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Sandu Gabriel Aprodu

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Articole semnate de acelasi autor in Revista Romana de Pediatrie:

Clinical aspects and course in syndromic omphalocele

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Revista Romana de PEDIATRIE | Volumul LXII, Nr. 2, An 2013
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

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Clinical aspects and course in syndromic omphalocele

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REZUMAT

Objectives. To analyze the risk factors, clinical aspects and malformations associated with omphalocele.

Material and Methods. The study analyzed 105 cases of omphalocele treated in the Surgery Unit of „Sfânta Maria” Emergency Children Hospital over a period of 23 years according to a complex protocol.

Results. The mean age of mothers was 27.0 years, 34.2% of them being primiparas primigravidas and 50.4% multiparas; 22% of mothers were unmarried; the rate of parental alcohol and tobacco consumption was 32%. The educational level of mothers was relatively low, 62% of them living in rural areas. Delivery was by cesarean section in 27.6% of cases, the mean gestational age was 37.1 weeks, mean birth weight 2717.2 grams, M/F ratio 1.38, 26% of pregnancies were unattended, and only 13.3% were diagnosed prenatally. Chromosomal anomalies were confirmed in 27.6% of patients and of the total 105 patients with omphalocele 71.4% had one or more associated congenital anomalies. Overall survival rate was 45.7% and of the 29 patients with chromosomal abnormalities only 5 (17.2%) survived.

Conclusions. The suspicion of a syndromic omphalocele requires the pregnant woman to be closely followed up and further assessed (multiple scans, amniocentesis for fetal karyotyping), an evaluation of the risk factors and informing the parents who may choose to undergo a therapeutic abortion.

Cuvinte cheie: omfalocel, sindrom malformativ, anomalii genetice

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ASPECTE CLINICO-EVOLUTIVE IN CAZUL OMFALOCELULUI SINDROM

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Revista Romana de PEDIATRIE | Volumul LXII, Nr. 2, An 2013
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
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Ebsco Host - Medline
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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

ASPECTE CLINICO-EVOLUTIVE IN CAZUL OMFALOCELULUI SINDROM

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REZUMAT

Obiective. Lucrarea de faţă are ca obiectiv analiza factorilor de risc, a aspectelor clinice şi a malformaţiilor asociate omfalocelului.

Material şi metode. Studiul efectuat analizează 105 cazuri de omfalocel tratate în Clinica de Chirurgie pediatrică a Spitalului de Urgenţe pentru Copii „Sfânta Maria” Iaşi, pe o perioadă de 23 de ani, conform unui protocol complex.

Rezultate. Vârsta medie a mamelor a fost 27,0 ani, 34,2% dintre ele fiind primigeste, primipare şi 50,4% multipare; 22% dintre mame erau necăsătorite; rata consumului de alcool şi tutun de către părinţi a fost 32%. Nivelul educaţional al mamelor a fost relativ scăzut, mediul de provenienţă fiind rural în 62% dintre cazuri. Naşterea a fost efectuată prin intervenţie cezariană la 27,6% dintre cazuri, vârsta gestaţională medie a fost 37,1 săptămâni, greutatea medie la naştere 2717,2 grame, raportul pe sexe 1,38 M/F. 26% din sarcini au fost nesupravegheate şi doar 13,3% au fost diagnosticate antenatal. La 27,6% dintre pacienţi s-au confirmat anomalii cromozomiale, iar din totalul celor 105 pacienţi cu omfalocel 71,4% aveau una sau mai multe anomalii congenitale asociate. Rata supravieţuirii per total a fost 45,7%, iar dintre cei 29 pacienţi cu anomalii cromozomiale doar 5 pacienţi (17,2%) au supravieţuit.

Concluzii. Suspiciunea de omfalocel sindrom impune dispensarizarea şi explorarea gravidei (ecografii repetate, cariotip antenatal prin amniocenteză), evaluarea factorilor de risc şi informarea părinţilor care pot opta pentru avort terapeutic.

Cuvinte cheie: omfalocel, sindrom malformativ, anomalii genetice

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CONSIDERATII CLINICO-EPIDEMIOLOGICE IN LEGATURA CU ULCERUL PRIMAR LA COPIL – STUDIU RETROSPECTIV PE 5 ANI

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Revista Romana de PEDIATRIE | Volumul LXIII, Nr. 3, An 2014
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

CONSIDERATII CLINICO-EPIDEMIOLOGICE IN LEGATURA CU ULCERUL PRIMAR LA COPIL – STUDIU RETROSPECTIV PE 5 ANI

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REZUMAT

Ulcerul peptic primar se menţine frecvent la copiii din ţările în curs de dezvoltare cu o incidenţă crescută a infecţiei cu H.pylori. Autorii au efectuat un studiu retrospectiv pe 84 de copii internaţi în Clinica V-a Pediatrie Gastroenterologie cu diagnosticul de boală ulceroasă între anii 2007-2023. Criteriile de includere în studiu au fost simptomatologia clinică sugestivă şi endoscopia pozitivă. În lotul studiat au existat 79 de copii cu ulcer primar şi 5 copii cu ulcer secundar. Raportând datele la o populaţie pediatrică de 1.400.000 de copii în nordestul României, incidenţa afecţiunii a fost de 5.64/100.000 iar frecvenţa a fost de 2,58% faţă de totalul de 3.052 de endoscopii digestive superioare efectuate în perioada menţionată. Raportul băieţi: fete a fost de 1.46:1 iar 77,41% dintre pacienţi proveneau din mediul urban. Ulcerele au debutat prin sindrom funcţional digestiv în 70,89% dintre cazuri sau printr-o complicaţie în 29,11% dintre cazuri. Prin endoscopie digestivă superioară au fost identifi cate 62 de ulcere duodenale (UD) şi 10 ulcere gastrice (UG). La 7 copii debutul prin perforaţie a permis identifi carea intraoperatorie a leziunilor. În 70,89% dintre cazuri a fost demonstrată prezenţa cu infecţie cu H. pylori. Factorii favorizanţi pentru această boală au fost: dieta necorespunzătoare (63,16%), fumatul (57,89%), consumul de alcool (15,78%), stresul psihologic (27,27%). Am obţinut o corelaţie semnifi cativă între numărul mare de membri ai unei familii (r = 0,63%; p = 0,002), statusul socioeconomic scăzut (r = 0,87, p = 0,0003) şi infecţia cu H.pylori. Tratamentul antibacterian a utilizat tripla terapie standard la 73,33% pacienţi, cvadrupla terapie bazată pe bismut la 16,66% copii şi terapia secvenţială în 10% dintre cazuri. Rata globală de eradicare moderată obţinută (66,66%) poate fi considerată o dovadă indirectă a rezistenţei mari la claritromicină la copiii din România.

Cuvinte cheie: boală ulceroasă primară, copil, H.pylori

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CLINICAL-EPIDEMIOLOGICAL CONSIDERATIONS REGARDING PRIMARY PEPTIC ULCER IN CHILDREN – 5 YEARS RETROSPECTIVE STUDY

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Revista Romana de PEDIATRIE | Volumul LXIII, Nr. 3, An 2014
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

CLINICAL-EPIDEMIOLOGICAL CONSIDERATIONS REGARDING PRIMARY PEPTIC ULCER IN CHILDREN – 5 YEARS RETROSPECTIVE STUDY

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ABSTRACT

Primary peptic ulcer still remains highly quoted in children from developing countries, the infection with H. pylori having a high incidence among this cases. Between 2007 and 2012 a retrospective study was performed, involving 84 children who were hospitalized in our clinic, ulcer disease being the main diagnosis.The study’s inclusion criteria were suggestive clinical symptoms and positive endoscopy. The studied group consisted by 79 children with primary ulcer and 5 with secondary ulcer. Reporting data for 1,400,000 children population in North – Eastern Romania an incidence of 5.64/100.000 of primitive ulcer disease has been found, the frequency being 2.58% compared with the overall 3052 upper digestive endoscopies done in the years mentioned above. Male to female ratio was 1.46:1. 77.41% of the patients originated in urban areas. The onset was by functional digestive syndrome in 70,89% of the cases or by complications in 29.11% of the cases. By upper digestive endoscopy 62 duodenal ulcers (DU) and 10 gastric ulcers (GU) were identifi ed. Perforation allowed intraoperative diagnosis of ulcerative lesions in 7 children. 70.89% were H. pylori infection – related ulcers. The contributing factors for developing this condition were unproper diet (63.16%), smoking (57.89), alcohol consumption (15.78), psychological stress (27.27%). We obtained a signifi cant correlation between the high number of a family members, (r = 0.63%; p = 0.002), the low socio-economical status (r = 0.87, p = 0.0003) and H.pylori infection. We used the standard triple therapy on 73.33% of the patients, the qvadruple therapy, based on bismuth on 16.66% of the children, and the sequential therapy in 10% of the cases. The global eradication rate was 66.66% therefore we considered this as being an indirect proof for the high claritromycine resistance in children from our region.

Keywords: primary ulcer disease, child, H.pylori

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