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Experimental evidence on the beneficial effect of early treatment with etanercept in juvenile idiophatic arthritis
Systemic inflammatory status is involved in early vascular lesions. Adjuvant-induced arthritis in rats is a commonly used experimental model of arthritis due to common features with rheumatoid arthritis in humans.
Aim: The aim of this study was to determine endothelio-dependent relaxation impairment generated by use of immunomodulatory therapy, etanercept.
Material and method: We used male, adult Wistar rats weighing 250-300 g. Arthritis was induced by a single intradermal injection of 0,1 ml complet Freund adjuvant into the plantar surface of the right hind-foot. Arthritis severity was quantified by pletismometry method. Etanercept therapy was performed twice a week, starting on day 22 post-adjuvant injection for 21 days. Vascular reactivity was performed on popliteal artery. After preconstriction with phenylephrine, we determined the vasodilatory response to acetylcholine.
Results: Acetylcholine-induced vasodilation in popliteal artery rings was significantly impaired in adjuvantinduced arthrits rats, compared to control rats. Etanercept reduces endothelial dysfunction in adjuvantinduced athritis rats.
Conclusions: Inflammatory status causes significant endothelial dysfunction in adjuvant-induced arthritis rats. Imunomodulatory therapy with etanercept significantly improves endothelial dysfunction.
Key words: endothelial dysfunction, adjuvant-induced arthritis, etanercept, rat