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Raluca Maria Vlad

Latest posts by Raluca Maria Vlad (see all)

  • EVALUARE EPIDEMIOLOGICA SI PSIHO-SOCIALA A COPILULUI OBEZ – STUDIU PROSPECTIV - 07/06/2016
  • EPIDEMIOLOGICAL AND PSYCHOSOCIAL ASSESSMENT OF CHILDHOOD OBESITY – PROSPECTIVE STUDY - 07/06/2016
  • Malformative syndrome in patients with trisomy 21 - 27/07/2015

Articole semnate de acelasi autor in Revista Romana de Pediatrie:

EVALUARE EPIDEMIOLOGICA SI PSIHO-SOCIALA A COPILULUI OBEZ – STUDIU PROSPECTIV

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Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 4, An 2015
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

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EVALUARE EPIDEMIOLOGICA SI PSIHO-SOCIALA A COPILULUI OBEZ – STUDIU PROSPECTIV

Oana Elena Iaru, Raluca Maria Vlad, Marina Popov, Roxana Andrei, Irina Dijmarescu, Daniela Pacurar and Dumitru Oraseanu

REZUMAT

Obiectiv. Studiul de faţă şi-a propus evaluarea unor parametri epidemiologici şi psiho-sociali într-un eşantion de copii supraponderali şi obezi spitalizaţi pentru diverse patologii. Durata studiului a fost de 12 luni.

Material şi metodă. S-a efectuat un studiu prospectiv, fiind incluşi 78 de copii (6-18 ani) supraponderali (IMC peste percentila 85) şi obezi (IMC peste percentila 95). Criteriul de excludere din studiu a constat în prezenţa unei patologii corelate cu obezitatea secundară. S-a aplicat un chestionar complex care a cuprins factorii de risc familiali şi personali, evaluarea psihologică şi evaluarea calităţii vieţii conform chestionarului PedsQL. Pentru fiecare pacient s-a efectuat evaluare clinică, a parametrilor de laborator şi imagistică (ecografie abdominală).

Rezultate. Dintre copiii incluşi în studiu, 55 au un părinte supraponderal şi 15 au ambii părinţi cu exces ponderal. Ancheta alimentară a dezvăluit greşeli alimentare în rândul a 65 de pacienţi (83,3%). Timpul mediu zilnic alocat televizorului şi calculatorului este crescut (5,7 ore/zi) comparativ cu timpul alocat activităţii fizice acasă şi la şcoală (0,57 ore/zi).

Concluzii. Obezitatea a fost asociată cu riscul familial, erori în programul şi conţinutul alimentaţiei, timpul scă- zut alocat activităţii fizice şi timpul prelungit petrecut în faţa calculatorului sau televizorului. Aceste repere trebuie avute în vedere în programele profilactice şi curative ale acestei patologii.

Cuvinte cheie: obezitate, populaţie pediatrică, anchetă alimentară, activitate fizică

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Oana Elena Iaru

EPIDEMIOLOGICAL AND PSYCHOSOCIAL ASSESSMENT OF CHILDHOOD OBESITY – PROSPECTIVE STUDY

SELECT ISSUE

Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 4, An 2015
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

EPIDEMIOLOGICAL AND PSYCHOSOCIAL ASSESSMENT OF CHILDHOOD OBESITY – PROSPECTIVE STUDY

Oana Elena Iaru, Raluca Maria Vlad, Marina Popov, Roxana Andrei, Irina Dijmarescu, Daniela Pacurar and Dumitru Oraseanu

ABSTRACT

Objective. The aim of this study was the evaluation of epidemiological and psychosocial parameters in a sample of overweight and obese children hospitalized for various pathologies. The duration of the study was 12 months.

Methods. We performed a prospective study that included overweight and obese children admitted in the Paediatric Unit of our hospital from July 2014 until June 2015. The exclusion criteria consisted of the presence of secondary pathologies related to obesity. A questionnaire was applied to all patients included with questions about family and personal risk factors for obesity; we realised also a psychological evaluation and quality of life assessment (PedsQL). For each patient we performed clinical evaluation, laboratory and imaging investigations (abdominal ultrasound).

Results. The study included 78 patients: 27 overweight (34.6%), 51 obese (65.3%). We studied the family history concerning the weight status: 55 had one obese parent and 15 had both parents with obesity. We identified dietary errors for almost all patients (65 patients = 83.3%). The average number of hours of physical activity was rather low (0.57 hours/day) and the average time spent in front of the TV and computer was increased (5.7 hours/day).

Conclusions. Obesity has been associated with familial background of obesity, dietary errors (both eating schedule and composition), decreased time spent doing physical activity and increased time dedicated to computer and television. These conclusions should be considered in the prophylactic and curative programs done for this pathology. Keywords: obesity, pediatric population, dietary errors, physical activity

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Oana Elena Iaru

Malformative syndrome in patients with trisomy 21

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Revista Romana de PEDIATRIE | Volumul LXI, Nr. 4, An 2012
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
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NLM Catalog
Ebsco Host - Medline
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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Malformative syndrome in patients with trisomy 21

Raluca Maria Vlad, Paula Grigorescu Sido, Simona Bucerzan, Camelia Al-Khzouz, Ioana Naşcu and Eugen Pascal Ciofu

ABSTRACT

Background and aims. Trisomy 21 is the most frequent autosomal chromosomopathy. The clinical picture includes dysmorphism, developmental delay and malformative syndrome. At present time, in Romania, the cytogenetic diagnosis is delayed. The aim of this study was to evaluate the current malformative syndrome and to correlate its elemets and the cytogenetic features.

Material and method. We conducted an observational study that included 136 patients with trisomy 21 recruited from the Department of Medical Genetics, Emergency Children’s Hospital, Cluj-Napoca and the Department of Pediatrics, “Grigore Alexandrescu” Emergency Children’s Hospital, Bucharest. The patients were evaluated recording the associated congenital malformations.

Results. In 91.2% of the cases the diagnosis of regular trisomy 21 was established. The cariogram was performed late, at a mean age of 1 year 6 months. 94.1% associated at least one congenital malformation, 36.8% having four or more. In descending order of the frequency, the following malformations were described: osteo-articular, cutaneous, cardiac, of male genitalia, digestive, reno-urinary, muscular, ocular, respiratory and of the thyroid in: 86%; 66.2%; 52.2%; 21.7%; 18.4%; 8.1%; 8.1%; 7.4%; 2.9% and 1.5% respectively. No significant differences were found between regular and mosaic trisomy 21.

Conclusions. The clinical picture of trisomy 21 is going through some changes lately, regarding the malformative syndrome, the prevalence we communicate for some of the specific congenital malformations is lower; in 5.9% of the cases no congenital malformations were associated. No significant differences were found in relation to the cytogenetic diagnosis.

Key words: trisomy 21, malformative syndrome

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Raluca Maria Vlad

SINDROMUL MALFORMATIV LA PACIENTII CU TRISOMIE 21

SELECT ISSUE

Revista Romana de PEDIATRIE | Volumul LXI, Nr. 4, An 2012
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

SINDROMUL MALFORMATIV LA PACIENTII CU TRISOMIE 21

Raluca Maria Vlad, Paula Grigorescu Sido, Simona Bucerzan, Camelia Al-Khzouz, Ioana Naşcu and Eugen Pascal Ciofu

REZUMAT

Obiective. Trisomia 21 este cea mai frecventă cromozomopatie autozomală. Tabloul clinic cuprinde dismorfism, retard în dezvoltare şi sindrom malformativ. În prezent, în România diagnosticul citogenetic se stabileşte tardiv. Studiul de faţă şi-a propus evaluarea sindromului malformativ actual şi corelarea elementelor acestuia cu modificările citogenetice.

Material şi metodă. Am efectuat un studiu observaţional în care au fost incluşi 136 de pacienţi cu trisomie 21 provenind din Compartimentul Genetică al Spitalului Clinic de Urgenţă pentru Copii, Cluj-Napoca, şi din Clinica Pediatrie a Spitalului Clinic de Urgenţă pentru Copii „Grigore Alexandrescu“, Bucureşti. Pacienţii au fost evaluaţi din punct de vedere al malformaţiilor congenitale asociate.

Rezultate. În 91,2% dintre cazuri s-a stabilit diagnosticul de trisomie 21 omogenă. Cariograma a fost efectuată tardiv, în medie la 1 an 6 luni. 94,1% au asociat cel puţin o malformaţie congenitală, 36,8% numărând patru sau mai multe. Au fost prezente în ordine descrescătoare a frecvenţei următoarele malformaţii: osteoarticulare, tegumentare, cardiace, genitale masculine, digestive, reno-urinare, musculare, oculare, ale aparatului respirator si tiroidiene la: 86%; 66,2%; 52,2%; 21,7%; 18,4%; 8,1%; 8,1%; 7,4%; 2,9% şi respectiv 1,5%. Nu s-au evidenţiat diferenţe semnificative între pacienţii cu trisomie 21 omogenă şi cei cu mozaicism.

Concluzii. Tabloul clinic la pacienţii cu trisomie 21 a suferit modificări în ceea ce priveşte sindromul malformativ, prevalenţa constatată a unora dintre malformaţiile considerate specifice fiind mai mică sau malformaţiile lipsind la 5,9% dintre pacienţi. Nu au existat diferenţe în funcţie de modificările citogenetice constatate.

Cuvinte cheie: trisomia 21, sindrom malformativ

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Raluca Maria Vlad

Hematological changes in patients with trisomy 21

SELECT ISSUE

Revista Romana de PEDIATRIE | Volumul LXII, Nr. 2, An 2013
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Hematological changes in patients with trisomy 21

Raluca Maria Vlad, Paula Grigorescu Sido, Simona Bucerzan, Camelia Al-Khzouz, Ioana Naşcu and Eugen Pascal Ciofu

ABSTRACT

Background and aims. Children with trisomy 21 have an increased risk of hematological anomalies. The aim of the study was to evaluate the hematological characteristics of these patients and to correlate them with the cytogenetic findings.

Material and method. We conducted an observational study on 136 patients with trisomy 21 that were evaluated recording a complete hematological picture. The individual parameters for each patient were compared with reference values for age and were statistically evaluated considering the age groups and the cytogenetic anomalies.

Results. In 91.2% of the cases the diagnosis of regular trisomy 21 was established. 58.08% of patients had at least one hematological anomaly. 8.82% and 2.2% associated 2 or 3 anomalies respectively. No differences regarding the hematological parameters were found between patients with regular trisomy 21, mosaic or a combination of anomalies. 16.9% of patients presented with a form of anemia: macrocytic anemia and iron deficiency anemia 5.14% each. A tendency to lower than normal leukocyte counts for all age groups was recorded. The patients associated thrombocytopenia and thrombocytosis with the same frequency (3.67%). 1.47% developed acute leukemia.

Conclusions. 58% of patients in all age groups and 100% of newborns with trisomy 21 had at least one hematological anomaly. The most frequent were leukopenia (17.61%), anemia (16.91%) and macrocytosis (16.91%). No significant differences were found in relation to the cytogenetic diagnosis.

Key words: trisomy 21, hematological changes

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Raluca Maria Vlad

MODIFICARI HEMATOLOGICE LA PACIENTII CU TRISOMIE 21

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Revista Romana de PEDIATRIE | Volumul LXII, Nr. 2, An 2013
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

MODIFICARI HEMATOLOGICE LA PACIENTII CU TRISOMIE 21

Raluca Maria Vlad, Paula Grigorescu Sido, Simona Bucerzan, Camelia Al-Khzouz, Ioana Naşcu and Eugen Pascal Ciofu

REZUMAT

Obiective. Pacienţii cu trisomie 21 au risc crescut de anomalii hematologice. Studiul şi-a propus evaluarea caracteristicilor hematologice ale acestor pacienţi şi corelarea lor cu modificările citogenetice. Material şi metodă. Am efectuat un studiu observaţional pe 136 pacienţi cu trisomie 21 evaluaţi hematologic. Rezultatele individuale au fost interpretate în funcţie de valorile normale pentru vârstă şi au fost prelucrate statistic pe grupe de vârstă şi în funcţie de modificările citogenetice constatate. Rezultate. În 91,2% dintre cazuri s-a stabilit diagnosticul de trisomie 21 omogenă. 58,08% au prezentat cel puţin o anomalie hematologică. 8,82% şi 2,2% au asociat câte 2, respectiv 3 anomalii. Nu s-au evidenţiat diferenţe între parametrii hematologici ai pacienţilor cu trisomie 21 omogenă şi cei cu mozaicism sau combinaţii de anomalii. 16,91% au prezentat o formă de anemie: macrocitară şi feriprivă în procente egale (5,14%). S-a constatat tendinţa la valori mai scăzute ale leucocitelor pentru toate vârstele. Pacienţii au asociat trombocitopenie şi trombocitoză cu aceeaşi frecvenţă (3,67%). 1,47% au dezvoltat leucemie acută. Concluzii. 58% dintre pacienţii de toate vârstele şi 100% dintre nou-născuţii cu trisomie 21 au prezentat cel puţin o anomalie hematologică. Cele mai frecvente anomalii hematologice constatate au fost leucopenia (17,61%), anemia (16,91%) şi macrocitoza (16,91%). Nu au existat diferenţe ale parametrilor hematologici în funcţie de modificările citogenetice.

Cuvinte cheie: trisomia 21, modificări hematologice

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Raluca Maria Vlad


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