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Sempronia Ecaterina Coclici

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Articole semnate de acelasi autor in Revista Romana de Pediatrie:

DERMATITA ATOPICA – DISFUNCTIA IMUNA ASOCIATA ATOPIEI

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Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 4, An 2015
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

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DERMATITA ATOPICA – DISFUNCTIA IMUNA ASOCIATA ATOPIEI

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REZUMAT

Sistemul imunitar joacă un rol complex în apărarea organismului ca răspuns la „non-self“, răspunde anormal la antigenii alergeni (hipersensibilitate şi autoimunitate) şi este caracterizat prin toleranţă imună cu lipsa de reactivitate la propriile structuri (auto).

Scop. Scopul acestui studiu este de a demonstra că, în dermatita atopică, deficitul imun influenţează dezvoltarea atopiei, severitatea bolii şi dezvoltarea de comorbidităţi.

Material şi metode. În urma analizei foilor de observaţie, 135 de cazuri diagnosticate cu AD au fost incluse în studiu. Analiza statistică a fost realizată cu ajutorul SPSS V20 pentru determinarea frecvenţei şi testarea ipotezelor, pentru p <0,05, prin testele T şi OneWay ANOVA.

Rezultate. Din cele 135 de cazuri, 51,9% au fost copii de sex masculin şi 48,1% de copii de sex feminin, cu vârsta cuprinsă între 1 lună şi 127 luni, cu o medie de 26,21. Potrivit IgE serice totale, 64,4% dintre pacienţi au avut niveluri ridicate de IgE, 35,6% niveluri normale. În conformitate cu SCORAD, copiii au avut forma uşoară în 20,7% din cazuri, forma moderată în 70,4%, iar severă în 8,9% din cazuri. Deficitul de IgA a fost găsit în 48,1% din cazuri, iar deficitul de IgG a fost găsit în 38,5% din cazuri. Testele t de corelaţie pe eşantioane independente constată valori semnificative statistic între nivelul IgE şi deficitul de IgA, între SCORAD şi deficitul de IgG şi IgA. Marşul atopic este influenţat de valorile crescute ale IgE şi deficitul de IgA pentru un p<0,05.

Concluzii. Atopia în DA poate fi influenţată de factori complecşi, atât interni, cât şi de mediu, dar acest lucru rămâne un subiect controversat. Factorii externi care acţionează pe un fundal genetic predispus la atopie poate declanşa manifestarea DA.

Cuvinte cheie: dermatită atopică, deficit imun, IgE, IgA, IgG

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ATOPIC DERMATITIS – ASSOCIATED IMMUNE DYSFUNCTION

SELECT ISSUE

Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 4, An 2015
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

ATOPIC DERMATITIS – ASSOCIATED IMMUNE DYSFUNCTION

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ABSTRACT

The immune system shows a complex role to defend the body in response to “non-self” antigens, respond abnormally to antigens allergens (hypersensitivity and autoimmunity) and shows immune tolerance by lack of reactivity to its own structures (self).

Aim. The aim of this study is to demonstrate that in atopic dermatitis immune deficiency influences the development of atopy, disease severity and comorbidities.

Material and methods. Following medical record review, 135 cases diagnosed with AD were included in the study. Statistical analysis was performed using SPSS v20 for determining the frequency and testing the hypotheses, for p < 0.05, by t tests and One-Way ANOVA.

Results. Of the 135 cases, 51.9% were male children and 48.1% female children aged 1 month to 127 months with a mean of 26.21. According to total serum IgE level, 64.4% of patients had elevated IgE levels, 35.6% normal levels. According to the SCORAD, children had mild AD in 20.7% of cases, moderate in 70.4%, and severe in 8.9%. IgA deficiency was found for 48.1% of cases, and for 51.9% normal. IgG deficiency was found in 38.5% of cases. The independent samples t tests showed statistical significant demonstrating correlations between IgE level and IgA immune deficiency, between SCORAD and IgG and IgA immune deficiency. Atopic march is influenced by elevated IgE, IgA and IgG immune deficiency, p <0.05.

Conclusions. Atopy in AD can be influenced by complex factors, both internal and environmental, but this remains a controversial topic. External factors acting on a background genetically predisposed to atopy trigger the manifestation of AD.

Keywords: atopic dermatitis, immune dysfunction, IgA, IgG, IgE

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