Evelina Moraru

Latest posts by Evelina Moraru (see all)

OSTEOPENIA LA COPIII CU SINDROAME DE MALABSORBTIE - 22/02/2017
OSTEOPENIA IN CHILDREN WITH MALABSORPTION SYNDROM - 22/02/2017
PARTICULARITATI IN RINOSINUZITA CRONICA LA COPIL - 21/02/2017

Articole semnate de acelasi autor in Revista Romana de Pediatrie:

OSTEOPENIA LA COPIII CU SINDROAME DE MALABSORBTIE

Revista Romana de PEDIATRIE | Volumul LXV, Nr. 4, An 2016

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Tania Elena Rusu, Evelina Moraru, Laura Bozomitu, Dana Teodora Anton Păduraru, Lucretia Anghel and Aurica Rugina

REZUMAT

Introducere. Sindroamele de malabsorbţie au drept consecinţă perturbarea dezvoltării şi funcţiei normale a sistemului osos.
Obiective. Aprecierea densităţii osoase la copiii cu sindroame de malabsorbţie. Analiza factorilor de risc pentru osteopenie. Evaluarea corelaţiilor între osteopenie, markerii nutriţionali şi markerii metabolismului osos.
Material şi metodă. 118 copii cu sindrom de malabsorbţie de diverse etiologii, în principal boală celiacă (41 cazuri) şi fibroză chistică (14 cazuri). Densitatea osoasă a fost evaluată prin Ultrasonografie cantitativă (QUS) utilizând un Osteodensitometru Sunlight Omnisense Ultrasonometer 7000P. QUS a fost efectuată la radius (86 de cazuri) şi tibie (78 de cazuri). 25 hidroxivitamina D a fost evaluată la 10 cazuri prin metoda RIA. Analiza statistică a fost realizată utilizând SPSS for Windows.
Rezultate. Osteopenia a fost prezentă la 32% dintre cazuri. Scăderea densităţii osoase la radius a fost asociată cu sindromul celiachiform. Osteopenia la tibie s-a asociat cu fibroza chistică. Osteopenia a fost mai frecventă la fete. Osteopenia s-a asociat cu durata bolii. Osteopenia nu s-a corelat cu BMI. Scorul Z la radius s-a corelat pozitiv cu nivelele fosfatazei alcaline, iar scorul Z la tibie cu colesterolemia. Scorul Z la tibie şi radius s-a corelat negativ cu valorile markerilor inflamatori. La copiii cu boală celiacă, valoarea anticorpilor anti-transglutaminază s-a corelat negativ cu scorul Z la radius şi tibie. Nivelele 25(OH) vitaminei D au fost deficiente la 8 copii şi insuficiente la 2, dar valorile sale nu s-au corelat cu scorul Z la radius şi tibie. Semne clinice, biologice şi radiologice de rahitism au fost prezente la 35% dintre bolnavii cu osteopenie.
Concluzii. Osteopenia a fost prezentă la 1/3 din bolnavii cu sindrom de malabsorbţie din lotul studiat. 30% dintre bolnavi au avut semne clinice, biologice şi radiologice de rahitism. Valorile 25(OH) vitaminei D nu s-au corelat cu scorul Z. S-a observat o corelaţie negativă între parametrii osoşi şi markerii inflamaţiei şi anticorpii anti-transglutaminază.

Cuvinte cheie: osteopenie, sindroame de malabsorbţie, boală celiacă

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Tania Elena Rusu

OSTEOPENIA IN CHILDREN WITH MALABSORPTION SYNDROM

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Tania Elena Rusu, Evelina Moraru, Laura Bozomitu, Dana Teodora Anton Păduraru, Lucretia Anghel and Aurica Rugina

ABSTRACT

Introduction. Malabsorption syndromes result in the disturbance of bone normal development and function.
Objective. The assessment of bone density in children with malabsorption syndromes. The analysis of risk factors for osteopenia. The correlation between osteopenia, nutritional markers and bone metabolism markers.
Material and method. 118 children with malabsorbtion syndromes of different etiologies, mainly Celiac disease (41 cases) and Cystic fibrosis (14 cases). Bone density was assessed by Quantitative Ultrasonography (QUS) with a Sunlight Omnisense Ultrasonometer 7000P. QUS was performed at two sites – radius (86 cases) and tibia (78 cases). 25hydroxivitamin D was measured in 10 cases by RIA method. Statistical analysis was made using SPSS for Windows.
Results. Osteopenia was present in 32% cases. Decreased bone density at the radius was associated with the celiac syndrome. Osteopenia at the tibia was associated with cystic fibrosis. Osteopenia was more frequent in girls. Osteopenia was related to the duration of the disease. Osteopenia wasn’t related to BMI. Radius Z-score positively correlated to alkaline phosphatase levels and tibia Z-score to serum cholesterol levels. Radius and tibia Z-score negatively correlated with inflammatory marker levels. In children with celiac disease, the value of anti-transglutaminase antibodies was negatively correlated to radius and tibia Z-score values. 25(OH) vitamin D values were deficient in 8 patient and insufficient in 2, but its values didn’t correlate to radius/tibia Z-score. Clinical, biological and radiological signs of rickets were found in 35% of patients with osteopenia.
Conclusions. Osteopenia was found in 1/3 of patients with malabsorption syndromes of the studied group. In 30% of patients, clinical, biological and radiologic rickets signs were present. 25(OH) vitamin D values didn’t correlate with the Z-score. A negative correlation between bone parameters and inflammation markers and anti-transglutaminase antibodies values was observed.

Keywords: osteopenia, malabsorption syndromes, celiac disease

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Tania Elena Rusu

PARTICULARITATI IN RINOSINUZITA CRONICA LA COPIL

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Alina Murgu, Evelina Moraru, Daniela Rusu, Elena Macsim, Ileana Ioniuc, Bogdan Stana and Alice Azoicăi

REZUMAT

Rinosinuzita cronică (RSC), este o patologie rară în pediatrie comparativ cu adultul. Manifestările clinice sunt în relaţie, pe de o parte, cu particularităţile anatomice, iar pe de altă parte, cu cele de răspuns imun corelate cu vârsta copilului. Alergia constituie cauza principală în 50% dintre rinitele copilului, 40% dintre acestea debutând precoce până la vârsta de 6 ani. Expresia clinică a rinosinuzitei alergice la copil poate fi uneori însoţită de manifestări ale comorbidităţilor alergice asociate sau de complicaţii de vecinătate. Alterarea clearance-ului mucociliar poate fi însă indus şi de alte situaţii patologice mai rare care produc modificarea proprietăţilor reologice ale mucusului, ca în mucoviscidoză (FC). Prin heterogenitatea de expresie clinică în relaţie pe de o parte cu particularităţile de răspuns imunogenetic şi anatomice raportate la vârsta copilului şi pe de altă parte cu diversitatea factorilor etiologici inductori (de la foarte frecvenţi, precum alergia, la foarte puţin frecvenţi, FC), RSC impune un diagnostic corect, precoce şi un tratament adecvat prin colaborarea în echipă multidisciplinară.

Cuvinte cheie: rinosinuzită, copil, fibroza chistică, alergie

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Alina Murgu

PARTICULARITIES IN THE CHILD CHRONIC RHINOSINUSITIS

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Alina Murgu, Evelina Moraru, Daniela Rusu, Elena Macsim, Ileana Ioniuc, Bogdan Stana and Alice Azoicăi

ABSTRACT

Chronic rhinosinusitis is a rare pathology in pediatric pathology versus adult patients. Clinical manifestations are related, on the one hand, with the anatomical particularities and, on the other hand, with the immune response correlated with the age of the child. Allergy is the main cause in 50% of child rhinitis, 40% of them debuting early until the age of 6 years. The clinical expression of allergic rhinosinusitis in children can sometimes be accompanied by comorbidity manifestations or complications. Impaired mucociliary clearance can be induced by other rare pathological situations that produce mucus rheology modification, as in cystic fibrosis (CF). Through, the clinical heterogenicity of expression is in relation, on the one hand, with immunogenic response and anatomical particularities relative to age of the child, and secondly with the diversity of inducing factors (from very frequent like allergy to the least frequent, CF). It requires a correct diagnosis, early and appropriate treatment by a multidisciplinary team collaboration.

Keywords: rhinosinusitis, child, cystic fibrosis, allergy

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Alina Murgu

OBEZITATEA SI DISLIPIDEMIILE LA COPILUL CU HEPATITA CRONICA

Revista Romana de PEDIATRIE | Volumul LXV, Nr. 2, An 2016

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Alice N. Azoicai, Alina M. Murgu, Bogdan A. Stana, Evelina Moraru, Ileana K. Ioniuc, Irina Criscov, Monica M. Alexoae and Paula Popovici

REZUMAT

Asocierea hepatitelor cronice cu diverse tipuri de dislipidemii este o realitate nu numai pentru pacientul obez, la care ne aşteptăm să găsim hipercolesterolemii sau/şi hipertrigliceridemii, dar şi pentru copilul normoponderal. Cauzele acestei asocieri sunt multiple, însă trebuie să avem în vedere, în primul rând, predispoziţia familială şi transmiterea genetică a unor forme de dislipidemii. În acelaşi timp, unele dislipidemii sunt secundare hepatopatiilor cronice, astfel că se formează un cerc vicios în care tratamentul de primă intenţie a dezechilibrelor metabolice este de mare importanţă în succesul terapiei antivirale.

Cuvinte cheie: hepatită, dislipidemie, obezitate, copil

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Alice N. Azoicai

OBESITY AND DYSLIPIDEMIA IN CHILDREN WITH CHRONIC HEPATITIS

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Alice N. Azoicai, Alina M. Murgu, Bogdan A. Stana, Evelina Moraru, Ileana K. Ioniuc, Irina Criscov, Monica M. Alexoae and Paula Popovici

ABSTRACT

Chronic hepatitis association with various types of dyslipidemia is a reality not only for the obese pediatric patient, in which we expect to find hypercholesterolemia and / or hypertriglyceridemias, but also for normal weight children with hepatitis. The causes of this association are multiple, but we need to consider first the innate predisposition and transmission of genetic forms of dyslipidemia. Meanwhile, some secondary dyslipidemia are chronic liver disease related. Those considerations are forming a vicious circle in which primary treatment of metabolic imbalances has a great importance for the success of antiviral therapy.

Keywords: hepatitis, dyslipidemia, obesity, children

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Alice N. Azoicai

DERMATITA ATOPICA – DISFUNCTIA IMUNA ASOCIATA ATOPIEI

Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 4, An 2015

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Sempronia Ecaterina Coclici, Dana Elena Mîndru, Vasile Valeriu Lupu, Evelina Moraru and Laura Iulia Bozomitu

REZUMAT

Sistemul imunitar joacă un rol complex în apărarea organismului ca răspuns la „non-self“, răspunde anormal la antigenii alergeni (hipersensibilitate şi autoimunitate) şi este caracterizat prin toleranţă imună cu lipsa de reactivitate la propriile structuri (auto).

Scop. Scopul acestui studiu este de a demonstra că, în dermatita atopică, deficitul imun influenţează dezvoltarea atopiei, severitatea bolii şi dezvoltarea de comorbidităţi.

Material şi metode. În urma analizei foilor de observaţie, 135 de cazuri diagnosticate cu AD au fost incluse în studiu. Analiza statistică a fost realizată cu ajutorul SPSS V20 pentru determinarea frecvenţei şi testarea ipotezelor, pentru p <0,05, prin testele T şi OneWay ANOVA.

Rezultate. Din cele 135 de cazuri, 51,9% au fost copii de sex masculin şi 48,1% de copii de sex feminin, cu vârsta cuprinsă între 1 lună şi 127 luni, cu o medie de 26,21. Potrivit IgE serice totale, 64,4% dintre pacienţi au avut niveluri ridicate de IgE, 35,6% niveluri normale. În conformitate cu SCORAD, copiii au avut forma uşoară în 20,7% din cazuri, forma moderată în 70,4%, iar severă în 8,9% din cazuri. Deficitul de IgA a fost găsit în 48,1% din cazuri, iar deficitul de IgG a fost găsit în 38,5% din cazuri. Testele t de corelaţie pe eşantioane independente constată valori semnificative statistic între nivelul IgE şi deficitul de IgA, între SCORAD şi deficitul de IgG şi IgA. Marşul atopic este influenţat de valorile crescute ale IgE şi deficitul de IgA pentru un p<0,05.

Concluzii. Atopia în DA poate fi influenţată de factori complecşi, atât interni, cât şi de mediu, dar acest lucru rămâne un subiect controversat. Factorii externi care acţionează pe un fundal genetic predispus la atopie poate declanşa manifestarea DA.

Cuvinte cheie: dermatită atopică, deficit imun, IgE, IgA, IgG

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Sempronia Ecaterina Coclici

ATOPIC DERMATITIS – ASSOCIATED IMMUNE DYSFUNCTION

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Sempronia Ecaterina Coclici, Dana Elena Mîndru, Vasile Valeriu Lupu, Evelina Moraru and Laura Iulia Bozomitu

ABSTRACT

The immune system shows a complex role to defend the body in response to “non-self” antigens, respond abnormally to antigens allergens (hypersensitivity and autoimmunity) and shows immune tolerance by lack of reactivity to its own structures (self).

Aim. The aim of this study is to demonstrate that in atopic dermatitis immune deficiency influences the development of atopy, disease severity and comorbidities.

Material and methods. Following medical record review, 135 cases diagnosed with AD were included in the study. Statistical analysis was performed using SPSS v20 for determining the frequency and testing the hypotheses, for p < 0.05, by t tests and One-Way ANOVA.

Results. Of the 135 cases, 51.9% were male children and 48.1% female children aged 1 month to 127 months with a mean of 26.21. According to total serum IgE level, 64.4% of patients had elevated IgE levels, 35.6% normal levels. According to the SCORAD, children had mild AD in 20.7% of cases, moderate in 70.4%, and severe in 8.9%. IgA deficiency was found for 48.1% of cases, and for 51.9% normal. IgG deficiency was found in 38.5% of cases. The independent samples t tests showed statistical significant demonstrating correlations between IgE level and IgA immune deficiency, between SCORAD and IgG and IgA immune deficiency. Atopic march is influenced by elevated IgE, IgA and IgG immune deficiency, p <0.05.

Conclusions. Atopy in AD can be influenced by complex factors, both internal and environmental, but this remains a controversial topic. External factors acting on a background genetically predisposed to atopy trigger the manifestation of AD.

Keywords: atopic dermatitis, immune dysfunction, IgA, IgG, IgE

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Sempronia Ecaterina Coclici

Scleroderma in young children

Revista Romana de PEDIATRIE | Volumul LX, Nr. 2, An 2011

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Ileana Ioniuc, Stela Gotia, Evelina Moraru, Aurica Rugina, Alina Murgu and Monica Alexoae

ABSTRACT

Chronic disease of unknown etiology, scleroderma represents a disease that occurs rarely in young children, with an estimated frequency of less than 1% up to age 5. Evolution of scleroderma is variable, unpredictable and the delineation of clinical forms in children is difficult. Some patients may experience periods of calm for many years, others have a progressive worsening, without remission and death. Our case is characterized by the onset at a young age, bringing together major and minor criteria for systemic scleroderma.

Key words: systemic scleroderma, young children

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Ileana Ioniuc

SCLERODERMIA LA COPILUL MIC

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Ileana Ioniuc, Stela Gotia, Evelina Moraru, Aurica Rugina, Alina Murgu and Monica Alexoae

REZUMAT

Boală cronică de etiologie necunoscută, sclerodermia este o boală care apare rar la copilul mic, estimându-se o frecvenţă de sub 1% până la vârsta de 5 ani. Evoluţia cazurilor de sclerodermie este variabilă, imprevizibilă, delimitarea formelor clinice fiind dificilă la copil. Unii bolnavi pot prezenta perioade de acalmie mai mulţi ani, alţii au o evoluţie progresivă spre agravare (fără remisiuni) şi deces. Cazul prezentat se particularizează prin debutul sclerodermiei la vârstă mică, bolnavul întrunind, la 1 an si 3 luni, criterii majore şi minore de sclerodermie sistemică.

Cuvinte cheie: sclerodermie sistemică, copil mic

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Ileana Ioniuc

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