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Oana Lăzărescu

Latest posts by Oana Lăzărescu (see all)

  • Risk factors for asthma in children (6-18 years) - 31/07/2015
  • FACTORI DE RISC PENTRU ASTMUL BRONSIC LA COPIL (6-18 ANI) - 31/07/2015
  • Chronic rhinosinusitis as a risk factor of difficult to control asthma. Therapeutical considerations - 31/07/2015

Articole semnate de acelasi autor in Revista Romana de Pediatrie:

Risk factors for asthma in children (6-18 years)

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Revista Romana de PEDIATRIE | Volumul LX, Nr. 4, An 2011
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

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Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

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Risk factors for asthma in children (6-18 years)

Oana Lăzărescu, Magdalena M. Florea, Ema Agarniciuc, Ileana Ioniuc, Monica Alexoae and Stela Gotia

ABSTRACT

Asthma is one of the most common diseases in children and an important cause of morbidity and mortality, with recent increased prevalence. Asthma diagnosis in children is often underestimated in early childhood. The aim of present study is to anamnestically assess using clinical and specific paraclinic exploration the incidence of the risk factors highly suggestive of asthma in children (6-18 years) and the correlation with disease severity. The questionnaires used in this study included relevant information to known risk factors for asthma during pre and postnatal period, preadolescence and adolescence stage. The principal risk factors for asthma identified in descending order of frequency were: personal atopy, recurrent wheezing, male gender, urban environment, indoor air allergens exposure (house dust, domestic animals, house mold) allergic sensitization to indoor allergens (house-dust mites), infant artificial feeding, family atopy, exposure to second hand tobacco smoke. Allergic polisensitization and tobacco smoke exposure are associated with severe asthma. The majority of cases were affected by asthma-related comorbid conditions and allergic rhinitis was the most frequent comorbidity.

Key words: asthma, child, risk factors, atopy

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Oana Lăzărescu

FACTORI DE RISC PENTRU ASTMUL BRONSIC LA COPIL (6-18 ANI)

SELECT ISSUE

Revista Romana de PEDIATRIE | Volumul LX, Nr. 4, An 2011
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

FACTORI DE RISC PENTRU ASTMUL BRONSIC LA COPIL (6-18 ANI)

Oana Lăzărescu, Magdalena M. Florea, Ema Agarniciuc, Ileana Ioniuc, Monica Alexoae and Stela Gotia

REZUMAT

Astmul bronşic este considerat una dintre din cele mai comune boli cronice ale copilului şi reprezintă o cauză importantă de morbiditate şi mortalitate, cu prevalenţă în creştere, conform estimărilor recente. La acest aspect contribuie subevaluarea diagnosticului la vârstă mică. Studiul îşi propune evaluarea anamnestică şi prin explorări clinico-paraclinice a incidenţei factorilor de risc sugestivi pentru suspiciunea de diagnostic de astm bronşic la copil, la vârsta de 6-18 ani, precum şi corelaţiile acestora cu gradul de severitate a bolii. Studiul a utililizat chestionare ce au inclus informaţii relevante pentru factorii de risc cunoscuţi ante şi postnatal precum şi cei asociaţi etapelor de viaţă preadolescent şi adolescent. Principalii factori de risc pentru astmul bronşic identificaţi în studiu (în ordinea frecvenţei) au fost: prezenţa atopiei personale, istoric de wheezing recurent, sexul masculin, mediul urban, expunerea la aeroalergeni de interior (praf, păr de animale, mucegai), sensibilizarea alergică la aeroalergeni (în special la acarieni), alimentaţia artificială, prezenţa atopiei familiale, fumatul pasiv. Polisensibilizarea alergică şi expunerea la fumul de ţigară se asociază cu forme mai severe de astm. Comorbidităţi alergice au fost prezente în majoritatea cazurilor, cea mai frecventă fiind rinita alergică (78%).

Cuvinte cheie: astm bronşic, copil, factori de risc, atopie

Full text | PDF

Oana Lăzărescu

Chronic rhinosinusitis as a risk factor of difficult to control asthma. Therapeutical considerations

SELECT ISSUE

Revista Romana de PEDIATRIE | Volumul LX, Nr. 4, An 2011
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Chronic rhinosinusitis as a risk factor of difficult to control asthma. Therapeutical considerations

Magdalena M. Florea, Oana Lăzărescu, Ileana Ioniuc, Monica Alexoae, Aurica Rugina and Stela Gotia

ABSTRACT

Children with difficult to control asthma are a heterogeneous group. These cases need a review of diagnosis and evaluation of the different risk factors for loose control. There are known that nasal sinus disease may contribute to less control of asthma. The prevalence of chronic rhinosinusitis in the pediatric population is inversely related to the age of the patient. Many features of CRS are similar with those of viral upper respiratory tract infections or allergic rhinitis. That is why the diagnosis of CRS in this group can be more difficult to make. The effect on quality of life for chronic rhinosinusitis (CRS) in the pediatric population is also significant. Our study wants to prove that antibiotic treatment with antihistamines associated to combine asthma therapy in asthmatic children with chronic sinus disease may improve quality of life and lung function.

Methods: 31 children (ages between 8-18), with mild to severe persistent asthma and chronic rhinosinusitis were tested using tests of quality of life (Juniper 2001), ENT exam, sinus X-ray, eosinophyls and microbiological examination in sputum and nasal secretions, spirometry (Pony FX) before and after 3 month of combined anti-inflammatory and long acting beta agonist (GINA 2006) therapy, associated with a broad-spectrum antibiotic, nasal steroid and an oral antihistamine.

Results: after 3 month of combined therapy, quality testing of life was significantly improved, from symptomatic (p=0,024), activity (p=0,003) and emotional (p<0,001) point of view, as well as FEV1 (p<0,001), but has not MEF50 (p=0,105, p>0,05).The positive evolution was found in 28/31 cases. The pattern of inflammation in the airways was eosinophilic (3/21 cases tested), neutrophilic (13/21 cases tested), mixed (3/21 cases tested) and non-inflammatory (2/21 cases tested). The most common microbian agents found in sputum culture was Haemophylus influentzae (6/22 cases tested), Streptococcus pneumoniae (4/22 cases tested), Branhamella catharalis (7/22 cases tested).

Conclusions: the treatment of chronic rhinosinusitis (specific antibiotherapy, antihistamines) associated with aggressive treatment against eosinophylic inflammation of airways improve the quality of life and lung function of those children with difficult to control asthma.

Key words: chronic rhinosinusities, asthma, complex treatment, quality of life tests, pulmonary function

Full text | PDF

Magdalena M. Florea

RINOSINUZITA CRONICA – FACTOR DE RISC PENTRU ASTMUL DIFICIL DE CONTROLAT LA COPIL

SELECT ISSUE

Revista Romana de PEDIATRIE | Volumul LX, Nr. 4, An 2011
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

RINOSINUZITA CRONICA – FACTOR DE RISC PENTRU ASTMUL DIFICIL DE CONTROLAT LA COPIL

Magdalena M. Florea, Oana Lăzărescu, Ileana Ioniuc, Monica Alexoae, Aurica Rugina and Stela Gotia

REZUMAT

Copiii cu astm dificil de controlat constituie un grup heterogen care necesită o reevaluare atentă în vederea identificării factorilor de risc care au condus la pierderea controlului. Sinuzitele reprezintă o categorie importantă în cadrul acestor factori. În populaţia pediatrică, prevalenţa, rinosinuzitelor cronice (RSC) este invers proporţională cu vârsta pacienţilor şi diagnosticul este dificil mai ales că multe dintre trăsăturile lor sunt asemănătoare infecţiilor de tract respirator sau rinitei alergice. RSC alterează calitatea vieţii bolnavului cu astm. Autorii abordează problematica asocierii RS – astm bronşic privind dificultăţile de diagnostic şi cele terapeutice, ca şi repercusiunile asupra controlului astmului bronşic şi asupra calităţii vieţii bolnavului.

Metodă: au fost luaţi în studiu 31 de copii (8-18 ani) cu astm bronşic necontrolat şi RSC. Protocolul de studiu a cuprins reevaluarea diagnosticului de astm bronşic cu stabilirea scorului de gravitate, examen ORL, radiografie de sinusuri, examinare citologică şi microbiologică din spută şi secreţiile nazale, spirometrie (Pony FX) şi au fost testaţi folosind testele standardizate de calitate a vieţii (PAQLQ – Juniper 2001), la început şi după 3 luni de terapie antiastmatică combinată anti-inflamatorie şi bronhodilatatoare (conform GINA 2006), asociată cu antibioterapie cu spectru larg, corticoid nazal, antihistaminic oral, educaţie individualizată.

Rezultate: reevaluarea după 3 luni a evidenţiat: îmbunătăţirea semnificativă a testelor de calitate a vieţii, din punct de vedere simptomatic (p=0,024), al activităţii (p=0,003) şi emoţional (p<0,001); s-a constatat o îmbunătăţire a FEV1 (p<0,001), dar nu şi a MEF50 (p=0,105, p>0,05). Evoluţie favorabilă au avut 28/31 de cazuri. Pattern-ul inflamator al căilor respiratorii superioare a fost eozinofilic în 3/21 cazuri, neutrofilic în 13/21 de cazuri, mixt în 3/21 de cazuri şi non-inflamator în 2/21 de cazuri. Examenul microbiologic (aplicat la 22 de cazuri) a izolat în ordinea frecvenţei Branhamella catharalis, Haemophylus influentzae, Streptococcus pneumoniae.

Concluzii: identificarea RSC la copilul cu astm bronşic necontrolat este o măsură obligatorie. Tratamentul rinosinuzitei cronice asociat tratamentului agresiv al inflamaţiei alergice (corticoterapie nazală şi inhalată) ameliorează net calitatea vieţii şi funcţia pulmonară.

Cuvinte-cheie: rinosinuzită cronică, astm bronşic, tratamentul complex, teste de calitatea vietii, funcţie pulmonare.

Full text | PDF

Magdalena M. Florea


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