Articole semnate de acelasi autor in Revista Romana de Pediatrie:

FENO SI ATOPIA IN ASTMUL BRONSIC LA COPII

Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 2, An 2015

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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Cristiana Stanciulescu, Mirela Chiru, Alina Oprea, Daniela Pacurar, Carmen Zapucioiu, Elena Petrisor and Dumitru Oraseanu

REZUMAT

Obiective. Stabilirea relaţiei între valoarea concentratiei oxidului nitric expirat (FENO) şi atopia în astmul bronşic la copii.

Metode. Au fost examinaţi 92 de pacienţi cu diagnosticul de astm bronşic stabilit, cu vârste cuprinse între 5 şi 18 ani, care s-au prezentat în Clinica de Pediatrie a Spitalului Clinic de Urgenţe pentru Copii „Grigore Alexandrescu“. Terenul atopic a fost evaluat prin date anamnestice, clinice şi investigaţii de laborator (eozinofile serice şi IgE totale). Tuturor pacienţilor li s-a determinat concentraţia oxidului nitric expirat.

Rezultate. S-au obţinut valori crescute ale FENO la copiii cu astm bronşic alergic faţă de cei cu astm bronşic nonalergic, valori care se corelează cu eozinofi lia şi creşterea imunoglobulinelor E totale.

Concluzii. Măsurarea FENO este utilă pentru evaluarea inflamaţiei mucoasei bronşice la copiii cu astm bronşic atopic.

Cuvinte cheie: FENO, eozinofilie, Ig E, astm, atopie

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Cristiana Stanciulescu

FENO AND ATOPY IN PEDIATRIC ASTHMA

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Cristiana Stanciulescu, Mirela Chiru, Alina Oprea, Daniela Pacurar, Carmen Zapucioiu, Elena Petrisor and Dumitru Oraseanu

ABSTRACT

Objectives. The aim of this study was to determine the manner in which the level of exhaled nitric oxide (FENO) influences the atopic status in children with asthma.

Methods. The study included 92 asthmatic children (aged 5-18 years) admitted on the Pediatric Clinic of “Grigore Alexandrescu” Emergency Clinical Hospital for Children. The atopic status was evaluated through anamnesis, clinical examination and laboratory determination of serum eosinophils and total Ig E. All children underwent measurement of FENO.

Results. Children with atopic asthma had higher levels of FENO than children with nonatopic asthma. The FENO values correlate with eosinophilia and high values of immunoglobulin E.

Conclusion. FENO is a useful marker for the evaluation of airway infl ammation in children with atopic asthma.

Keywords: FENO, eosinophilia, IgE, asthma, atopy

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Cristiana Stanciulescu