National Awards “Science and Research”
NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.
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The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.
GENETIC FACTORS OF SEPSIS IN CHILDREN
The genetic fingerprint holds a major relevance in the apparition, evolution and prognosis of infections. The paper focuses on polymorphisms for one nucleotide (SNPs) of the genes which encode proteins with the main role in recognizing pathogens (Toll-like receptors: TLR2, TLR4, TLR5) or in the inflammatory response (TNFα, IL6, IL10) and which determine the severity and the type of the infection. The allelic configuration constitutes an important risk element for corioamniotitis, prematurity, sepsis and death. It can also be a growth factor in resistance to common infections. Post-septic immunodepression influences late mortality of children who have suffered from infectious shock.
Key words: genetic polymorphism, infections, death risk