Mycofenolate mofetil versus cyclophosphamide for steroid-resistant nephrotic syndrome in children

Revista Romana de PEDIATRIE | Volumul LX, Nr. 2, An 2011

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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Florentina Cucer, Ingrith Miron, Mihaela Munteanu, Codruţa Iliescu Haliţchi, R. Muller, R. Russu, Anca Ivanov, Doina Mihaila and O. Brumariu

ABSTRACT

The management of patients with steroid-resistant nephrotic syndrome is difficult. We report our experience on treatment with Mycophenolate mofetil versus Cyclophosphamide, in a retrospective analysis of 54 cases of idiopathic steroid-resistant nephrotic syndrome with different histological aspects. The complete and sustained remission rate was 50% for Mycophenolate, which confirm the efficacy of treatment, higher than with Cyclophosphamide (39.53%).

Key words: nephrotic syndrome, mycophenolate mofetil, cyclophosphamide, steroid-resistancy

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