National Awards “Science and Research”
NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.
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The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.
The infection – risk factor for asthma in children
According to hygiene theory, the infectious agents gives some protection against asthma by initiating a Th1 type immune defense mechanism. Now this issue is reconsidered, demonstrating that certain viral or bacterial infection occurring mainly in children at risk of personal and / or family atopy can trigger asthma by deviating the immune response towards TH2 line. In the initiation and maintenance of this “switch-up” mechanism are involved a number of factors in relation to bronchial epithelial cell whose action is modulated by genes. The knowledge of these mechanisms opens new therapeutic perspectives in the treatment of asthma in children.
Key words: bronchial asthma, infections, child