Articole semnate de acelasi autor in Revista Romana de Pediatrie:

Inhaled steroids for children: effects on growth

Revista Romana de PEDIATRIE | Volumul LXI, Nr. 2, An 2012

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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Magdalena M. Florea, Stela Gotia and Daniel Boldureanu

ABSTRACT

The effect of long-term use of inhaled corticosteroid (ICS) on growth in asthmatic children and adolescents remain a controversial issue.

Objective: To determine whether inhaled steroid therapy causes delayed linear growth and other anthropometric parameters change (height, weight, body mass index – BMI) in children with asthma in a 2 years survey.

Methods: 76 children (5-18 years old) with mild to severe persistent asthma treated with inhaled coricosteroids alone or in association with long acting beta agonist therapy and other anti-inflammatory therapy (montelukast) in conformity with GINA 2006 guideline was assessed in Department of Clinical Allergology and Immunology “St. Marie” Children Hospital – Iassy. The dynamic relationship between ICS – dose and linear growth was followed. Height/age, weight/age and BMI/age Z scores were calculated every twelve months and the data obtained was compared with those recorded from 75 children – control group.

Results: after 2 years of ICS use in children with asthma we found a decrease in height gain velocity especially in the second year of survey (p=0,012), without any statistical significant impact on weight and BMI. There was no correlation between the level of ICS dose (small, medium or height) and the growth curve in height, weight and BMI.

Conclusions: long-term ICS therapy might affect the linear growth in children with asthma regardless of dose, without a significant impact on weight or BMI.

Key words: asthma, inhaled corticosteroid therapy, velocity of linear growth

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Magdalena M. Florea

IMPACTUL CORTICOTERAPIEI INHALATORII ASUPRA CURBEI DE CRESTERE LA COPIII CU ASTM BRONSIC

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Magdalena M. Florea, Stela Gotia and Daniel Boldureanu

REZUMAT

Impactul corticoterapiei inhalatorii (CSI) asupra curbei de creştere staturo-ponderale pe termen lung la copiii cu astm bronşic rămâne o problemă controversată. Obiectivul studiului a fost de a evalua influenţa CSI administrată pe termen lung (2 ani) asupra parametrilor de creştere (talie, greutate, indice de masă corporală – IMC) la copiii cu astm bronşic.

Metodă: au fost selectaţi pentru studiu 76 de copii (5-18 ani) cu astm persistent uşor – sever care au primit corticoterapie inhalatorie asociat cu bronhodilatator cu durată lungă de acţiune sau/şi montelukast sodic conform GINA 2006. Au fost urmărită în dinamică relaţia doză CSI – curbă de creştere, iar datele obţinute comparate cu cele ale unui lot martor (75 de cazuri) folosind scorul z.

Rezultate: datele obţinute în urma folosirii CSI pe o perioadă de 2 ani la copii astmatici în diferite trepte de severitate indică o încetinire a curbei de creştere statuare mai ales în al doilea an al studiului (p = 0,012), fără a influenţa semnificativ statistic greutatea sau IMC. Nu s-a găsit o corelaţie între doza de CSI administrată (mică, medie, mare) şi curba taliei, a greutăţii şi valoarea IMC.

Concluzii: CSI administrată perioadă lungă de timp ar putea afecta ritmul de creştere statuară la copiii astmatici în orice treaptă de severitate a bolii şi indiferent de doza administrată, fără a afecta semnificativ greutatea sau IMC.

Cuvinte cheie: astm, corticoterapie inhalatorie, curba creşterii statuare

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Magdalena M. Florea