Indexată BDI | IDB Indexed
Stimați cititori, vă reamintim că autorii primi ai articolelor științifice pot acumula 80 de credite EMC în urma publicării. Dacă un articol are mai mulți autori, cele 80 de credite [...]
RJP și SRPed oferă anual Premiul Național pentru Știință și Cercetare - pentru autorii celor mai bune articole științifice publicate [...]
Tema plagiatului este tot mai mult discutată în ultima vreme. Apariția unor programe performante de căutare și identificare a similitudinilor între texte [...]
Experimental evidence on the beneficial effect of early treatment with etanercept in juvenile idiophatic arthritis
Systemic inflammatory status is involved in early vascular lesions. Adjuvant-induced arthritis in rats is a commonly used experimental model of arthritis due to common features with rheumatoid arthritis in humans.
Aim: The aim of this study was to determine endothelio-dependent relaxation impairment generated by use of immunomodulatory therapy, etanercept.
Material and method: We used male, adult Wistar rats weighing 250-300 g. Arthritis was induced by a single intradermal injection of 0,1 ml complet Freund adjuvant into the plantar surface of the right hind-foot. Arthritis severity was quantified by pletismometry method. Etanercept therapy was performed twice a week, starting on day 22 post-adjuvant injection for 21 days. Vascular reactivity was performed on popliteal artery. After preconstriction with phenylephrine, we determined the vasodilatory response to acetylcholine.
Results: Acetylcholine-induced vasodilation in popliteal artery rings was significantly impaired in adjuvantinduced arthrits rats, compared to control rats. Etanercept reduces endothelial dysfunction in adjuvantinduced athritis rats.
Conclusions: Inflammatory status causes significant endothelial dysfunction in adjuvant-induced arthritis rats. Imunomodulatory therapy with etanercept significantly improves endothelial dysfunction.
Key words: endothelial dysfunction, adjuvant-induced arthritis, etanercept, rat