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Mariana Andreica

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Articole semnate de acelasi autor in Revista Romana de Pediatrie:

Dilated cardiomyopathies in children – evolutive aspects under Carvedilol treatments

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Revista Romana de PEDIATRIE | Volumul LX, Nr. 4, An 2011
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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Dilated cardiomyopathies in children – evolutive aspects under Carvedilol treatments

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REZUMAT

In dilated cardiomyopathies, carvedilol can be a therapeutic resource, but experience with children is limited.

Objectives. The study of the clinical and paraclinical evolution of dilated cardiomyopathies in children, unresponsive to conventional treatment with angiotensin converting enzyme inhibitors, diuretics, digoxin, requiring the association of carvedilol; the study of the pharmacokinetics of carvedilol in children.

Materials and metods. 16 children with severe dilated cardiomyopathy and left ventricular ejection fraction ≤ 31% were clinically evaluated according to the ROSS / NYHA score and echocardiographical. The measurement of carvedilol in human plasma, high performance liquid chromatography associated with mass spectrometry the external standard method, was used for 7 patients.

Results. Of the 16 children with dilated cardiomyopathies treated with carvedilol as adjuvant medication to conventional therapy, 14 evolved towards clinical and echocardiographic improvement and two towards death. Clinically, the children tolerated carvedilol well, the NYHA score improved and the left ventricular ejection fraction increased from 31% to more than 40%. The study of the pharmacokinetics of carvedilol was performed for 7 subjects. It was demonstrated that the absorption rate does not change with the increase of the administered dose. The time to reach peak concentration is identical for all subjects. The mean half-time is 2.88 hours, being much shorter than in adults. The mean residence time of carvedilol in the body varies similarly, 4.28±1.52 hours.

Conclusions. At the pediatric age, dilated cardiomyopathies unresponsive to conventional treatment with angiotensin-converting enzyme inhibitors, diuretics and digoxin benefited from the association of betablocking medication – carvedilol, with the improvement of the NYHA/ROSS score and of the left ventricular ejection fraction. The study of the pharmacokinetics of carvedilol in children evidenced a mean half-time of 2.88 hours and a mean residence time in the body of 4.28±1.52 hours.

Key words: dilated cardiomyopathy, evolution, pharmacokinetics of carvedilol, child

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CARDIOMIOPATIA DILATATIVA LA COPIL – ASPECTE EVOLUTIVE SUB TRATAMENT CU CARVEDILOL

SELECT ISSUE

Revista Romana de PEDIATRIE | Volumul LX, Nr. 4, An 2011
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
NLM Catalog
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

CARDIOMIOPATIA DILATATIVA LA COPIL – ASPECTE EVOLUTIVE SUB TRATAMENT CU CARVEDILOL

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REZUMAT

În cardiomiopatiile dilatative, carvedilolul poate reprezenta o resursă terapeutică, dar experienţa la copil este limitată.

Obiective. Studiul evoluţiei clinice şi ecocardiografice a cardiomiopatiilor dilatative ale copilului neresponsive la tratamentul convenţional cu inhibitori ai enzimei de conversie ai angiotensinei, diuretice, digoxin, care au necesitat asocierea carvedilolului; studiul farmacocineticii carvedilolului la copii.

Material şi metodă. 16 copii cu cardiomiopatie dilatativă severă şi fracţie de ejecţie a ventriculului stâng ≤ 31% au fost evaluaţi clinic prin scor ROSS / NYHA şi ecocardiografic. Măsurarea carvedilolului în plasma umană s-a efectuat la 7 subiecţi, utilizând cromatografia de lichide de înaltă performanţă, asociată cu spectrometria de masă, metoda standardului extern.

Rezultate. Dintre cei 16 copii cu cardiomiopatii dilatative trataţi cu carvedilol ca medicaţie adjuvantă terapiei convenţionale, 14 au evoluat spre ameliorare clinică şi ecocardiografi că şi doi spre deces. Clinic, copiii au tolerat bine carvedilolul, scorul NYHA s-a ameliorat, iar fracţia de ejecţie a ventriculului stâng a crescut de la sub 31%, la peste 40%. Studiul farmacocineticii carvedilolului a dovedit că viteza de absorbţie nu se modifică odată cu creşterea dozei administrate. Timpul de atingere a concentraţiei maxime a fost identic pentru toţi subiecţii. Timpul de înjumătăţire mediu a fost de 2,88 ore, mai mic decât la adulţi. Timpul mediu de rezidenţă al carvedilolului în organism a fost 4,28±1,52 ore.

Concluzii. La vârsta pediatrică, cardiomiopatiile dilatative neresponsive la tratament convenţional cu inhibitori ai enzimei de conversie ai angiotensinei, diuretice, digoxin au beneficiat de adiţionarea carvedilolului, cu ameliorarea scorului NYHA/ROSS şi a fracţiei de ejecţie a ventriculului stâng. Studiul farmacocineticii carvedilolului la copii a evidenţiat timpul de înjumătăţire mediu al carvedilolului de 2,88 ore şi timpul mediu de rezidenţă în organism de 4,28±1,52 ore.

Cuvinte cheie: cardiomiopatie dilatativă, evoluţie, farmacocinetica carvedilolului, copil

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