Therapeutical effect of bisoprolol on the heart rate variability in children with mitral valve prolapse

Revista Romana de PEDIATRIE | Volumul LXI, Nr. 4, An 2012

ISSN 1454-0398 | e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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Lilia Romanciuc and Ninel Revenco

ABSTRACT

The following reasearch was made upon 50 children, age between 7 and 18 years, with mitral valve prolapse (MVP) of I and II stage: the first reasearch group includes 30 children (average age 12.93±0.52 years) that have been administared bisoprolol with the average dose 1,25-2,5/mg/24 h and the second research group, (average dose 13,55±0,60 years) that received placebo. The research results revealed that the mitral valve prolapse has been associated with different symptoms as cardiac pains (90%) and palpitation (88%). The action of bisoprolol on the parameters of heart rate variability has been established by the decreased value of the statistics and spectral indexes that show the activity of the sympathetic vegetative nervous system. The bisoprolol can be recommended to children with symptomatic MVP while being a cardioselective remedie with a high selectivity index (1:75).

Key words: bisoprolol,heart rate variability, mitral valve prolapse

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