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Laura Mihaela Trandafir

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Articole semnate de acelasi autor in Revista Romana de Pediatrie:

OSTEO-ARTICULAR DISORDER IN CHILDREN WITH CYSTIC FIBROSIS

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Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 4, An 2015
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

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OSTEO-ARTICULAR DISORDER IN CHILDREN WITH CYSTIC FIBROSIS

, , , , , and

ABSTRACT

Osteo-articular disorder in cystic fibrosis is considered a common complication of this pathology. The most efficient strategies used for bone health maintenance in patients with cystic fibrosis are early recognition, prevention and correct treatment. The purpose of this study was the clinical and paraclinical evaluation of patients hospitalized in the 3rd Clinic of Pediatrics, “Sf. Maria” Children’s Emergency Hospital Iasi, diagnosed with cystic fibrosis that exhibited also symptoms of osteo-articular manifestation. The results from this study support the idea that the association of treatment, calcium, multimineral supplements with appropriate hygienic-dietary regimen and with the background therapy of the disease can contribute significantly to better healthand wellbeing. Also, non-compliance to treatment among patients and their families significantly contributes to early installation of the complications, including the osteo-articular ones (even from the age of 6 years).

Keywords: cystic fibrosis, osteo-articular complication, child

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AFECTAREA OSTEOARTICULARA IN FIBROZA CHISTICA LA COPIL

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Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 4, An 2015
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

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AFECTAREA OSTEOARTICULARA IN FIBROZA CHISTICA LA COPIL

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ABSTRACT

Afectarea osteoarticulară din fibroza chistică (FC) este considerată o complicaţie comună a acestei patologii. Prevenţia, recunoaşterea precoce şi tratamentul corect efectuat reprezintă strategiile cele mai eficiente pentru susţinerea sănătăţii osoase la bolnavii cu fibroză chistică. Scopul prezentului studiu a fost reprezentat de evaluarea clinico-paraclinică a bolnavilor diagnosticaţi cu FC aflaţi în evidenţa Clinicii III Pediatrie din cadrul Spitalului Clinic de Urgenţă pentru Copii „Sf. Maria“ Iaşi care prezentau şi simptome de afectare osteoarticulară. Rezultatele studiului au condus la concluzia că tratamentul cu vitamina D, calciu şi suplimente cu multiminerale asociat cu regim igieno-dietetic corespunzător şi cu tratamentul de fond al maladiei poate contribui semnificativ la îmbunătăţirea stării de sănătate, determinând şi ameliorarea calităţii vieţii. Totodată, lipsa complianţei la tratament a pacienţilor sau familiilor acestora contribuie semnificativ la instalarea precoce a complicaţiilor, inclusiv a celor osteoarticulare (chiar de la vârsta de 6 ani).

Cuvinte cheie: fibroză chistică, afectare osteoarticulară, copil

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OSTEO-ARTICULAR DISORDER IN CHILDREN WITH CYSTIC FIBROSIS

SELECT ISSUE

Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 4, An 2015
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

OSTEO-ARTICULAR DISORDER IN CHILDREN WITH CYSTIC FIBROSIS

, , , , , and

ABSTRACT

Osteo-articular disorder in cystic fibrosis is considered a common complication of this pathology. The most efficient strategies used for bone health maintenance in patients with cystic fibrosis are early recognition, prevention and correct treatment. The purpose of this study was the clinical and paraclinical evaluation of patients hospitalized in the 3rd Clinic of Pediatrics, “Sf. Maria” Children’s Emergency Hospital Iasi, diagnosed with cystic fibrosis that exhibited also symptoms of osteo-articular manifestation. The results from this study support the idea that the association of treatment, calcium, multimineral supplements with appropriate hygienic-dietary regimen and with the background therapy of the disease can contribute significantly to better healthand wellbeing. Also, non-compliance to treatment among patients and their families significantly contributes to early installation of the complications, including the osteo-articular ones (even from the age of 6 years).

Keywords: cystic fibrosis, osteo-articular complication, child

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POLIMORFISMUL MANIFESTARILOR CLINICE IN BOALA CELIACA LA COPIL

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Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 4, An 2015
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

POLIMORFISMUL MANIFESTARILOR CLINICE IN BOALA CELIACA LA COPIL

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REZUMAT

Boala celiacă (BC) reprezintă o afecţiune sistemică autoimună produsă prin sensibilizarea la gluten la pacienţii cu predispoziţie genetică. Manifestările clinice ale BC sunt extrem de variate, de la sindromul tipic de malabsorbţie intestinală (caracterizat prin diaree cronică, meteorism abdominal şi malnutriţie) la simptome atipice care pot afecta orice sistem sau organ: constipaţie cronică, hepatocitoliză persistentă, anemie refractară la tratamentul cu fier, dureri abdominale recurente, afecţiuni neurologice, defect al smalţului dentar. Autorii prezintă patru pacienţi de vârstă pediatrică diagnosticaţi cu diferite forme atipice de boală celiacă: forma cu dureri abdominale recurente, cu sindrom de hepatocitoliză şi formă cu constipaţie cronică, toate însoţite de falimentul creşterii şi un caz de diabet zaharat tip I asociat cu boală celiacă. În concluzie, este necesară cunoaşterea tuturor formelor clinice ale bolii celiace de către medicul pediatru, gastroenterolog şi medicul de familie pentru a diagnostica boala la vârsta copilăriei şi, astfel, să prevină complicaţiile pe termen lung, respectiv osteoporoza, infertilitatea si limfomul intestinal.

Cuvinte cheie: boală celiacă, manifestări clinice, diabet zaharat tip I, copil

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POLYMORPHISM OF THE CLINICAL SIGNS OF CELIAC DISEASE IN CHILDREN

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Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 4, An 2015
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
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DOAJ
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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

POLYMORPHISM OF THE CLINICAL SIGNS OF CELIAC DISEASE IN CHILDREN

, , , and

ABSTRACT

Celiac disease (CD) is an autoimmune systemic condition caused by sensitivity to gluten in genetically predisposed patients. The clinical signs of CD are extremely diverse, ranging from the typical intestinal malabsorption syndrome (characterized by chronic diarrhea, abdominal distension and malnutrition) to atypical symptoms that may involve any system or organ: chronic constipation, increased level of liver enzymes, iron deficiency anemia, recurrent abdominal pain, neurological conditions, tooth enamel erosion. The authors report four pediatric cases diagnosed with various atypical forms of celiac disease: the form associated with recurrent abdominal pain and increased level of liver enzymes, and the form associated with chronic constipation, all accompanied by failure to thrive and one case of type I diabetes mellitus associated with celiac disease. To conclude with, pediatricians, gastroenterologists and general practitioners should be familiar with all the clinical forms of coeliac disease in order to be able to diagnose this childhood disease and thus prevent long-term complications like osteoporosis, infertility and intestinal lymphoma.

Keywords: celiac disease, clinical signs, type I diabetes mellitus, child

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SEMNIFICATIA SINDROMULUI DE CITOLIZA LA COPIL – STUDIU CAZUISTIC

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Revista Romana de PEDIATRIE | Volumul LXII, Nr. 4, An 2013
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

SEMNIFICATIA SINDROMULUI DE CITOLIZA LA COPIL – STUDIU CAZUISTIC

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REZUMAT

Determinarea valorilor transaminazelor face parte din protocolul de investigaţii biochimice de rutină care se efectuează la copil, indiferent de simptomatologia clinică. Transaminazele (TGP, TGO) sunt markeri ai leziunilor tisulare care se modifică atât în afecţiuni hepatice, cât şi extrahepatice. Scopul acestui studiu a fost de a stabili etiologia şi semnificaţia clinică a sindromului de citoliză hepatică fără colestază la copiii internaţi pentru diverse afecţiuni pediatrice. Lotul de studiu a cuprins 394 de copiii (cu vârsta cuprinsă între 1,5 luni şi 16 ani) la care au fost decelate valori crescute ale transaminazelor. Protocolul de investigaţii a cuprins anamneza, examenul fizic, investigaţiile biologice complete, markerii virali şi ecografia hepatică.În funcţie de valoarea transaminazelor faţă de valoarea normală (VN), pacienţii au fost incluşi în trei loturi de studiu: 222 pacienţi cu creşteri uşoare ale TGP, TGO (< 2xVN) (lotul I), 164 pacienţi cu TGP, TGO între 2-3xVN (lotul II) şi 8 pacienţi cu TGP, TGO > 3xVN (lotul III). Valoarea transaminazelor a fost determinată lunar în primele 3 luni, iar ulterior, la interval de 2 până la 6 luni din momentul identificării hepatocitolizei. În toate loturile etiologia sindromului de citoliză a fost dominate de afecţiunile acute bacteriene (respiratorii, urinare, digestive) şi virale (infecţia cu virus Epstein Barr, Cito megalovirus). Alte cauze ale sindromului de citoliză au fost bolile nutriţionale şi de metabolism (obezitatea, diabetul zaharat, fenilcetonuria, fibroza chistică, hipotiroidismul congenital). În 20,31% dintre cazuri etiologia nu a fost elucidată, dar valoarea transaminazelor la 6 luni s-a normalizat ca urmare a dietei şi hepatoprotectoarelor. Creşterile uşoare ale valorii TGP, TGO nu necesită învestigaţii laborioase, ele normalizându-se în primele trei luni. Creşterile medii şi severe, persistente după trei luni de tratament, impun continuarea investigaţiilor pentru stabilirea etiologiei (infecţii virale, boli autoimune, nutriţionale şi de metabolism).

Cuvinte cheie: transaminaze, sindrom de citoliză, copil

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THE SIGNIFICANCE OF CYTOLYSIS SYNDROME IN CHILDREN

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Revista Romana de PEDIATRIE | Volumul LXII, Nr. 4, An 2013
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

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THE SIGNIFICANCE OF CYTOLYSIS SYNDROME IN CHILDREN

, , , and

ABSTRACT

The measurement of aminotransferases levels has become part of the routine biochemical tests done in children regardless of their clinical symptoms. Aminotransferases (ALT, AST) are tissue necrosis markers which change in both hepatic and extra-hepatic conditions. The aim of this study was to establish the etiology and clinical significance of the cytolysis syndrome without cholestasis in children hospitalized for various pediatric conditions. The study group consisted of 394 children (aged between 1.5 months and 16 years)with elevated values of ALT, AST. The investigation protocol applied included history, full physical examination, complete biological investigations, viral markers and liver ultrasounds.Depending on the aminotransferases values as compared to the normal value (NV), the patients were included in 3 study subgroups: 222 patients with slightlyelevated transaminases values (< 2xNV) (subgroup I), 164 patients with ALT and AST values between 2-3xNV (subgroup II) and 8 patients with TGP, TGO values > 3 x NV (subgroup III). The ALT and AST values were determined monthly during the first 3 months, and then every 2 to 6 months. In all groups the etiology was dominated by acute bacterial (respiratory, urinary, digestive) and viral (Epstein Barr, Citomegalovirus infection) conditions. Other causes of cytolysis syndrome were nutritional and metabolic diseases (obesity, mellitus diabetes, phenylketonuria, cystic fibrosis, congenital hypotiroidism). The etiology remained unclear in 20.31% of the cases, yet the transaminase values returned to normal after 6 months with diet and hepatoprotective therapy. Slightly elevated ALT andASTvalues do not require thorough investigations, as they usually return to normal within the first three months. On the other hand, mildly and severe increases, which persist after three months therapy require further investigation to determine the etiology (viral infections, autoimmune, nutritional and metabolic diseases).

Key words: aminotransferases, cytolysis syndrome, child

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AFECTAREA HEPATICA LA COPIII CU FIBROZA CHISTICA

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Revista Romana de PEDIATRIE | Volumul LXIII, Nr. 1, An 2014
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

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AFECTAREA HEPATICA LA COPIII CU FIBROZA CHISTICA

, , and

REZUMAT

Afectarea hepatică reprezintă o manifestare precoce la copiii cu fibroză chistică (FC). Spectrul manifestărilor clinice în afectarea hepato-biliară din FC cuprinde colestaza neonatală, steatoza hepatică, fibroza hepatică, litiaza biliară, ciroza biliară focală şi ciroza multilobulară, cu sau fără hipertensiune portală. Modificarea testelor de evaluare a funcţiei hepatice este inconstantă şi nu se corelează cu severitatea leziunilor hepatice. Diagnosticarea bolii hepatice în FC necesită prezenţa a cel puţin două din cele patru criterii de diagnostic: manifestări clinice, modificarea testelor funcţionale hepatice, ecografice şi anatomopatologice. Screeningul anual pentru suferinţa hepatică este recomandat pentru diagnosticarea bolii asimptomatice şi iniţierea precoce a tratamentului cu acid ursodeoxicholic. Ameliorarea funcţiei hepatice influenţează calitatea vieţii şi creşte rata supravieţuirii la pacienţii cu FC.

Cuvinte cheie: fibroză chistică, afectare hepatică, acid ursodeoxicholic, copil

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LIVER DISEASE IN CHILDREN WITH CYSTIC FIBROSIS

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Revista Romana de PEDIATRIE | Volumul LXIII, Nr. 1, An 2014
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

LIVER DISEASE IN CHILDREN WITH CYSTIC FIBROSIS

, , and

ABSTRACT

Liver disease is an early complication in children with cystic fibrosis (CF).The clinical manifestations in hepatobiliary disease of CF include neonatal cholestasis, liver steatosis, liver fibrosis, biliary lithiasis, focal biliary cirrhosis and multilobular cirrhosis, with or without portal hypertension. Changes in the tests evaluating the liver function are inconsistent and are not correlated with the severity of the liver lesions. The diagnosis of liver disease in CF requires the presence of at least two of the following four diagnosis criteria:clinical manifestations, pathologic liver function tests, ultrasound and histologic changes.The annual follow-up to evaluate the liver function is s recommended for diagnosis of asymptomatic liver disease and early initiation of treatment with ursodeoxycholic acid. The improvement of the liver function influences life quality and increases the survival rate in patients with CF

Keywords: cystic fibrosis, liver disease, ursodeoxycholic acid, children

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DIABETUL ZAHARAT DIN FIBROZA CHISTICA (MUCOVISCIDOZA)

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Revista Romana de PEDIATRIE | Volumul LXIII, Nr. 1, An 2014
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

DIABETUL ZAHARAT DIN FIBROZA CHISTICA (MUCOVISCIDOZA)

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REZUMAT

Diabetul asociat fibrozei chistice este o entitate distinctă comparativ cu diabetul zaharat tip 1 şi 2, dar care are şi simptome caracteristice acestora. Odata cu prelungirea speranţei de viaţa, şi prevalenţa diabetului a crescut, asociindu-se cu un declin mai sever al funcţiei pulmonare şi cu stare nutriţională mai precară comparativ cu ale pacienţilor cu fibroză chistică, dar fără diabet. Autorii prezintă date actuale cu privire la prevalenţa şi fiziopatologia bolii, tabloul clinic, examenele utile în stabilirea diagnosticului, posibilităţile terapeutice şi prognosticul bolii. Concluzionăm că diagnosticarea precoce şi intervenţiile terapeutice adecvate pot diminua impactul negativ al diabetului asupra funcţiei pulmonare şi satusului nutriţional în FC.

Cuvinte cheie: fibroza chistica, diabet zaharat, copil

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