Indexed in / abstracted by
Stimati cititori, va reamintim ca autorii primi ai articolelor stiintifice pot acumula 80 de credite EMC in urma publicarii. Daca un articol are mai multi autori, cele 80 de credite [...]
Incepand cu 2016, Societatea Romana de Pediatrie ofera Premiul Societatii - pentru autorii celor mai bune articole stiintifice publicate [...]
Tema plagiatului este tot mai mult discutata in ultima vreme. Aparitia unor programe performante de cautare si identificare a similitudinilor intre texte [...]
Malformative syndrome in patients with trisomy 21
Background and aims. Trisomy 21 is the most frequent autosomal chromosomopathy. The clinical picture includes dysmorphism, developmental delay and malformative syndrome. At present time, in Romania, the cytogenetic diagnosis is delayed. The aim of this study was to evaluate the current malformative syndrome and to correlate its elemets and the cytogenetic features.
Material and method. We conducted an observational study that included 136 patients with trisomy 21 recruited from the Department of Medical Genetics, Emergency Children’s Hospital, Cluj-Napoca and the Department of Pediatrics, “Grigore Alexandrescu” Emergency Children’s Hospital, Bucharest. The patients were evaluated recording the associated congenital malformations.
Results. In 91.2% of the cases the diagnosis of regular trisomy 21 was established. The cariogram was performed late, at a mean age of 1 year 6 months. 94.1% associated at least one congenital malformation, 36.8% having four or more. In descending order of the frequency, the following malformations were described: osteo-articular, cutaneous, cardiac, of male genitalia, digestive, reno-urinary, muscular, ocular, respiratory and of the thyroid in: 86%; 66.2%; 52.2%; 21.7%; 18.4%; 8.1%; 8.1%; 7.4%; 2.9% and 1.5% respectively. No significant differences were found between regular and mosaic trisomy 21.
Conclusions. The clinical picture of trisomy 21 is going through some changes lately, regarding the malformative syndrome, the prevalence we communicate for some of the specific congenital malformations is lower; in 5.9% of the cases no congenital malformations were associated. No significant differences were found in relation to the cytogenetic diagnosis.
Key words: trisomy 21, malformative syndrome