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Sorina Paşc

Latest posts by Sorina Paşc (see all)

  • Prophylaxis with Palivizumab in infants with congenital heart disease - 23/07/2015
  • PROFILAXIA CU PALIVIZUMAB LA SUGARII CU MALFORMATII CARDIACE CONGENITALE - 23/07/2015

Articole semnate de acelasi autor in Revista Romana de Pediatrie:

Prophylaxis with Palivizumab in infants with congenital heart disease

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Revista Romana de PEDIATRIE | Volumul LXII, Nr. 2, An 2013
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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Prophylaxis with Palivizumab in infants with congenital heart disease

Amalia Făgărăşan, Carmen Şuteu, Iolanda Muntean, Liliana Gozar, Sorina Paşc, Balás Réka Borka and Rodica Toganel

ABSTRACT

Introduction. Human respiratory syncytial virus infections in children suffering from congenital heart disease is a primary cause of cardiac decompensation, which leads to frequent and prolonged hospitalizations. We will be sharing our department’s experience with utilizing Palivizumab in newborns and infants with hemodynamically significant congenital heart diseases.

Methods. According to recommendations made by immune prophylaxis guides regarding Palivizumab, 28 children with mean age 2,6 months hospitalized in the Cardiology Clinic II- Children, of the County Emergency Clinical Hospital in Tîrgu Mureş were included in a vaccination program between October 2010 and February 2012. The administered dose was 15 mg/kg (monthly intramuscular injection). Each child treated with Palivizumab was monitored in order to establish the hospitalization rate for respiratory infections, as well as detect any adverse reactions. A control group of 28 children, with a mean age of 4,3 months, with severe CHD was selected. The rate of respiratory infections was observed. The case group was monitored for 6 months after vaccination and the rate of bronchyolitis was observed.

Results. The hospitalization rate for respiratory infection was 3,57% in the case group, and 32% in the control group. Monitoring the side effects after vaccination showed no severe adverse reactions: 19% of the children developed subfebrility and slight anxiety and 4% developed fever and diarrhea 24 hours after administration.

Conclusion. The results show a favorable response to the vaccine, with minor side effects, an absence of hemodynamic decompensation at the time of administration, as well as a reduced number of human respiratory syncytial virus infections.

Key words: congenital heart disease, Palivizumab, infant

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Amalia Făgărăşan

PROFILAXIA CU PALIVIZUMAB LA SUGARII CU MALFORMATII CARDIACE CONGENITALE

SELECT ISSUE

Revista Romana de PEDIATRIE | Volumul LXII, Nr. 2, An 2013
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

PROFILAXIA CU PALIVIZUMAB LA SUGARII CU MALFORMATII CARDIACE CONGENITALE

Amalia Făgărăşan, Carmen Şuteu, Iolanda Muntean, Liliana Gozar, Sorina Paşc, Balás Réka Borka and Rodica Toganel

REZUMAT

Introducere. Infecţiile respiratorii cauzate de virusul sinciţial respirator la copiii cu malformaţii cardiace congenitale reprezintă o importantă cauză de decompensare, care determină spitalizări repetate, cu durată prelungită. Prezentăm experienţa centrului nostru privind utilizarea profilactică a Palivizumab la copiii sub 24 de luni, internaţi cu malformaţii cardiace congenitale semnificative hemodinamic. Material şi metodă. În conformitate cu recomandările ghidurilor privind profilaxia cu Palivizumab, 28 de copii cu vârsta medie de 2,6 luni, internaţi în Clinica Cardiologie II Copii a Spitalului Clinic Judeţean de Urgenţă Târgu-Mureş, au fost incluşi în programul de vaccinare, în perioada octombrie 2010 – februarie 2012. Pe perioada spitalizării s-au monitorizat parametrii hemodinamici, s-a notat orice reacţie adversă apărută, precum şi rata infecţiilor respiratorii. Părinţii au semnat un consimţământ informat privind acordul pentru vaccinare. A fost selectat un grup control care nu a beneficiat de vaccin (28 copii, vârsta medie 4,3 luni), urmărindu-se rata infecţiilor respiratorii pe perioada derulării programului. La lotul imunizat am monitorizat rata îmbolnăvirilor respiratorii 6 luni postimunizare. Rezultate. Rata îmbolnăvirilor respiratorii la lotul imunizat a fost de 3,57%, iar la lotul control 32%. Efectele secundare postvaccinare: 18% au prezentat subfebrilitate şi uşoară iritabilitate, iar 4% febră şi diaree la 24 de ore după administrare. La lotul imunizat nu au apărut decompensări hemodinamice. Concluzii. Efectele secundare postvaccinare au fost minore, nu au apărut decompensări hemodinamice, iar rata de îmbolnăvire postimunizare a fost redusă.

Cuvinte cheie: malformaţii cardiace congenitale, Palivizumab, sugar

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Amalia Făgărăşan


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