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Codruţa Iliescu Haliţchi

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Articole semnate de acelasi autor in Revista Romana de Pediatrie:

Mycofenolate mofetil versus cyclophosphamide for steroid-resistant nephrotic syndrome in children

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Revista Romana de PEDIATRIE | Volumul LX, Nr. 2, An 2011
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

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Mycofenolate mofetil versus cyclophosphamide for steroid-resistant nephrotic syndrome in children

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ABSTRACT

The management of patients with steroid-resistant nephrotic syndrome is difficult. We report our experience on treatment with Mycophenolate mofetil versus Cyclophosphamide, in a retrospective analysis of 54 cases of idiopathic steroid-resistant nephrotic syndrome with different histological aspects. The complete and sustained remission rate was 50% for Mycophenolate, which confirm the efficacy of treatment, higher than with Cyclophosphamide (39.53%).

Key words: nephrotic syndrome, mycophenolate mofetil, cyclophosphamide, steroid-resistancy

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MYCOFENOLATUL DE MOFETIL VERSUS CICLOFOSFAMIDA IN SINDROMUL NEFROTIC CORTICOREZISTENT LA COPII

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Revista Romana de PEDIATRIE | Volumul LX, Nr. 2, An 2011
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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DOI - Crossref
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DOAJ
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Ebsco Host - Medline
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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

MYCOFENOLATUL DE MOFETIL VERSUS CICLOFOSFAMIDA IN SINDROMUL NEFROTIC CORTICOREZISTENT LA COPII

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REZUMAT

Managementul pacienţilor cu sindrom nefrotic corticorezistent (SNCR) este dificil. Vom prezenta experienţa noastrǎ în tratamentul cu Mycofenolat de mofetil versus Ciclofosfamidǎ, într-o analizǎ retrospectivǎ a 54 de cazuri cu sindrom nefrotic corticoresistent idiopatic cu aspecte histologice diferite. Rata remisiunii complete şi susţinute a fost de 50% pentru Mycofenolat, ceea ce confirmǎ eficienţa tratamentului, aceastǎ ratǎ fiind mai mare decât în tratamentul cu Ciclofosfamidǎ (39,53%).

Cuvinte cheie: sindrom nefrotic, mycofenolat de mofetil, ciclofosfamidă, corticorezistenţǎ

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A prognostic score in Rotavirus gastroenteritis in children

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Revista Romana de PEDIATRIE | Volumul LXII, Nr. 3, An 2013
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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DOI - Crossref
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DOAJ
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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

A prognostic score in Rotavirus gastroenteritis in children

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ABSTRACT

Diarrhea is a major health problem and a common cause of morbidity and mortality in children, Rotavirus being the most frequent cause of infectious diarrhea in infants and young children. Aim. Evaluation of patients diagnosted and treated at Arcadia Hospital with Rotavirus gastroenteritis associated on admission with leukocytosis with polynucleosis, and development of a prognostic score by analyzing the associated clinical and biological changes. Methods. Included in the study were 70 patients diagnosed with Rotavirus diarrheea in which several clinical and biological parameters were analyzed in view of determining the changes occurring in those associating leukocytosis with polynucleosis at onset. By statistical analysis the “profile” of the patient with Rotavirus diarrhea associated with leukocytosis with polynucleosis was outlined. Thus we formulated a porgnostic score classifying Rotavirus gastroenteritis into 3 forms: mild (score < 11), moderate (score = 12-20) and severe (score > 20). Clinical course in patients associating leukocytosis with polynucleosis was considered favorable within approximately 1½-3 days, corresponding to prognostic score 12-20. Conclusions. Leucocytosis with polynucleosis at onset in patients with Rotavirus gastroenteritis is not an indicator of bacterial infection, but a negative prognostic factor. This score is easy to calculate and use in clinical practice in patients with acute Rotavirus diarrheea and allows a rapid formulation of prognosis and estimation of disease progression.

Key words: diarrheea, Rotavirus, child, prognostic score

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UN SCOR PROGNOSTIC UTIL IN GASTROENTERITA ACUTA CU ROTAVIRUS LA COPIL

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Revista Romana de PEDIATRIE | Volumul LXII, Nr. 3, An 2013
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

UN SCOR PROGNOSTIC UTIL IN GASTROENTERITA ACUTA CU ROTAVIRUS LA COPIL

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REZUMAT

Diareea reprezintă o problemă majoră de sănătate şi o cauză comună de morbiditate şi mortalitate la copii, Rotavirusul reprezentând cea mai importantă cauză de diaree infecţioasă la sugar şi copilul mic. Obiectivul lucrării. Evaluarea pacienţilor diagnosticaţi şi spitalizaţi în Arcadia Hospital cu gastroenterită acută cu Rotavirus, care prezentau la internare leucocitoză cu polinucleoză şi elaborarea unui scor prognostic prin analiza modificărilor clinice şi biologice asociate. Material şi metodă. Am urmărit 70 de pacienţi diagnosticaţi cu diaree cu Rotavirus, la care am analizat mai mulţi parametri clinici şi biologici, urmărind modificările la cei care asociau leucocitoză cu polinucleoză la debut. Am conturat cu ajutorul analizei statistice „profilul” pacientului cu diaree cu Rotavirus care asociază leucocitoza cu polinucleoză. Am formulat astfel un scor prognostic care clasifică gastroenterita cu Rotavirus în 3 forme: uşoară (scor prognostic < 11), moderată (scor prognostic = 12-20) şi severă (scor > 20). Evoluţia la pacienţii care asociau leucocitoză cu polinucleoză a fost considerată favorabilă într-un interval de aproximativ 1½-3 zile, corespunzând scorului prognostic cuprins între 12-20. Concluzii. Leucocitoza cu polinucleoză la debut la pacienţii cu gastroenterită cu Rotavirus nu a reprezentat un indicator de infecţie bacteriană, ci un element de prognostic nefavorabil. Scorul prognostic propus este uşor de calculat şi de aplicat în practica medicală la pacienţii cu diaree acută cu Rotavirus şi permite formularea rapidă a prognosticului şi estimarea duratei de evoluţie a bolii.

Cuvinte cheie:  diaree, rotavirus, copil, scor prognostic

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