Liliana Profir

Latest posts by Liliana Profir (see all)

Specific serum IgE – marker for atopic sensitization and allergy in children. Case study - 28/07/2015
IGE SPECIFICE SERICE – MARKERI AI SENSIBILIZARII ATOPICE SI ALERGIEI LA COPIL. STUDIU CAZUISTIC - 28/07/2015
Clinical and evolutive aspects in IgE-mediated food allergy in infants and small children - 22/07/2015

Articole semnate de acelasi autor in Revista Romana de Pediatrie:

Specific serum IgE – marker for atopic sensitization and allergy in children. Case study

Revista Romana de PEDIATRIE | Volumul LXI, Nr. 3, An 2012

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Stela Gotia, Monica Alexoae, Ileana Ioniuc, Alina Murgu, Mihai Colţa, Liliana Profir and Aurica Rugina

ABSTRACT

Specific serum IgE elevated levels integrated in anamnesis and clinical context, make the diagnosis more precise and suggest the severity of the allergic diseases. Knowing the allergen could be predictive and is essential for the secondary prevention measures. Objective: determination of serum specific IgE in children of different ages with clinical manifestations of allergy, to assess the spectrum of allergens incriminated and their correlation with clinical diagnosis. Methods: retrospective study, 30 months (2007-2009) on 423 children diagnosed based on international criteria with different allergic diseases. Serum specific IgE was performed by a immunecromathographical quantitative assay QuantiScan. Results: Serum specific IgE values were positive in 71,39% cases (302 children) from all 423 children included in the study, more frequently in children under 6 years of age (61,25%). Polysensitizations were more frequently, especially to respiratory allergens, 66 children over 6 years (21,85%) and 43 young children (14,23%) and monosensitizations under 6 years old (Dermatophagoides 6,25% , cow’s milk - 5,62%). Respiratory allergy (bronchial asthma+/- allergic rhinitis) was correlated with polysensitizations, including also food allergens – 67%, more frequently in children over 6 years old. Atopic dermatitis was correlated mainly with food allergy (48%) in children under 3 years old. Incriminated allergens ( in order of frequency): cow’s milk, dermatophagoides, egg white, peanuts - under 6 years; dust, pollens, animal epithelia, peanuts – over 6 years old. Conclusions: specific serum IgE confirm the clinical diagnosis in most cases. Polysensitizations were detected in patients with systemic allergy symptoms. The allergens spectrum is characterised by the high frequency of polysensitizations and respiratory allergens sensitizations in young children.

Key words: specific IgE, allergy diseases, children

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Stela Gotia

IGE SPECIFICE SERICE – MARKERI AI SENSIBILIZARII ATOPICE SI ALERGIEI LA COPIL. STUDIU CAZUISTIC

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Stela Gotia, Monica Alexoae, Ileana Ioniuc, Alina Murgu, Mihai Colţa, Liliana Profir and Aurica Rugina

REZUMAT

Valorile crescute ale IgE serice specifice diferiţilor alergeni, integrate în contextul anamnestic şi clinic, aduc un plus de precizie diagnosticului şi sugerează severitatea bolilor alergice. Cunoaşterea alergenului poate avea valori predictive şi este esenţială pentru măsurile de profilaxie secundară. Obiectiv. Determinarea IgE serice specifice la copii de diferite vârste cu manifestări clinice de alergie, în vederea evaluării spectrului de alergeni incriminaţi şi corelarea lor cu diagnosticul clinic. Material şi metodă. Studiu retrospectiv, pe o perioadă de 30 luni (2007-2009) a 423 de bolnavi, diagnosticaţi cu diferite boli alergice, conform criteriilor recunoscute de forurile internaţionale. Dozarea IgE specifice s-a realizat printr-o metodă cantitativă imunocromatografi că - QuantiScan. Rezultate. Valorile IgE serice specifice au fost pozitive în 71,39% cazuri (302 copii) din totalul de 423 copii luaţi în studiu, mai frecvent la copiii sub 6 ani (61,25%). Polisensibilizările au fost mult mai des întâlnite, mai frecvent la aeroelergeni, 66 copii peste 6 ani (21,85%) şi 43 copii mici (14,23%), iar monosensibilizarea a fost mai frecventă la grupa de vârstă sub 6 ani (Dermatophagoides 6,25% şi lapte 5,62%). Alergia respiratorie (AB+/- RA) s-a corelat cu polisensibilizarea, inclusiv la alergeni alimentari – 67%, mai frecvent la grupa de vârstă peste 6 ani, iar dermatita atopică s-a corelat in principal cu alergia alimentară (48%) la grupa de vârstă sub 3 ani. Alergenii incriminaţi (în ordinea frecvenţei): sub 6 ani – lapte, dermatophagoides, albuş, alune; peste 6 ani – praf, polen, epitelii de animale, alune. Concluzii. IgE specific seric a confirmat diagosticul clinic în majoritatea cazurilor. Polisensibilizările s-au înregistrat cu precădere la bolnavi cu manifestări alergice de tip sistemic. Profilul sensibilizărilor din zona noastră geografică, determinat prin IgE specifice serice, se particularizează prin frecvenţa crescută a polisensibilizărilor şi prin implicarea aeroalergenilor la vârsta mică.

Cuvinte cheie: IgE specifice, boli alergice, copii

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Stela Gotia

Clinical and evolutive aspects in IgE-mediated food allergy in infants and small children

Revista Romana de PEDIATRIE | Volumul LXII, Nr. 3, An 2013

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Monica Alexoae, Evelina Moraru, Aurica Rugina, Alina Murgu, Ileana Ioniuc, Liliana Profir and Stela Gotia

ABSTRACT

The skin, respiratory and gastrointestinal allergy manifestations can evolves alternatively or concomitant in the first years of life; food sensitization is the common etiology. The objective of this study is the assessment of IgE-mediated food allergy regarding clinical manifestations and their correlation with risk factors, the dietary and drug therapy impact during a 22 months monitoring. Results. The onset food allergy manifestations (mean age 5-11 months) involve skin (66 cases), respiratory (55 cases) and/or gastrointestinal tract (5 cases). We evidenced respiratory aeroallergens sensitization (bronchial asthma and/or allergic rhinitis) in 50 percents of cases. 43 children achieved oral tolerance for one or more foodS, most commonly in milk and egg white allergy. Conclusions. The secondary and tertiary food allergy prevention measures are not allways be able to prevent the progression of atopic march to polisensitizations and complex clinical manifestations.

Key words: evolution, small child, food allergy

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Monica Alexoae

ASPECTE CLINICO-EVOLUTIVE SUB TRATAMENT IN ALERGIA ALIMENTARA IgE-MEDIATA LA SUGAR SI COPILUL MIC

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Monica Alexoae, Evelina Moraru, Aurica Rugina, Alina Murgu, Ileana Ioniuc, Liliana Profir and Stela Gotia

REZUMAT

Manifestările alergice cutanate, respiratorii şi/sau digestive din primii ani de viaţă pot evolua eşalonat, concomitent sau alternativ, sensibilizarea alimentară fiind cauza cea mai frecventă.

Obiectivul studiului a fost evaluarea alergiei alimentare IgE mediate la sugar şi copilul mic privind formele şi gravitatea manifestărilor clinice în corelaţie cu factorii de risc şi impactul prognostic al măsurilor dietetice şi medicamentoase evaluat în dinamică, individualizat după o dispensarizare medie de 22 de luni.

Rezultate. Debutul real al alergiei alimentare a fost precoce (5-11 luni) prin manifestări cutanate (66 cazuri), respiratorii (55 cazuri) şi/sau digestive (5 cazuri). Apariţia manifestărilor respiratorii (astm bronşic şi/sau rinită alergică) prin sensibilizare la aeroalergeni a fost surprinsă în 50% din cazuri. Toleranţa orală pentru unul sau mai multe alimente s-a instalat la 43 copii, mai frecvent pentru lapte şi albuş de ou.

Concluzie. Măsurile de profilaxie secundară şi terţiară aplicate susţinut la copiii cu manifestări alergice corelate cu sensibilizarea alimentară nu împiedică evoluţia spre polisensibilizări şi manifestări clinice complexe în toate cazurile

Cuvinte cheie: evoluţie, copil mic, alergie alimentară

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Monica Alexoae

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Liliana Profir

Latest posts by Liliana Profir (see all)

Articole semnate de acelasi autor in Revista Romana de Pediatrie:

Specific serum IgE – marker for atopic sensitization and allergy in children. Case study

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