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O. Brumariu

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Articole semnate de acelasi autor in Revista Romana de Pediatrie:

Mycofenolate mofetil versus cyclophosphamide for steroid-resistant nephrotic syndrome in children

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Revista Romana de PEDIATRIE | Volumul LX, Nr. 2, An 2011
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

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Mycofenolate mofetil versus cyclophosphamide for steroid-resistant nephrotic syndrome in children

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ABSTRACT

The management of patients with steroid-resistant nephrotic syndrome is difficult. We report our experience on treatment with Mycophenolate mofetil versus Cyclophosphamide, in a retrospective analysis of 54 cases of idiopathic steroid-resistant nephrotic syndrome with different histological aspects. The complete and sustained remission rate was 50% for Mycophenolate, which confirm the efficacy of treatment, higher than with Cyclophosphamide (39.53%).

Key words: nephrotic syndrome, mycophenolate mofetil, cyclophosphamide, steroid-resistancy

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MYCOFENOLATUL DE MOFETIL VERSUS CICLOFOSFAMIDA IN SINDROMUL NEFROTIC CORTICOREZISTENT LA COPII

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Revista Romana de PEDIATRIE | Volumul LX, Nr. 2, An 2011
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

MYCOFENOLATUL DE MOFETIL VERSUS CICLOFOSFAMIDA IN SINDROMUL NEFROTIC CORTICOREZISTENT LA COPII

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REZUMAT

Managementul pacienţilor cu sindrom nefrotic corticorezistent (SNCR) este dificil. Vom prezenta experienţa noastrǎ în tratamentul cu Mycofenolat de mofetil versus Ciclofosfamidǎ, într-o analizǎ retrospectivǎ a 54 de cazuri cu sindrom nefrotic corticoresistent idiopatic cu aspecte histologice diferite. Rata remisiunii complete şi susţinute a fost de 50% pentru Mycofenolat, ceea ce confirmǎ eficienţa tratamentului, aceastǎ ratǎ fiind mai mare decât în tratamentul cu Ciclofosfamidǎ (39,53%).

Cuvinte cheie: sindrom nefrotic, mycofenolat de mofetil, ciclofosfamidă, corticorezistenţǎ

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Upper digestive tract manifestations inCRF patients on dialysis

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Revista Romana de PEDIATRIE | Volumul LXI, Nr. 2, An 2012
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Upper digestive tract manifestations inCRF patients on dialysis

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REZUMAT

Background: CRF patients are prone to a wide range of complications: gastroesophageal reflux disease, esophagitis, gastropathy, gastritis and duodenitis, gastric and duodenal ulcer, angiodysplasia.

Objectives: the study’s aim was to highlight the gastro-duodenal symptoms, the frequency of pathological modifi cations of eso-gastro-duodenal mucous membrane and the presence of H.pylori in CRF children receiving dialysis.

Material and methods: the study included 55 children admitted to the IVth Pediatric Nephrology Clinic of the Emergency Clinical Hospital “Sf Maria” Iasi, all receiving dialysis, to which was applied a systematized protocol: objective and subjective symptoms and the results of upper gastrointestinal endoscopy. The study included patients with mucosal changes detected endoscopically.

Conclusions: Pathological modifications of the upper digestive tract mucous membrane in children on chronic dialysis are inconstant, suggesting the need for endoscopy in each case. H.pylori was found in 24/55 (43.63%) biopsies and points out the relatively frequent association between gastro-duodenal lesions and H.pylori in chronic dialysis patient.

Key words: esophagitis, gastritis, H.pylori, dialysis

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MANIFESTARILE TUBULUI DIGESTIV SUPERIOR LA PACIENTUL CU IRC DIALIZAT

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Revista Romana de PEDIATRIE | Volumul LXI, Nr. 2, An 2012
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

MANIFESTARILE TUBULUI DIGESTIV SUPERIOR LA PACIENTUL CU IRC DIALIZAT

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REZUMAT

Introducere: bolnavii cu IRC sunt susceptibili la o gamă largă de complicaţii: reflux gastro-esofagian, esofagită, gastropatie, gastrită şi duodenită, ulcer gastric şi duodenal, angiodisplazie. Obiective: studiul a constat în evidenţierea simptomelor gastro-duodenale, a frecvenţei modificărilor patologice ale mucoasei eso-gastro-duodenale şi a prezenţei H.pylori la copiii cu IRC aflaţi în program de dializă. Material şi metodă: lotul de studiu a fost format din 55 de copii internaţi în Clinica a IV-a Nefrologie, aflaţi în program de substituţie renală cronică, la care s-a aplicat un protocol ce a sistematizat: simptomele obiective şi subiective şi rezultatele endoscopiei digestive superioare. Lotul cuprinde bolnavii cu modificări ale mucoasei depistate endoscopic. Concluzii: modificările patologice ale mucoasei eso-gastro-duodenale la copilul dializat cronic se reflectă clinic inconstant, ceea ce sugerează necesitatea endoscopiei pentru fiecare caz. Prezenţa H.pylori la 24/55 (43,63%) cazuri biopsiate evidenţiază asocierea relativ frecventă între leziunile gastro-duodenale şi H.pylori la pacienţii dializaţi cronic.

Cuvinte cheie: esofagită, gastrită, H.pylori, dializǎ

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