Aurica Rugina

Latest posts by Aurica Rugina (see all)

OSTEOPENIA LA COPIII CU SINDROAME DE MALABSORBTIE - 22/02/2017
OSTEOPENIA IN CHILDREN WITH MALABSORPTION SYNDROM - 22/02/2017
ATOPIA, FACTOR DE RISC IN APARITIA OTITEI SEROASE LA COPIL - 30/08/2016

Articole semnate de acelasi autor in Revista Romana de Pediatrie:

OSTEOPENIA LA COPIII CU SINDROAME DE MALABSORBTIE

Revista Romana de PEDIATRIE | Volumul LXV, Nr. 4, An 2016

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Tania Elena Rusu, Evelina Moraru, Laura Bozomitu, Dana Teodora Anton Păduraru, Lucretia Anghel and Aurica Rugina

REZUMAT

Introducere. Sindroamele de malabsorbţie au drept consecinţă perturbarea dezvoltării şi funcţiei normale a sistemului osos.
Obiective. Aprecierea densităţii osoase la copiii cu sindroame de malabsorbţie. Analiza factorilor de risc pentru osteopenie. Evaluarea corelaţiilor între osteopenie, markerii nutriţionali şi markerii metabolismului osos.
Material şi metodă. 118 copii cu sindrom de malabsorbţie de diverse etiologii, în principal boală celiacă (41 cazuri) şi fibroză chistică (14 cazuri). Densitatea osoasă a fost evaluată prin Ultrasonografie cantitativă (QUS) utilizând un Osteodensitometru Sunlight Omnisense Ultrasonometer 7000P. QUS a fost efectuată la radius (86 de cazuri) şi tibie (78 de cazuri). 25 hidroxivitamina D a fost evaluată la 10 cazuri prin metoda RIA. Analiza statistică a fost realizată utilizând SPSS for Windows.
Rezultate. Osteopenia a fost prezentă la 32% dintre cazuri. Scăderea densităţii osoase la radius a fost asociată cu sindromul celiachiform. Osteopenia la tibie s-a asociat cu fibroza chistică. Osteopenia a fost mai frecventă la fete. Osteopenia s-a asociat cu durata bolii. Osteopenia nu s-a corelat cu BMI. Scorul Z la radius s-a corelat pozitiv cu nivelele fosfatazei alcaline, iar scorul Z la tibie cu colesterolemia. Scorul Z la tibie şi radius s-a corelat negativ cu valorile markerilor inflamatori. La copiii cu boală celiacă, valoarea anticorpilor anti-transglutaminază s-a corelat negativ cu scorul Z la radius şi tibie. Nivelele 25(OH) vitaminei D au fost deficiente la 8 copii şi insuficiente la 2, dar valorile sale nu s-au corelat cu scorul Z la radius şi tibie. Semne clinice, biologice şi radiologice de rahitism au fost prezente la 35% dintre bolnavii cu osteopenie.
Concluzii. Osteopenia a fost prezentă la 1/3 din bolnavii cu sindrom de malabsorbţie din lotul studiat. 30% dintre bolnavi au avut semne clinice, biologice şi radiologice de rahitism. Valorile 25(OH) vitaminei D nu s-au corelat cu scorul Z. S-a observat o corelaţie negativă între parametrii osoşi şi markerii inflamaţiei şi anticorpii anti-transglutaminază.

Cuvinte cheie: osteopenie, sindroame de malabsorbţie, boală celiacă

Full text | PDF

Tania Elena Rusu

OSTEOPENIA IN CHILDREN WITH MALABSORPTION SYNDROM

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Tania Elena Rusu, Evelina Moraru, Laura Bozomitu, Dana Teodora Anton Păduraru, Lucretia Anghel and Aurica Rugina

ABSTRACT

Introduction. Malabsorption syndromes result in the disturbance of bone normal development and function.
Objective. The assessment of bone density in children with malabsorption syndromes. The analysis of risk factors for osteopenia. The correlation between osteopenia, nutritional markers and bone metabolism markers.
Material and method. 118 children with malabsorbtion syndromes of different etiologies, mainly Celiac disease (41 cases) and Cystic fibrosis (14 cases). Bone density was assessed by Quantitative Ultrasonography (QUS) with a Sunlight Omnisense Ultrasonometer 7000P. QUS was performed at two sites – radius (86 cases) and tibia (78 cases). 25hydroxivitamin D was measured in 10 cases by RIA method. Statistical analysis was made using SPSS for Windows.
Results. Osteopenia was present in 32% cases. Decreased bone density at the radius was associated with the celiac syndrome. Osteopenia at the tibia was associated with cystic fibrosis. Osteopenia was more frequent in girls. Osteopenia was related to the duration of the disease. Osteopenia wasn’t related to BMI. Radius Z-score positively correlated to alkaline phosphatase levels and tibia Z-score to serum cholesterol levels. Radius and tibia Z-score negatively correlated with inflammatory marker levels. In children with celiac disease, the value of anti-transglutaminase antibodies was negatively correlated to radius and tibia Z-score values. 25(OH) vitamin D values were deficient in 8 patient and insufficient in 2, but its values didn’t correlate to radius/tibia Z-score. Clinical, biological and radiological signs of rickets were found in 35% of patients with osteopenia.
Conclusions. Osteopenia was found in 1/3 of patients with malabsorption syndromes of the studied group. In 30% of patients, clinical, biological and radiologic rickets signs were present. 25(OH) vitamin D values didn’t correlate with the Z-score. A negative correlation between bone parameters and inflammation markers and anti-transglutaminase antibodies values was observed.

Keywords: osteopenia, malabsorption syndromes, celiac disease

Full text | PDF

Tania Elena Rusu

ATOPIA, FACTOR DE RISC IN APARITIA OTITEI SEROASE LA COPIL

Revista Romana de PEDIATRIE | Volumul LXV, Nr. 2, An 2016

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Alice Azoicăi, Alina Murgu, Aurica Rugina, Bogdan Stana, Ileana Ioniuc, Irina Criscov, Monica Alexoae and Paula Popovici

ABSTRACT

Otita medie seroasă cronică, cauză majoră a hipoacuziei în perioada copilăriei, este frecvent asociată cu sensibilizarea alergică. Prevalenţa în continuă creştere a atopiei la această vârstă implică o abordare multidisciplinară a copiilor cu adenoidite, otite recurente şi disfuncţii tubare, în vederea unui management patogenic complex.
Obiectivul studiului a constat în determinarea asocierii otitelor medii cu bolile alergice, şi implicaţiile acestei asocieri în tratamentul şi evoluţia pacienţilor.
Material şi metodă. S-a realizat un studiu retrospectiv care a inclus 92 de copii, cu vârste cuprinse între 6 luni şi 6 ani internaţi în Clinica II Pediatrie, Spitalul Clinic de Copii „Sf. Maria“, Iaşi, cu diagnosticul de otită medie, pe o perioadă de 1 an (ianuarie 2015 – ianuarie 2016).
Rezultate. Majoritatea cazurilor au fost otite supurate (61 de pacienţi), 31 de cazuri au fost otite seroase, dintre care 23 au fost recurente. Asocierea cu bolile alergice a fost mai frecventă la copiii cu otită seroasă (26/31 cazuri). 4 pacienţi cu otită supurată au prezentat reacţii adverse la antibiotice, cu implicaţii majore în evoluţia cazurilor. Asocierea cu refluxul gastroesofagian a fost relativ asemănătoare între cele 2 loturi (11/61 de cazuri şi respectiv 10/31 de cazuri), la 10 pacienţi atopici, obiectivându-se alergia la proteinele laptelui de vacă.
În concluzie, copiii cu otite medii, în special cei cu otite medii seroase recurente ar trebui investigaţi pentru determinarea coexistenţei atopiei şi a refluxului gastroesofagian, eventual cu dozarea markerilor de inflamaţie alergică sau a pepsinei în exsudatul otic, în vederea unui management terapeutic ţintit.

Keywords: otită seroasă, alergie, copii

Full text | PDF

Alice Azoicăi

ATOPY, RISK FACTOR FOR OTITIS MEDIA WITH EFFUSION

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Alice Azoicăi, Alina Murgu, Aurica Rugina, Bogdan Stana, Ileana Ioniuc, Irina Criscov, Monica Alexoae and Paula Popovici

ABSTRACT

Chronic otitis, one of the major causes of pediatric hypoacusia is frequent associated with some allergic diseases. The continuous rice of atopic diseases prevalence in childhood, involves a multidisciplinary approach of Eustachian tube dysfunction, adenoid inflammation or recurrent otitis, for a complex pathogenic management.
The objective of this study was to determinate the association between otitis media and the allergic diseases with the implication in the treatment and evolution of this patients.
Methods. Retrospective study on 92 children, between 6 month and 6 years, admitted in II Pediatric Clinic, Clinical Hospital of Children “Sf. Maria” Iasi with diagnosis of acute otitis media, for a period of 1 year.
Results. Majority of cases (61patients) have been suppurate otitis, 31 cases have been otitis media with effusion out of which 23 have been recurrent. Association with allergic diseases has been more frequent in children with serous otitis media (26/31 cases). 4 cases with suppurate otitis media have developed adverse reaction to antibiotics with major implication in the cases evolution. Association with gastroesophageal reflux was relatively similar between cases with serous otitis and the suppurate ones (10/31 cases and 11/61 cases). From the atopic patients with gastroesophageal reflux, 10 presented cow’s milk protein allergy.
In conclusion, the children with otitis media, especially those with recurrent none suppurate form should be investigated for atopy and, eventually, for gastroesophageal reflux, possibly with determination of the allergic markers or of pepsin in the otic exudates, in order to a targeted therapeutic management.

Keywords: otitis, effusion, allergy, children

Full text | PDF

Alice Azoicăi

Scleroderma in young children

Revista Romana de PEDIATRIE | Volumul LX, Nr. 2, An 2011

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Ileana Ioniuc, Stela Gotia, Evelina Moraru, Aurica Rugina, Alina Murgu and Monica Alexoae

ABSTRACT

Chronic disease of unknown etiology, scleroderma represents a disease that occurs rarely in young children, with an estimated frequency of less than 1% up to age 5. Evolution of scleroderma is variable, unpredictable and the delineation of clinical forms in children is difficult. Some patients may experience periods of calm for many years, others have a progressive worsening, without remission and death. Our case is characterized by the onset at a young age, bringing together major and minor criteria for systemic scleroderma.

Key words: systemic scleroderma, young children

Full text | PDF

Ileana Ioniuc

SCLERODERMIA LA COPILUL MIC

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Ileana Ioniuc, Stela Gotia, Evelina Moraru, Aurica Rugina, Alina Murgu and Monica Alexoae

REZUMAT

Boală cronică de etiologie necunoscută, sclerodermia este o boală care apare rar la copilul mic, estimându-se o frecvenţă de sub 1% până la vârsta de 5 ani. Evoluţia cazurilor de sclerodermie este variabilă, imprevizibilă, delimitarea formelor clinice fiind dificilă la copil. Unii bolnavi pot prezenta perioade de acalmie mai mulţi ani, alţii au o evoluţie progresivă spre agravare (fără remisiuni) şi deces. Cazul prezentat se particularizează prin debutul sclerodermiei la vârstă mică, bolnavul întrunind, la 1 an si 3 luni, criterii majore şi minore de sclerodermie sistemică.

Cuvinte cheie: sclerodermie sistemică, copil mic

Full text | PDF

Ileana Ioniuc

Juvenile idiopathic arthritis – risk factors and clinical forms

Revista Romana de PEDIATRIE | Volumul LX, Nr. 4, An 2011

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Elena Simona Tucaliuc, C. Ailioaie, Aurica Rugina, Alina Murgu, Ileana Ioniuc and Stela Gotia

ABSTRACT

The aim of this article is to determine the JIA’s risk factors and the prevalence of clinical forms, poiting out the difficulties of situating them at onset as well as in evolution taking into consideration a significant number of patients (169 cases). The outlined clinical forms (in order of frequency) were: oligoarthritis (44,17%), RFnegative polyarthritis (33.13%), enthesitis (11.24%), systemic arthritis (5.91%), RF-positive polyarthritis (2, 95%) and psoriatic arthritis (2.36%), with the percentage values close to those of other studies, except the RF-negative polyarthritis subtype in which the frequency is higher. Individualized analysis of cases revealed real time from onset of disease to diagnosis and risk factors for JIA (in order of frequency): traumatic (9,46%), positive family history (5,32%) and infections (2,35%). Also, it emphasized the possibility of transforming a clinical form to another even under adequate treatment.

Key words: juvenile idiopathic arthritis, risk factors, clinical forms

Full text | PDF

Elena Simona Tucaliuc

ARTRITA JUVENILA IDIOPATICA – FACTORI DE RISC SI FORME CLINICE. STUDIU CAZUISTIC

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Elena Simona Tucaliuc, C. Ailioaie, Aurica Rugina, Alina Murgu, Ileana Ioniuc and Stela Gotia

REZUMAT

Obiectivul este de a stabili factorii de risc şi prevalenţa formelor clinice de AJI cu evidenţierea dificultăţilor de încadrare la debut şi în evoluţie luând în studiu un lot semnificativ de bolnavi (169 cazuri). Formele clinice conturate (în ordinea frecvenţei) au fost: oligoarticulară (44,17%), poliarticulară cu FR negativ (33,13), entezită (11,24%), sistemică (5,91%), poliarticulară cu FR pozitiv (2,95%) şi psoriazică (2,36%). Analiza individualizată a cazuisticii a scos în evidenţă durata de la debutul real al bolii până la diagnostic, cât şi factorii de risc pentru AJI (în ordinea frecvenţei): traumatici (9,46%), antecedente familiale pozitive (5,32%) şi infecţioşi (2,36%). De asemenea, a fost evidenţiată posibilitatea transformării unei forme clinice în alta chiar sub tratament adecvat.

Cuvinte cheie: artrită juvenilă idiopatică, factori de risc, forme clinice

Full text | PDF

Elena Simona Tucaliuc

Chronic rhinosinusitis as a risk factor of difficult to control asthma. Therapeutical considerations

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Magdalena M. Florea, Oana Lăzărescu, Ileana Ioniuc, Monica Alexoae, Aurica Rugina and Stela Gotia

ABSTRACT

Children with difficult to control asthma are a heterogeneous group. These cases need a review of diagnosis and evaluation of the different risk factors for loose control. There are known that nasal sinus disease may contribute to less control of asthma. The prevalence of chronic rhinosinusitis in the pediatric population is inversely related to the age of the patient. Many features of CRS are similar with those of viral upper respiratory tract infections or allergic rhinitis. That is why the diagnosis of CRS in this group can be more difficult to make. The effect on quality of life for chronic rhinosinusitis (CRS) in the pediatric population is also significant. Our study wants to prove that antibiotic treatment with antihistamines associated to combine asthma therapy in asthmatic children with chronic sinus disease may improve quality of life and lung function.

Methods: 31 children (ages between 8-18), with mild to severe persistent asthma and chronic rhinosinusitis were tested using tests of quality of life (Juniper 2001), ENT exam, sinus X-ray, eosinophyls and microbiological examination in sputum and nasal secretions, spirometry (Pony FX) before and after 3 month of combined anti-inflammatory and long acting beta agonist (GINA 2006) therapy, associated with a broad-spectrum antibiotic, nasal steroid and an oral antihistamine.

Results: after 3 month of combined therapy, quality testing of life was significantly improved, from symptomatic (p=0,024), activity (p=0,003) and emotional (p<0,001) point of view, as well as FEV1 (p<0,001), but has not MEF50 (p=0,105, p>0,05).The positive evolution was found in 28/31 cases. The pattern of inflammation in the airways was eosinophilic (3/21 cases tested), neutrophilic (13/21 cases tested), mixed (3/21 cases tested) and non-inflammatory (2/21 cases tested). The most common microbian agents found in sputum culture was Haemophylus influentzae (6/22 cases tested), Streptococcus pneumoniae (4/22 cases tested), Branhamella catharalis (7/22 cases tested).

Conclusions: the treatment of chronic rhinosinusitis (specific antibiotherapy, antihistamines) associated with aggressive treatment against eosinophylic inflammation of airways improve the quality of life and lung function of those children with difficult to control asthma.

Key words: chronic rhinosinusities, asthma, complex treatment, quality of life tests, pulmonary function

Full text | PDF

Magdalena M. Florea

RINOSINUZITA CRONICA – FACTOR DE RISC PENTRU ASTMUL DIFICIL DE CONTROLAT LA COPIL

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Magdalena M. Florea, Oana Lăzărescu, Ileana Ioniuc, Monica Alexoae, Aurica Rugina and Stela Gotia

REZUMAT

Copiii cu astm dificil de controlat constituie un grup heterogen care necesită o reevaluare atentă în vederea identificării factorilor de risc care au condus la pierderea controlului. Sinuzitele reprezintă o categorie importantă în cadrul acestor factori. În populaţia pediatrică, prevalenţa, rinosinuzitelor cronice (RSC) este invers proporţională cu vârsta pacienţilor şi diagnosticul este dificil mai ales că multe dintre trăsăturile lor sunt asemănătoare infecţiilor de tract respirator sau rinitei alergice. RSC alterează calitatea vieţii bolnavului cu astm. Autorii abordează problematica asocierii RS – astm bronşic privind dificultăţile de diagnostic şi cele terapeutice, ca şi repercusiunile asupra controlului astmului bronşic şi asupra calităţii vieţii bolnavului.

Metodă: au fost luaţi în studiu 31 de copii (8-18 ani) cu astm bronşic necontrolat şi RSC. Protocolul de studiu a cuprins reevaluarea diagnosticului de astm bronşic cu stabilirea scorului de gravitate, examen ORL, radiografie de sinusuri, examinare citologică şi microbiologică din spută şi secreţiile nazale, spirometrie (Pony FX) şi au fost testaţi folosind testele standardizate de calitate a vieţii (PAQLQ – Juniper 2001), la început şi după 3 luni de terapie antiastmatică combinată anti-inflamatorie şi bronhodilatatoare (conform GINA 2006), asociată cu antibioterapie cu spectru larg, corticoid nazal, antihistaminic oral, educaţie individualizată.

Rezultate: reevaluarea după 3 luni a evidenţiat: îmbunătăţirea semnificativă a testelor de calitate a vieţii, din punct de vedere simptomatic (p=0,024), al activităţii (p=0,003) şi emoţional (p<0,001); s-a constatat o îmbunătăţire a FEV1 (p<0,001), dar nu şi a MEF50 (p=0,105, p>0,05). Evoluţie favorabilă au avut 28/31 de cazuri. Pattern-ul inflamator al căilor respiratorii superioare a fost eozinofilic în 3/21 cazuri, neutrofilic în 13/21 de cazuri, mixt în 3/21 de cazuri şi non-inflamator în 2/21 de cazuri. Examenul microbiologic (aplicat la 22 de cazuri) a izolat în ordinea frecvenţei Branhamella catharalis, Haemophylus influentzae, Streptococcus pneumoniae.

Concluzii: identificarea RSC la copilul cu astm bronşic necontrolat este o măsură obligatorie. Tratamentul rinosinuzitei cronice asociat tratamentului agresiv al inflamaţiei alergice (corticoterapie nazală şi inhalată) ameliorează net calitatea vieţii şi funcţia pulmonară.

Cuvinte-cheie: rinosinuzită cronică, astm bronşic, tratamentul complex, teste de calitatea vietii, funcţie pulmonare.

Full text | PDF

Magdalena M. Florea

SELECT ISSUE

Indexed

HIGHLIGHTS

SELECT ISSUE

Indexed

HIGHLIGHTS

SELECT ISSUE

Indexed

HIGHLIGHTS

SELECT ISSUE

Indexed

HIGHLIGHTS

SELECT ISSUE

Indexed

HIGHLIGHTS

SELECT ISSUE

Indexed

HIGHLIGHTS

SELECT ISSUE

Indexed

HIGHLIGHTS

SELECT ISSUE

Indexed

HIGHLIGHTS

SELECT ISSUE

Indexed

HIGHLIGHTS

SELECT ISSUE

Indexed

HIGHLIGHTS