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Adriana Mocanu

Latest posts by Adriana Mocanu (see all)

  • ETIOPATOGENIA MULTIFACTORIALA A PURPUREI HENOCH-SCHONLEIN LA VARSTA PEDIATRICA - 21/07/2015
  • MULTIFACTORIAL ETIOPATHOGENY OF HENÖCH-SCHÖNLEIN PURPURA IN PEDIATRIC AGE - 21/07/2015

Articole semnate de acelasi autor in Revista Romana de Pediatrie:

ETIOPATOGENIA MULTIFACTORIALA A PURPUREI HENOCH-SCHONLEIN LA VARSTA PEDIATRICA

SELECT ISSUE

Revista Romana de PEDIATRIE | Volumul LXIII, Nr. 1, An 2014
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

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Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

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ETIOPATOGENIA MULTIFACTORIALA A PURPUREI HENOCH-SCHONLEIN LA VARSTA PEDIATRICA

Adriana Mocanu, Ingrith Miron, Smaranda Diaconescu, Nicoleta Gimiga, Claudia Olaru and Marin Burlea

ABSTRACT

Purpura Henöch-Schönlein (PHS) este o afecţiune a vaselor mici caracterizată printr-un răspuns anormal al sistemului imun: imunoglobulina A (IgA), fracţiunea a 3-a a complementului şi depunerea de complexe imune circulante în pereţii arteriolelor, venulelor şi a capilarelor. Sunt afectaţi predominant copiii, dar simptomatologia poate apărea şi la vârsta adultă. Boala este mai frecventă la pacienţii de sex masculin. Etiologia purpurei nu este deocamdată cunoscută, însă se pare ca există anumiţi factori de risc pentru apariţia acesteia: agenţi infecţioşi (Streptococ, parvovirusuri), înţepături de insecte, alimente sau medicamente (antibiotice, antihistaminice). Sus ceptibilitatea la PHS poate avea origine genetică. Numeroase rapoarte sugerează că deficienţa complementului (C4) datorată deleţiei genelor ce codează sinteza acestei fracţiuni determină predispoziţia la nefropatie IgA şi la nefrita Henöch-Schönlein.

Keywords: purpura Henöch Schönlein, vasculită, copil

Full text | PDF

Adriana Mocanu

MULTIFACTORIAL ETIOPATHOGENY OF HENÖCH-SCHÖNLEIN PURPURA IN PEDIATRIC AGE

SELECT ISSUE

Revista Romana de PEDIATRIE | Volumul LXIII, Nr. 1, An 2014
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

MULTIFACTORIAL ETIOPATHOGENY OF HENÖCH-SCHÖNLEIN PURPURA IN PEDIATRIC AGE

Adriana Mocanu, Ingrith Miron, Smaranda Diaconescu, Nicoleta Gimiga, Claudia Olaru and Marin Burlea

ABSTRACT

Henöch-Schönlein purpura is a small-vessel vasculitis characterized by an abnormal response of the immune system: immunoglobulin A (IgA), C3 and immune complex deposition in arterioles, capillaries and venules. The syndrome is mostly seen in children, but it may affect people of any age. It is more common in boys than in girls. The etiology of Henöch-Schönlein purpura is unknown. Multiple infectious agents as well as drugs, foods, and insect bites may trigger Henöch-Schönlein purpura. Susceptibility to HSP may have a genetic origin. Several reports suggest that deficiency of complement 4 (C4) from deletion of C4 genes predisposes patients to IgA nephropathy and HSP nephritis.

Keywords: Henöch-Schönlein purpura, vasculitis, child

Full text | PDF

Adriana Mocanu


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