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The infection – risk factor for asthma in children
According to hygiene theory, the infectious agents gives some protection against asthma by initiating a Th1 type immune defense mechanism. Now this issue is reconsidered, demonstrating that certain viral or bacterial infection occurring mainly in children at risk of personal and / or family atopy can trigger asthma by deviating the immune response towards TH2 line. In the initiation and maintenance of this “switch-up” mechanism are involved a number of factors in relation to bronchial epithelial cell whose action is modulated by genes. The knowledge of these mechanisms opens new therapeutic perspectives in the treatment of asthma in children.
Key words: bronchial asthma, infections, child