuantiScan. Rezultate. Valorile IgE serice specifice au fost pozitive în 71,39% cazuri (302 copii) din totalul de 423 copii luaţi în studiu, mai frecvent la copiii sub 6 ani (61,25%). Polisensibilizările au fost mult mai des întâlnite, mai frecvent la aeroelergeni, 66 copii peste 6 ani (21,85%) şi 43 copii mici (14,23%), iar monosensibilizarea a fost mai frecventă la grupa de vârstă sub 6 ani (Dermatophagoides 6,25% şi lapte 5,62%). Alergia respiratorie (AB+/- RA) s-a corelat cu polisensibilizarea, inclusiv la alergeni alimentari – 67%, mai frecvent la grupa de vârstă peste 6 ani, iar dermatita atopică s-a corelat in principal cu alergia alimentară (48%) la grupa de vârstă sub 3 ani. Alergenii incriminaţi (în ordinea frecvenţei): sub 6 ani – lapte, dermatophagoides, albuş, alune; peste 6 ani – praf, polen, epitelii de animale, alune. Concluzii. IgE specific seric a confirmat diagosticul clinic în majoritatea cazurilor. Polisensibilizările s-au înregistrat cu precădere la bolnavi cu manifestări alergice de tip sistemic. Profilul sensibilizărilor din zona noastră geografică, determinat prin IgE specifice serice, se particularizează prin frecvenţa crescută a polisensibilizărilor şi prin implicarea aeroalergenilor la vârsta mică.

Cuvinte cheie: IgE specifice, boli alergice, copii

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Stela Gotia

Job Syndrome – Autosomal recessive type

Revista Romana de PEDIATRIE | Volumul LXI, Nr. 4, An 2012

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Monica Alexoae, Ileana Ioniuc, E. Carasievici, M. Covic and Stela Gotia

ABSTRACT

HiperIgE syndrome or Job syndrome is a rare primary immune deficiency with autosomal dominant or recessive transmission manifested by extreme hyperimmunoglobulinemia E with an increased incidence of infections and connective tissue abnormalities. The authors present one fatal case with severe symptoms since infancy, aggravated by chronic anemia and malnutrition, and exceed corticotherapy and antibiotherapy, included as an autosomal recessive type.

Key words: HiperIgE, infections, allergy

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Monica Alexoae

SINDROM JOB – FORMA AUTOSOMAL RECESIVA

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Monica Alexoae, Ileana Ioniuc, E. Carasievici, M. Covic and Stela Gotia

REZUMAT

Sindromul hiper-IgE (SHE), sau sindromul Job, este un deficit imun primar rar, cu transmitere autosomal dominantă sau recesivă care asociază hiperimunoglobulinemia E extremă cu o incidenţă crescută a infecţiilor şi modificări ale ţesutului conjunctiv. Este prezentat un caz cu manifestări severe încă din perioada de sugar, care se încadrează în forma autosomal recesivă, cu evoluţie fatală, agravată de anemia cronică şi malnutriţie, excesul de corticoterapie şi antibioterapie.

Cuvinte cheie: hiper-IgE, infecţii, alergie

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Monica Alexoae

Bronchial asthma in adolescence

Revista Romana de PEDIATRIE | Volumul LXII, Nr. 1, An 2013

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Ileana Ioniuc

ASTMUL BRONSIC LA ADOLESCENT

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Ileana Ioniuc, Monica Alexoae and Stela Gotia

REZUMAT

Abordarea astmului bronşic la adolescent este dificilă prin complexitatea factorilor de agravare (preexistente şi/ sau dobândite) şi non-complianţa la tratament. Autorii dezbat abordarea farmacologică şi non-farmacologică conform ghidurilor internaţionale şi circumstanţele eşecurilor în obţinerea controlului bolii, în condiţiile unor comorbidităţi alergice şi non-alergice.

Cuvinte cheie: astm bronşic, adolescent, comorbidităţi

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Ileana Ioniuc

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