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Gabriela Doros

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Articole semnate de acelasi autor in Revista Romana de Pediatrie:

INDICELE INTIMA MEDIE CAROTIDIAN LA COPIII OBEZI NASCUTI CU GREUTATE MICA PENTRU VARSTA GESTATIONALA VERSUS CEI NASCUTI CU GREUTATE NORMALA PENTRU VARSTA GESTATIONALA

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Revista Romana de PEDIATRIE | Volumul LXIII, Nr. 3, An 2014
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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INDICELE INTIMA MEDIE CAROTIDIAN LA COPIII OBEZI NASCUTI CU GREUTATE MICA PENTRU VARSTA GESTATIONALA VERSUS CEI NASCUTI CU GREUTATE NORMALA PENTRU VARSTA GESTATIONALA

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REZUMAT

Indicele intimă medie carotidian (IMc) este un cunoscut marker subclinic pentru ateroscleroză. Fenomenul de recuperare nutriţională la copiii născuţi mici pentru vârsta gestaţională (SGA) a fost asociat cu obezitate precoce şi cu riscul dezvoltării sindromului metabolic.

Scop. De a determina dacă există o asociere între SGA şi IMc; de a stabili valori prag ale IMc la copiii obezi.

Material şi metodă. Studiul prospectiv a fost derulat pe o perioadă de un an (iulie 2012 – iunie 2013). Au fost analizaţi 122 de pacienţi cu obezitate, 96 de pacienţi născuţi cu greutate normală pentru naştere (AGA) şi 26 de pacienţi născuţi cu greutate mică pentru naştere (SGA). Ambele loturi au fost omogene din punct de vedere al vârstei, sexului şi indicelui de masă corporală (IMC). Folosind curba ROC au fost stabilite valori prag pentru ambele grupe. IMc a fost semnificativ mai crescut la lotul SGA (p = 0,0035). Valoarea prag de 0,049 cm pentru IMc a fost obţinută la ambele loturi, cumulat, cu o specificitate şi sensibilitate crescută.

Concluzii. Copiii născuţi SGA se asociază cu risc aterosclerotic. IMc este un cunoscut marker subclinic pentru ateroscleroză, fiind o metodă ieftină şi noninvazivă. Studii populaţionale extinse sunt necesare în vederea stabilirii unor valori prag în ceea ce priveşte IMc.

Cuvinte cheie: obezitate, mic pentru vârsta gestaţională, indicele intimă medie carotidian

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COMMON CAROTID INTIMA MEDIA THICKNESS IN OBESE CHILDREN BORN SMALL FOR GESTATIONAL AGE VERSUS APPROPRIATE FOR GESTATIONAL AGE

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Revista Romana de PEDIATRIE | Volumul LXIII, Nr. 3, An 2014
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
NLM Catalog
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

COMMON CAROTID INTIMA MEDIA THICKNESS IN OBESE CHILDREN BORN SMALL FOR GESTATIONAL AGE VERSUS APPROPRIATE FOR GESTATIONAL AGE

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ABSTRACT

The intima media thickness of the common carotid artery (CIMT) is a well-known marker of subclinical atherosclerosis. The “catch-up growth” phenomenon in children born small for gestational age (SGA) has been linked to early onset obesity with the subsequent emergence of metabolic syndrome (MetS). Aim: to determine the association between being born SGA and CIMT, a measure of atherogenesis and to establish cut off values for CIMT in obese children.

Material and methods. A prospective study was carried out over a 1 year period (Jul 2012-June 2013). We analyzed 122 obese patients, 96 patients appropriate for gestational age (AGA) and 26 patients SGA. Both groups were matched for age, sex and BMI. CIMT was measured in all the patients. Using ROC curve, cut off values have been obtained for both groups.

Results. CIMT in obese children born SGA was significantly increased as compared with obese children born AGA similar age, sex and BMI (p = 0.0035). A CIMT cut off value of 0.049 cm has been obtained with a high sensitivity and specificity.

Conclusion. Being born SGA increases the atherogenic risk. CIMT is a well-known marker of subclinical atherosclerosis and is a noninvasive and inexpensive method for detecting development of subclinical atherosclerosis. Further population studies regarding reference values for CIMT in obese children born SGA and AGA are necessary

Keywords: small for gestational age, obesity, intima media thickness of the common carotid artery

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