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Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 2, An 2015
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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BISPHOSPHONATE THERAPY IN PEDIATRIC PATIENTS WITH OSTEOGENESIS IMPERFECTA

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ABSTRACT

Osteogenesis imperfecta (OI) is a group of rare inherited disorders of connective tissue with the common feature of excessive fragility of bones caused by mutations in collagen. We present the case of 2 patients diagnosed with different types of OI, both males, one admitted in the neonatal period and one in infancy. The aim of the study was to compare the efficiency of bisphosphonate therapy, following up the quality of life after receiving it, or in the absence of this treatment.

Keywords: osteogenesis imperfecta, bisphosphonates, child

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