Indexed in / abstracted by
Stimati cititori, va reamintim ca autorii primi ai articolelor stiintifice pot acumula 80 de credite EMC in urma publicarii. Daca un articol are mai multi autori, cele 80 de credite [...]
Incepand cu 2016, Societatea Romana de Pediatrie ofera Premiul Societatii - pentru autorii celor mai bune articole stiintifice publicate [...]
Tema plagiatului este tot mai mult discutata in ultima vreme. Aparitia unor programe performante de cautare si identificare a similitudinilor intre texte [...]
Experimental evidence on the beneficial effect of early treatment with etanercept in juvenile idiophatic arthritis
Systemic inflammatory status is involved in early vascular lesions. Adjuvant-induced arthritis in rats is a commonly used experimental model of arthritis due to common features with rheumatoid arthritis in humans.
Aim: The aim of this study was to determine endothelio-dependent relaxation impairment generated by use of immunomodulatory therapy, etanercept.
Material and method: We used male, adult Wistar rats weighing 250-300 g. Arthritis was induced by a single intradermal injection of 0,1 ml complet Freund adjuvant into the plantar surface of the right hind-foot. Arthritis severity was quantified by pletismometry method. Etanercept therapy was performed twice a week, starting on day 22 post-adjuvant injection for 21 days. Vascular reactivity was performed on popliteal artery. After preconstriction with phenylephrine, we determined the vasodilatory response to acetylcholine.
Results: Acetylcholine-induced vasodilation in popliteal artery rings was significantly impaired in adjuvantinduced arthrits rats, compared to control rats. Etanercept reduces endothelial dysfunction in adjuvantinduced athritis rats.
Conclusions: Inflammatory status causes significant endothelial dysfunction in adjuvant-induced arthritis rats. Imunomodulatory therapy with etanercept significantly improves endothelial dysfunction.
Key words: endothelial dysfunction, adjuvant-induced arthritis, etanercept, rat