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Andra Caragheorgheopol

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Articole semnate de acelasi autor in Revista Romana de Pediatrie:

PROPEPTIDUL AMINO-TERMINAL AL PROCOLAGENULUI TIP I LA PACIENTII CU DEFICIT DE HORMON DE CRESTERE IN PERIOADA DE TRANZITIE

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Revista Romana de PEDIATRIE | Volumul LXV, Nr. 3, An 2016
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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PROPEPTIDUL AMINO-TERMINAL AL PROCOLAGENULUI TIP I LA PACIENTII CU DEFICIT DE HORMON DE CRESTERE IN PERIOADA DE TRANZITIE

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REZUMAT

Introducere. Achiziţia de masă osoasă continuă şi după atingerea taliei finale în perioada de tranziţie. Deficitul de hormon de creştere (GHD) pare să aibă un efect semnificativ asupra turnover-ului colagenului în timpul copilăriei şi mai puţin în timpul maturităţii. Propeptidul amino terminal al colagenului tip I (P1NP) este un marker de formare osoasă cu variabilitate intraindividuală scăzută faţă de IGF1.
Subiecţi şi metodă. 17 pacienţi de sex masculin diagnosticaţi în timpul copilăriei cu GHD, retestaţi în perioada de tranziţie, au fost evaluaţi la minimum 3 luni de la întreruperea tratamentului cu GH. Am evaluat corelaţia P1NP cu IGF1. Am determinat puterea predictivă a P1NP în identificarea pacienţilor cu deficit de GH persistent.
Rezultate. Am găsit o corelaţie pozitivă puternică între P1NP şi IGF-1 în grupul de pacienţi care au menţinut deficitul de GH în perioada de adult tânăr (r = 0,72, CI [0,02 la 0,94], p = 0,046). O valoare prag pentru P1NP de - 0,66 SDS prezice persistenţa deficitului de GH cu o sensibilitate de 62,5% CI [24,5 la 91,5], specificitate de 75% CI [47,6 la 92,7] şi AUC = 0,719 CI [0,5 la 0,881], p<0,05. Nu am găsit o diferenţă semnificativă atunci când am comparat AUC pentru cei 2 parametri (p = 0.29).
Concluzii. În perioada de tranziţie, atunci când viteza de creştere nu mai este disponibilă, dinamica P1NP în timpul terapiei substitutive cu GH ar putea fi utilă în cuantificarea eficienţei tratamentului.

Cuvinte cheie: Markeri de colagen, P1NP, IGF1, hormon de creştere, deficit de GH, perioada de tranziţie

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THE AMINO-TERMINAL PROPEPTIDE OF TYPE I PROCOLLAGEN IN GROWTH HORMONE-DEFICIENT PATIENTS DURING TRANSITION PERIOD

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Revista Romana de PEDIATRIE | Volumul LXV, Nr. 3, An 2016
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

THE AMINO-TERMINAL PROPEPTIDE OF TYPE I PROCOLLAGEN IN GROWTH HORMONE-DEFICIENT PATIENTS DURING TRANSITION PERIOD

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ABSTRACT

Introduction. Bone mineral accretion continues beyond the attainment of final height during the transition period. Growth hormone deficiency (GHD) appears to have a significant effect on collagen turnover during childhood and less during adulthood. Amino-terminal propeptide of type I collagen (P1NP) is a marker of bone formation with low intra-individual when comparing to IGF1.
Material and method. We evaluated 17 male patients diagnosed with GHD during childhood, after retesting GH axis in their transition period after at least 3 months from GH withdrawal. We correlate concentrations of P1NP and IGF1. We determined the predictive value for P1NP in identifying persistent GHD.
Results. We found a strong positive correlation between IGF-1 and P1NP in the group of patients who maintained GH deficiency as young adults (r = 0.72, CI [0.02 to 0.94], p = 0.046). A threshold value for the P1NP of - 0.66 SDS predicts persistence of GHD with a sensitivity of 62.5% CI [24.5 to 91.5], specificity 75% CI [47.6 to 92.7] and AUC = 0.719 CI [0.5 0881]. We did not find a significant difference when we compared the AUC for the two parameters (p = 0.29).
Conclusion. During the transition period, when the growth velocity is not available anymore, the dynamics of P1NP may be useful in quantifying the effectiveness of GH replacement therapy.

Keywords: Collagen markers, P1NP, growth hormone, IGF1, transition period, persistent GHD

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