Articole semnate de acelasi autor in Revista Romana de Pediatrie:

GLIOAMELE CAILOR OPTICE IN NEUROFIBROMATOZA DE TIP 1 LA COPIL

Revista Romana de PEDIATRIE | Volumul LXIII, Nr. 1, An 2014

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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Ramona Filipescu, Ion Poeata, Ioana Grigore and Georgeta Diaconu

REZUMAT

Gliomul de căi optice are expresie clinică maximă în copilărie, în jurul vârstei de 5 ani, fiind a doua tumoră ca frecvenţă în neurofibromatoza tip 1. Topografic se descriu 3 tipuri de glioame de căi optice: tipul I – glioame retrobulbare prechiasmatice, tipul II – glioame de tract optic şi tipul III – glioame chiasmatice. Examenele neuroimagistice sunt esenţiale în stabilirea diagnosticului şi a indicaţiei neurochirurgicale. Managementul acestor tumori este dificil chiar dacă au caracteristici histopatologice benigne. Pacienţii cu glioame de nerv optic simptomatice şi progresie documentată neuroimagistic au indicaţie de rezecţie tumorală. Glioamele de nerv optic aso ciate neurofibromatozei tip 1 au în general o evoluţie bună, factorii de prognostic nefavorabil fiind reprezentaţi de debutul clinic precoce, sub vârsta de 6 ani şi de afectarea chiasmatică şi retrochiasmatică.

Cuvinte cheie: gliom de căi optice, neurofibromatoză tip 1, copil

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Ramona Filipescu

THE OPTIC PATHWAYS GLIOMAS IN CHILDREN WITH NEUROFIBROMATOSIS 1

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

Ramona Filipescu, Ion Poeata, Ioana Grigore and Georgeta Diaconu

ABSTRACT

Optic pathways gliomas have the maximal clinical expression in childhood around the age of 5, being the second tumor in neurofibromatosis type 1 in frequency. Considering their location,it describes three types of optic pathways gliomas: type I - retrobulbar gliomas, type II - optic tracts gliomas and type III - chiasmatic gliomas. Neuroimaging exams are essential in diagnosis and selection surgical patients. Management of these tumors is often difficult even they exhibit histological benign features. Patients harboring optic nerve gliomas with symptomatic and documented neuroimaging progression have indication of tumor resection. Optic nerve gliomas associated with neurofibromatosis type 1 have generally a good prognosis. Unfavorable prognostic factors are represented by the early clinical onset under 6 years of age and chiasmatic and retrochiasmatic location.

Keywords: optic pathways gliomas, neurofibromatosis type 1, children

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Ramona Filipescu