MULTIFACTORIAL ETIOPATHOGENY OF HENÖCH-SCHÖNLEIN PURPURA IN PEDIATRIC AGE

Revista Romana de PEDIATRIE | Volumul LXIII, Nr. 1, An 2014

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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Adriana Mocanu, Ingrith Miron, Smaranda Diaconescu, Nicoleta Gimiga, Claudia Olaru and Marin Burlea

ABSTRACT

Henöch-Schönlein purpura is a small-vessel vasculitis characterized by an abnormal response of the immune system: immunoglobulin A (IgA), C3 and immune complex deposition in arterioles, capillaries and venules. The syndrome is mostly seen in children, but it may affect people of any age. It is more common in boys than in girls. The etiology of Henöch-Schönlein purpura is unknown. Multiple infectious agents as well as drugs, foods, and insect bites may trigger Henöch-Schönlein purpura. Susceptibility to HSP may have a genetic origin. Several reports suggest that deficiency of complement 4 (C4) from deletion of C4 genes predisposes patients to IgA nephropathy and HSP nephritis.

Keywords: Henöch-Schönlein purpura, vasculitis, child

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