Sorin Buzinschi

Latest posts by Sorin Buzinschi (see all)

DE CE ESTE EPIGENETICA IMPORTANTA PENTRU PEDIATRIE? - 03/11/2016
WHY IS EPIGENETICS IMPORTANT IN PAEDIATRICS? - 02/11/2016
New benchmarks in the study of biological effects of vitamin D - 31/07/2015

Articole semnate de acelasi autor in Revista Romana de Pediatrie:

DE CE ESTE EPIGENETICA IMPORTANTA PENTRU PEDIATRIE?

Revista Romana de PEDIATRIE | Volumul LXV, Nr. 3, An 2016

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Sorin Buzinschi

REZUMAT

Înţelegerea schimbărilor de patologie din ultimele decade a devenit posibilă datorită achiziţiilor epigenetice. Această ramură a geneticii explică cum influenţează mediul funcţionarea dinamică a genelor. Variaţiile epigenetice sunt determinate de nutriţie, infecţii, noxe chimice, stres. Programarea metabolică iniţiată din viaţa fetală este determinantă pentru patologia cronică a vârstei adulte. Infecţiile, bolile alergice, afecţiunile maligne, prezintă o semnificativă dimensiune epigenetică. Medicul pediatru, acţionând la începutul ciclului de viaţă, poate interveni în derularea acestor procese prin abordarea profilactică şi prin terapia epigenetică, ultima fiind în curs de cristalizare.

Cuvinte cheie: pediatrie, epigenetică, programare, terapie

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Sorin Buzinschi

WHY IS EPIGENETICS IMPORTANT IN PAEDIATRICS?

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Sorin Buzinschi

ABSTRACT

The understanding of the pathological changes in the last decades has become possible due to the epigenetic achievements. This branch of genetics explains the way in which the environment influences the dynamic functioning of genes. The epigenetic variations are determined by nutrition, infections, chemical noxae, and stress. The metabolic programming initiated in the fetal life is decisive in chronic pathology of the adulthood. Infections, allergic diseases, malignant diseases display a significant epigenetic dimension. By acting at the beginning of the life cycle, the paediatrician can intervene in the development of these processes through prophylactic approach and epigenetic therapy, the latter being underway.

Keywords: paediatrics, epigenetics, programming, therapy

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Sorin Buzinschi

New benchmarks in the study of biological effects of vitamin D

Revista Romana de PEDIATRIE | Volumul LX, Nr. 4, An 2011

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Sorin Buzinschi

ABSTRACT

Recent dosage of vitamin D for clinical usage had changed completely the understanding of pathology including its deficit. It was seen that insufficient/deficit of vitamin D are encountered in the population of developed countries and surprisingly in population that live in warm climate. Only a level of the blood levels of vitamin D may be linked to seasonality, latitude or oral intake. The genetic factors may manifest in all its metabolism process. The genes that infl uence the vitamin D level are DHCR7, CYP27A1, CYP2R1 and VDR, CYP24A1 and Gc gene. There are presented the steps of vitamin D metabolism as well as the intervention of different genes in the individual network. Through its autocrine function vitamin D facilitates the expression of genes in cell function its action being pleitropic. There are also listed some of the other disorders apart of rickets that are inluenced by the low level of vitamin D.

Key words: vitamin D, genes, low level, rickets, chronic disease

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Sorin Buzinschi

NOI REPERE IN STUDIUL EFECTELOR BIOLOGICE ALE VITAMINEI D

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

ICMJE- Recommendations

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Sorin Buzinschi

REZUMAT

Dozarea recentă a vitaminei D pentru utilizarea clinică a schimbat complet înţelegerea patologiei sale. S-a constatat că insuficienţa/deficitul de vitamina D este larg întâlnit în populaţia ţărilor dezvoltate şi, surprinzător, în populaţia care trăieşte în climatul cald. Numai o parte a nivelului sanguin al vitaminei D poate fi legat de sezon, latitudine sau aportul oral. Factorii genetici sunt implicaţi în toate etapele metabolismului său. Genele care influenţează nivelul vitaminei D sunt DHCR7, CYP27A1, CYP2R1, gena VDR, CYP24A1 şi gena Gc. Sunt prezentate etapele metabolismului vitaminei D, ca şi intervenţia diferitelor gene implicate. Este discutată funcţia autocrină a vitaminei D, care facilitează expresia pleiotropică a unor gene legate de funcţionarea celulară. Sunt trecute în revistă şi unele dintre tulburările legate de nivelul scăzut al vitaminei D, în afară de rahitism.

Cuvinte cheie: vitamina D, nivel scăzut, rahitism, boli cronice

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Sorin Buzinschi

Prevention of vitamin D deficiency in infants and children

Revista Romana de PEDIATRIE | Volumul LXI, Nr. 1, An 2012

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

ICMJE- Recommendations

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Promoting Global Health

Sorin Buzinschi

ABSTRACT

Reshaping the knowledge of physiological blood levels of vitamin D have strongly brought in actuality the following data: natural nutrition is a vitamin D defi cient factor, children with natural skin pigmentation require more vitamin D, way/limits of solar exposure and the importance of genetic factors in vitamin’s D homeostasis.

Key words: vitamin D, natural alimentation, ultraviolet radiation, doses

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Sorin Buzinschi

PREVENTIA DEFICITULUI DE VITAMINA D LA SUGARI SI COPII

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

ICMJE- Recommendations

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Promoting Global Health

Sorin Buzinschi

REZUMAT

Remodelarea cunoştinţelor privind nivelurile sanguine fiziologice ale vitaminei D au adus în actualitate următoarele date: alimentaţia naturală este un factor de carenţă în vitamina D; copiii cu pigmentare naturală a pielei necesită mai multă vitamina D; deşi sursa principală de vitamina D o constituie radiaţia solară, este necesară restricţia expunerii; factorii genetici influenţează homeostazia 25(OH)D pe termen lung.

Cuvinte cheie: vitamina D, alimentaţie naturală, radiaţia ultravioletă, doze

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Sorin Buzinschi

FACTORI GENETICI IN SEPSISUL COPILULUI

Revista Romana de PEDIATRIE | Volumul LXII, Nr. 4, An 2013

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Sorin Buzinschi

REZUMAT

Amprenta genetică deţine o pondere importantă în apariţia, evoluţia şi prognosticul infecţiilor. Sunt prezentate polimorfismele pentru un singur nucleotid (SNPs) al genelor care codează proteinele cu rol principal în recunoaşterea patogenilor (Toll-like receptors: TLR2, TLR4, TLR5) sau în răspunsul inflamator (TNFα, IL6, IL10) şi care determină gravitatea şi tipurile de infecţii. Configuraţia alelică reprezintă un element important de risc pentru corioamniotită, prematuritate, sepsis şi deces, dar poate fi un factor de creştere a rezistenţei la infecţii comune. Imunodepresia postseptică influenţează decesul tardiv al copiilor care au suferit de şoc infecţios.

Cuvinte cheie: polimorfism genetic, infecţii, risc de deces

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Sorin Buzinschi

GENETIC FACTORS OF SEPSIS IN CHILDREN

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Sorin Buzinschi

ABSTRACT

The genetic fingerprint holds a major relevance in the apparition, evolution and prognosis of infections. The paper focuses on polymorphisms for one nucleotide (SNPs) of the genes which encode proteins with the main role in recognizing pathogens (Toll-like receptors: TLR2, TLR4, TLR5) or in the inflammatory response (TNFα, IL6, IL10) and which determine the severity and the type of the infection. The allelic configuration constitutes an important risk element for corioamniotitis, prematurity, sepsis and death. It can also be a growth factor in resistance to common infections. Post-septic immunodepression influences late mortality of children who have suffered from infectious shock.

Key words: genetic polymorphism, infections, death risk

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Sorin Buzinschi

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