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Therapy with biological agents in juvenile-onset ankylosing spondylarthritis
Ankylosing spondylarthritis is an immune-mediated inflammatory disease, which includes axial and peripheral arthritis, inflammation of the site where tendons and joint capsules attaches to the bone and degeneration of the sacroiliac joint and the spinal cord joints, leading to progressive spinal fusions. Introduction of new immunomodulatory molecules into therapy aiming at interleukins, such as the tumor necrosis factor alpha, was considered a major breakthrough in the treatment of severe ankylosing spondylarthritis. This case illustrates the particular evolution of the clinical manifestations in correlation with joint trauma, gastrointestinal infection and the devastating consequences of active HLA-B27 positive ankylosing spondylarthritis with juvenile onset.
Key words: spondylarthritis, enthesitis, ankylosing, juvenile, biological agents