National Awards “Science and Research”
NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.
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Experimental evidence on the beneficial effect of early treatment with etanercept in juvenile idiophatic arthritis
Elena Simona Tucaliuc, Ionela Lăcrămioara Şerban, Cristina Oprişa, Loredana Hurjui, M.M. Hogaş, D. Tucaliuc, D.N. Şerban and Stela Gotia
Systemic inflammatory status is involved in early vascular lesions. Adjuvant-induced arthritis in rats is a commonly used experimental model of arthritis due to common features with rheumatoid arthritis in humans.
Aim: The aim of this study was to determine endothelio-dependent relaxation impairment generated by use of immunomodulatory therapy, etanercept.
Material and method: We used male, adult Wistar rats weighing 250-300 g. Arthritis was induced by a single intradermal injection of 0,1 ml complet Freund adjuvant into the plantar surface of the right hind-foot. Arthritis severity was quantified by pletismometry method. Etanercept therapy was performed twice a week, starting on day 22 post-adjuvant injection for 21 days. Vascular reactivity was performed on popliteal artery. After preconstriction with phenylephrine, we determined the vasodilatory response to acetylcholine.
Results: Acetylcholine-induced vasodilation in popliteal artery rings was significantly impaired in adjuvantinduced arthrits rats, compared to control rats. Etanercept reduces endothelial dysfunction in adjuvantinduced athritis rats.
Conclusions: Inflammatory status causes significant endothelial dysfunction in adjuvant-induced arthritis rats. Imunomodulatory therapy with etanercept significantly improves endothelial dysfunction.
Key words: endothelial dysfunction, adjuvant-induced arthritis, etanercept, rat