New benchmarks in the study of biological effects of vitamin D

Revista Romana de PEDIATRIE | Volumul LX, Nr. 4, An 2011

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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Sorin Buzinschi

ABSTRACT

Recent dosage of vitamin D for clinical usage had changed completely the understanding of pathology including its deficit. It was seen that insufficient/deficit of vitamin D are encountered in the population of developed countries and surprisingly in population that live in warm climate. Only a level of the blood levels of vitamin D may be linked to seasonality, latitude or oral intake. The genetic factors may manifest in all its metabolism process. The genes that infl uence the vitamin D level are DHCR7, CYP27A1, CYP2R1 and VDR, CYP24A1 and Gc gene. There are presented the steps of vitamin D metabolism as well as the intervention of different genes in the individual network. Through its autocrine function vitamin D facilitates the expression of genes in cell function its action being pleitropic. There are also listed some of the other disorders apart of rickets that are inluenced by the low level of vitamin D.

Key words: vitamin D, genes, low level, rickets, chronic disease

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