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Dyslipidemia and inflammatory adipokines in a group of children with altered nutritional status
Background. Obesity associates multiple complications, as consequence of chronic inflammation and insulinresistance, changes induced by adipocytes products.
Aim. Determination of serum-levels of inflammation adipokines in obese children and assessment of their relationship with anthropometric and biochemical parameters.
Methods. prospective study including 110 obese children assessed between 1 October 2010-1 March 2013.We determined the leptin levels, adiponectin, interleukins (IL6-8), looking for their correlations with anthropometric and metabolic parameters.
Results. Leptin was 16.79±1.39ng/ml in obese, higher than in control-group (2.78 ± 0.43 ng/ml), while adiponectin was 14871.07 ± 713.17 ng/ml in controls and 9883.49 ± 562.54 ng/ml in obese, with statistically significant differences (p < 0.0001 for both). IL6 and IL8 were also higher in obese group. There were significant correlations between the adipokines and anthropometric indices. Dyslipidemia was found in 20% of obese, 8.18% with increased LDLCholesterol, 26.36% hypertriglyceridemia and 9.09% low HDL-Cholesterol.
Conclusions. inflammatory adipokines are elevated in obese children, correlated with dyslipidemia, and adiponectin decreases, suggesting that marked adiposity in children also can play a role in the pathogenesis of complications.
Key words: adipokines, child, dyslipidemia, obesity, nutritional status