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Laura Trandafir

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Articole semnate de acelasi autor in Revista Romana de Pediatrie:

Efficacy of Levetiracetam in children with drug resistant partial seizures

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Revista Romana de PEDIATRIE | Volumul LXI, Nr. 1, An 2012
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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Efficacy of Levetiracetam in children with drug resistant partial seizures

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ABSTRACT

Epilepsy is frequently diagnosed in the pediatric age raising numerous issues related to treatment. Levetiracetam (LEV) is an antiepileptic drug (AED) which is approved as a new combination therapy in different types of drug resistant seizures. The purpose of this study was to evaluate the efficacy and safety of LEV in combination with drug resistant therapy in partial epilepsies children. The study group included 63 children diagnosed with various forms of partial epilepsy. All patients received antiepileptic medication in monotherapy or polytherapy without remission of seizures. Levetiracetam has been associated with MAE initial dose of 10 mg/kg/day (two administrations), the dose was increased up to 40 mg/kg/day within 6 weeks. Patients were studied for a further period of six months. Among children who received associated LEV 34 (53.96%) showed a reduction > 50% of seizures, and 21 (33.35%) reduction was <50%. 8 (12.69%) of patients achieved complete control of critical episodes. Side effects recorded during the study were minimal, being represented by fatigue (12 cases), conduct disorder (7 cases), sleepiness at baseline (three cases), decreased appetite (4 cases), and vomiting (2 cases). Levetiracetam combination treatment in children with drug resistant partial epilepsy is effective with complete control or significant reduction in seizure frequency. Clinical response in the group of studied children was favorable especially in patients with partial motor seizures with or without secondary generalization. Levetiracetam was generally well tolerated, side effects occurred in the study being minimal.

Key words: Levetiracetam, child drug resistance, partial seizures

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EFICACITATEA TRATAMENTULUI CU LEVETIRACETAM LA COPIII CU CRIZE EPILEPTICE PARTIALE FARMACOREZISTENTE

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Revista Romana de PEDIATRIE | Volumul LXI, Nr. 1, An 2012
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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DOI - Crossref
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DOAJ
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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

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EFICACITATEA TRATAMENTULUI CU LEVETIRACETAM LA COPIII CU CRIZE EPILEPTICE PARTIALE FARMACOREZISTENTE

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REZUMAT

Epilepsia este frecvent diagnosticată la vârsta pediatrică, ridicând numeroase probleme legate de tratament. Levetiracetamul (LEV) este un medicament antiepileptic (MAE) nou care este aprobat ca tratament de asociere în diferite tipuri de crize epileptice farmacorezistente. Scopul acestui studiu a fost de a evalua eficacitatea şi siguranţa asocierii LEV în tratamentul epilepsiilor parţiale farmacorezistente la copii. Lotul de studiu a cuprins 63 de copii diagnosticaţi cu diferite forme de epilepsie parţială. Toţi pacienţii primeau medicaţie antiepileptică în mono sau politerapie fără remiterea crizelor. Levetiracetamul a fost asociat la MAE iniţială în doză de 10 mg/kg/zi (în două administrări), doză ce a fost crescută până la maxim 40 mg/kg/ zi în decurs de 6 săptămîni. Pacienţii au fost urmăriţi în continuare pe o perioadă de 6 luni. Dintre copiii urmăriţi la care s-a asociat LEV 34 (53,96%) au prezentat o reducere a crizelor cu >50%, iar la 21 (33,35%) reducerea a fost <50%. La 8 (12,69%) dintre pacienţi s-a obţinut controlul complet al episoadelor critice. Efectele secundare înregistrate pe durata studiului au fost minime, fiind reprezentate de fatigabilitate (12 cazuri), tulburări de comportament (7 cazuri), somnolenţă iniţială (3 cazuri), scăderea apetitului (4 cazuri), vărsături (2 cazuri). Asocierea LEV la tratamentul copiilor cu epilepsii parţiale farmacorezistente este eficientă în controlul complet sau în scăderea semnificativă a frecvenţei crizelor. Răspunsul clinic în grupul de copii studiat a fost favorabil în special la pacienţii cu crize parţiale motorii cu sau fără generalizare secundară. Levetiracetamul a fost în general bine tolerat, efectele secundare apărute în studiu fiind minime.

Cuvinte cheie: levetiracetam, crize epileptice parţiale farmacorezistente, copil

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Schönlein-Henoch purpura with neurological manifestations

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Revista Romana de PEDIATRIE | Volumul LXI, Nr. 4, An 2012
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

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ICMJE- Recommendations

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Promoting Global Health

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Schönlein-Henoch purpura with neurological manifestations

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ABSTRACT

Neurological symptoms represent possible manifestations of Schönlein-Henoch purpura. The authors present two children diagnosed with Schönlein-Henoch purpura. In booth cases the onset of disease was with neurological symptoms (epileptic seizures). In booth cases was observed behavioral problems and interictal EEG revealed abnormalities. In one case the neuroimaging exam revealed cerebral ischemic lesions. The authors consider that Schoenlein-Henoch purpura can involve the nervous system and review of the literature indicates that epileptic seizures and behavioral changes are the most frequent neurologic manifestations of this disease, followed by headache, focal neurologic deficits, mononeuropathies and polyradiculoneuropathies

Key words: Schönlein-Henoch purpura, epileptic seizures, behavioral problems

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PURPURA SCHONLEIN-HENOCH CU MANIFESTARI NEUROLOGICE

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Revista Romana de PEDIATRIE | Volumul LXI, Nr. 4, An 2012
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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DOI - Crossref
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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

PURPURA SCHONLEIN-HENOCH CU MANIFESTARI NEUROLOGICE

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REZUMAT

Simptomele neurologice reprezintă manifestări posibile ale purpurei Schönlein-Henoch. Autorii prezintă doi copii diagnosticaţi cu purpură Schönlein-Henoch la care semnele de debut au fost neurologice, fiind reprezentate de crize epileptice. În ambele cazuri s-au asociat tulburări de comportament, iar EEG intercritic a evidenţiat grafoelemente patologice. Într-un caz examenul neuroimagistic cerebral a obiectivat leziuni ischemice cerebrale. Autorii confirmă că purpura Schönlein-Henoch poate interesa sistemul nervos, iar revederea literaturii arată că cele mai frecvente manifestări neurologice ale acestei boli sunt crizele epileptice şi tulburările de comportament, urmate de cefalee, deficite neurologice focale, mononeuropatii şi poliradiculoneuropatii

Cuvinte cheie: purpură Schönlein-Henoch, crize epileptice, tulburări de comportament

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Portal hypertension in children

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Revista Romana de PEDIATRIE | Volumul LXII, Nr. 3, An 2013
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Portal hypertension in children

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ABSTRACT

The diagnosis and medical and surgical therapy of portal hypertension in children have suffered numerous changes over the last decades, being accompanied by an improvement in the prognosis of these patients. The etiology of portal hypertension occurrence has also undergone many changes consisting of an increase in the number of cases of hypertension of hepatic involvement, to the detriment of those with pre-hepatic involvement. This may be account for by higher rates of survival in patients suffering from conditions responsible for the occurrence of hepatic portal vein occlusion (biliary and hepatic atresia in the neonates, etc). An accurate and early diagnosis of these conditions, as well as the proper etiology and portal vein blocking site identification, will allow an accurate medical and/or surgical approach, an increase in the life quality and survival rates of these patients.

Key words: portal hypertension, Budd Chiari syndrome, hypersplenism, portal cavernoma

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HIPERTENSIUNEA PORTALA LA COPIL

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Revista Romana de PEDIATRIE | Volumul LXII, Nr. 3, An 2013
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

HIPERTENSIUNEA PORTALA LA COPIL

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REZUMAT

Diagnosticul şi tratamentul medical şi chirurgical al hipertensiunii portale la copil a cunoscut multiple modificări în ultimele decade, cu o îmbunătăţire în ceea ce priveşte prognosticul acestor pacienţi. De asemenea, etiologia apariţiei hipertensiunii portale a suferit numeroase schimbări prin creşterea proporţiei cazurilor de hipertensiune de cauză hepatică, în detrimentul celor de cauză prehepatică, datorită creşterii supravieţuirii în cazul unor afecţiuni ce sunt responsabile de apariţia obstrucţiei portale hepatice (atrezia de căi biliare, hepatite neonatale etc). Diagnosticul corect şi precoce al acestor situaţii, ca şi identificarea corespunzătoare a etiologiei şi localizării barajului portal vor duce la o abordare medicală şi/sau chirurgicală corectă, cu creşterea calităţii vieţii şi supravieţuirii acestor pacienţi.

Cuvinte cheie: hipertensiune portală, sindrom Budd Chiari, hipersplenism, cavernom portal, ciroză

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COLECISTITA ACUTA ALITIAZICA LA COPIL – PREZENTARE DE CAZ

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Revista Romana de PEDIATRIE | Volumul LXII, Nr. 4, An 2013
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

COLECISTITA ACUTA ALITIAZICA LA COPIL – PREZENTARE DE CAZ

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REZUMAT

Colecistita acută perforată alitiazică, frecventă la adult, este o entitate rar întâlnită la copil. Simptomatologia clinică necaracteristică, aspectele imagistice frecvent neconcludente, fac ca diagnosticul de colecistită acută alitiazică să fie deseori stabilit intraoperator. Această condiţie trebuie totuşi să fie evocată în cadrul diagnosticului diferenţial al unui sindrom peritonitic la copil.

Cuvinte cheie: colecistită acută alitiazică, peritonită

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ACUTE ACALCULOUS CHOLECYSTITIS WITH GALLBLADDER PERFORATION IN CHILDREN – CASE REPORT

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Revista Romana de PEDIATRIE | Volumul LXII, Nr. 4, An 2013
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

ACUTE ACALCULOUS CHOLECYSTITIS WITH GALLBLADDER PERFORATION IN CHILDREN – CASE REPORT

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ABSTRACT

Although relatively common in adult pathology, acute acalculous cholecystitis with gallbladder perforation is a rather infrequent entity in pediatric practice. In many cases, its unspecific clinical symptoms and the often inconclusive medical imagining results lead to the diagnosis of acute acalculous cholecystitis being set intraoperatively. Nevertheless, this condition should be considered when setting the differential diagnosis of a peritonitis syndrome in children.

Key words: acute acalculous cholecystitis, peritonitis

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