National Awards “Science and Research”
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Selective IgA deficiency and allergic diseases
Objectives. Review of literature data on the association of DSIgA with allergic diseases.
Materials and methods. We studied PubMed medical database, and from a total of 99 articles published between 1973-2011 20 articles were selected as being significant for the association.
Results. The first studies on this association goes back over 35 years. Studies published during this time cite association with asthma, atopic dermatitis, allergic rhinitis/conjunctivitis, urticaria, drug and food allergies and transfusion anaphylaxis. Sometimes, the relationship between allergic diseases and DSIgA can be bidirectional, as in allergic rhinitis or atopic dermatitis. Sometimes DSIgA can even represent an aggravating factor in allergic disease.
Conclusions. Although the literature offers few data on the association of these diseases, respiratory allergies and atopic dermatitis appear to be more common in patients with DSIgA. Some studies even claim DSIgA aggravating effect in these diseases. Association with celiac disease and transfusion anaphylaxis should not be neglected. Allergic manifestations may be those that determine the patient to the doctor, so a significant percentage of DSIgA is detected during allergology appointments.
Key words: immunodeficiency, selective IgA deficiency, allergy, asthma, atopic dermatitis