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Maria Dorina Craciun

Latest posts by Maria Dorina Craciun (see all)

  • IMPORTANTA DIAGNOSTICULUI ETIOLOGIC IN INFECTIILE VIRALE SEVERE ALE TRACTULUI RESPIRATOR INFERIOR LA SUGAR SI COPIL - 17/07/2015
  • THE IMPORTANCE OF VIRAL ETIOLOGY DETERMINATION IN SEVERE LOWER RESPIRATORY TRACT INFECTIONS IN INFANTS AND CHILDREN - 17/07/2015

Articole semnate de acelasi autor in Revista Romana de Pediatrie:

IMPORTANTA DIAGNOSTICULUI ETIOLOGIC IN INFECTIILE VIRALE SEVERE ALE TRACTULUI RESPIRATOR INFERIOR LA SUGAR SI COPIL

SELECT ISSUE

Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 2, An 2015
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

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Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

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IMPORTANTA DIAGNOSTICULUI ETIOLOGIC IN INFECTIILE VIRALE SEVERE ALE TRACTULUI RESPIRATOR INFERIOR LA SUGAR SI COPIL

Alexandru-Ioan Ulmeanu, Carmen Zapucioiu, Maria Dorina Craciun and Coriolan Ulmeanu

REZUMAT

Introducere. Pneumonia comunitară reprezintă una din cauzele principale de deces în lume la copii cu vârsta sub 5 ani. Detecţia virală prin PCR multiplex este din ce în ce mai utilizată în practică, ea este utilă pentru a înţelege epidemiologia şi impactul virusurilor asupra populaţiei pediatrice însă există în continuare multe discuţii legate de cum influenţează detecţia virală modul efectiv de îngrijire al pacientului.

Obiective. În studiul efectuat ne-am propus analiza impactului pe care l-a avut identificarea etiologiei virale asupra duratei spitalizării şi asupra tratamentului administrat pe parcursul internării în spital.

Material şi metodă. Am efectuat un studiu retrospectiv pe o perioadă de 4 ani, au fost selectaţi copii între 0-5 ani cu infecţie severă de tract respirator inferior. Am comparat 3 grupuri: un grup cu infecţie virală specificată, un grup cu infecţie virală nespecificată şi un grup cu infecţie bacteriană.

Rezultate. În perioada analizată 72 de copii ce au prezentat semne de insuficienţă respiratorie acută au avut stabilit un diagnostic etiologic concret de infecţie virala, doar 2% din totalul infecţiilor virale diagnosticate în spital. Etiologia principală a fost reprezentată de virusul sinciţial respirator (VSR) în 73,5% dintre cazuri, urmat de Influenza cu 11%, Parainfluenza cu 4,2%, Metapneumovirusul (HMPV), Rinovirus, Bocavirus şi Adenovirus toate cu 2,8%. În cadrul infecţiei virale nespecifi cate s-au folosit antibiotice în 85,5% (n = 53) dintre cazuri. În cadrul infecţiei virale specificate deşi etiologia virală a fost certă, rata de folosire a antibioticelor a fost mai ridicată de 92% (n = 57) Durata spitalizării a fost în medie de cu 2,5 zile mai lungă în cadrul lotului cu infecţie virală specificată, faţă de lotul cu infecţie virală nespecifi cată. Deşi diagnosticul de infecţie virală a fost cert, dat fiind tabloul clinic sever şi vârsta mica a copiilor cheltuielile realizate pentru cei cu infecţie virală specificată au fost cu 30% mai mari faţă de cei cu infecţie virală nespecificată.

Concluzii. În studiul efectuat VSR este virusul cel mai frecvent implicat în etiologia ITRI virale, fiind implicat în forme severe de boală mai ales la sugarii mici şi foştii prematuri. Antibioterapia este utilizată în mod frecvent în formele severe de ITRI, chiar dacă etiologia virală este certă şi cunoscută, clasele de antibiotice folosite fiind asemănătoare. Determinarea etiologiei virale nu a redus spitalizarea, şi nici nu a dus la schimbarea atitudinii terapeutice a medicului curant.

Cuvinte cheie: pneumonie, bronşiolită, pneumonie virală, costuri spitalizare, antibioterapie

Full text | PDF

Alexandru-Ioan Ulmeanu

THE IMPORTANCE OF VIRAL ETIOLOGY DETERMINATION IN SEVERE LOWER RESPIRATORY TRACT INFECTIONS IN INFANTS AND CHILDREN

SELECT ISSUE

Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 2, An 2015
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

THE IMPORTANCE OF VIRAL ETIOLOGY DETERMINATION IN SEVERE LOWER RESPIRATORY TRACT INFECTIONS IN INFANTS AND CHILDREN

Alexandru-Ioan Ulmeanu, Carmen Zapucioiu, Maria Dorina Craciun and Coriolan Ulmeanu

ABSTRACT

Introduction. Community-acquired pneumonia is one of the leading causes of death worldwide in children under 5 years. In practice, viral detection using multiplex PCR is becoming increasingly used, it is most useful to understand the epidemiology and impact of viruses on the pediatric population but there are still many debates regarding the influence of viral detection on patient care.

Objectives. In this study we aimed to analyze the impact of viral etiology determination on the duration of hospitalization and on the administered treatment.

Material and methods. The selection criteria was: children between 0-5 years with severe lower respiratory tract infection. We have analyzed three groups of patients: a group with specified viral infection, a second group with unspecified viral infection and a third group with bacterial infection.

Results. In the analyzed period 72 children under 5 years of age who have shown signs of acute respiratory failure have been diagnosed with a specifi c viral infection, only 2% of the total viral infections. The main etiology was represented by respiratory syncytial virus (RSV) in 73.5% of cases, followed by Influenza 11%, Parainfluenza 4.2%, metapneumovirus (hMPV), Rhinovirus, Adenovirus and Bocavirus all with 2.8%. Within the unspecified viral infection group antibiotics were used in 85.5% (n = 53) of the cases. Within the specified viral infection group although viral etiology was firmly established antibiotics usage rate was higher 92% (n = 57). Duration of hospital stay was 2,5 days higher in the viral specified group compared with the unspecified one. Thus we found that although the diagnosis of viral infection was certainly given because of severe clinical picture and young age of children the expenses were 30% higher.

Conclusions. In our study, RSV is the most common virus involved in the etiology of viral LRTI and is encountered in the most severe forms of the disease especially in young infants and prematures. Antibiotics are commonly used in the severe forms of LRTI, even if the viral etiology is certain and the groups of antibiotics used are similar. Determination of viral etiology has not reduced hospitalization, nor has led to changing of physician therapeutic approach.

Keywords: pnemonia, bronchiolitis, viral pneumonia, hospital cost, antibiotics

Full text | PDF

Alexandru-Ioan Ulmeanu


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