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Mariana Moiceanu

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Articole semnate de acelasi autor in Revista Romana de Pediatrie:

CORELATIA DINTRE VALOAREA FENO SI SEVERITATEA ASTMULUI BRONSIC

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Revista Romana de PEDIATRIE | Volumul LXIII, Nr. 3, An 2014
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

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CORELATIA DINTRE VALOAREA FENO SI SEVERITATEA ASTMULUI BRONSIC

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REZUMAT

Obiectiv. Studiul de faţă îşi propune evaluarea corelaţiei dintre valoare FeNO şi severitatea astmului bronşic.

Material şi metodă. A fost iniţiat un studiu prospectiv care a inclus 48 de copii cu vârsta cuprinsă între 5-18 ani diagnosticaţi cu astm bronşic. Pacienţii au fost evaluaţi şi monitorizaţi în Clinica de Pediatrie din Spitalul Clinic de Copii „Dr. Victor Gomoiu“ în perioada mai 2012 – noiembrie 2013. În prima etapă, o dată cu stabilirea diagnosticului de astm bronşic, s-a stabilit şi forma de severitate, utilizând criteriile din ghidul GINA 2008, şi s-a determinat valoarea FeNO înainte de iniţierea oricărei terapii de control. Pentru formele persistente s-a iniţiat terapia de control adaptată astfel încât să se obţină starea de astm bronşic controlat. În etapa următoare, dupa publicarea ultimei versiuni a ghidului GINA 2014, s-a efectuat o a doua clasificare a astmului pe grade de severitate, ţinând cont de step-ul de tratament necesar pentru a menţine starea de astm controlat, conform recomandărilor din acest nou ghid. În final s-a evaluat corelaţia dintre valoarea FeNO şi severitatea formelor de astm, atât după clasificarea din ghidul GINA 2008, cât şi dintre valoarea FeNO şi severitatea formelor de astm după clasificarea din ghidul GINA 2014.

Rezultate. Dintre cei 48 de copii incluşi în studiu, 29 au avut valoarea FeNO normală, iar 19 crescută. Pe baza criteriilor ghidului GINA 2008 pacienţii au fost încadraţi în următoarele forme de severitate: 6 pacienţi cu astm intermitent, 27 pacienţi cu astm uşor persistent, 14 pacienţi cu astm moderat persistent şi 1 pacient cu astm sever persistent. Pe baza criteriilor din ultimul ghid GINA publicat în 2014, în formă de astm uşor au fost încadraţi 25 de pacienţi, în formă de astm moderat 22 de pacienţi, iar în formă de astm sever 1 pacient. Evaluarea statistică a corelaţiei dintre forma de astm bronşic conform criteriilor aparţinând ghidului GINA din 2008 şi valoarea FeNO a furnizat o valoare p = 0,278, iar corelaţia dintre valoarea FeNO şi clasificarea regăsită în ghidul GINA 2014 a fost de p = 0,0468.

Concluzii. Valoarea FeNO nu se corelează cu severitatea astmului bronşic stabilită pe baza clasificării din ghidul GINA 2008, dar se corelează cu severitatea astmului stabilită pe baza clasificării din ghidul GINA din 2014.

Cuvinte cheie: astm bronşic, severitate, FeNO, formă astm bronşic

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CORRELATION BETWEEN FENO VALUE AND ASTHMA SEVERITY

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Revista Romana de PEDIATRIE | Volumul LXIII, Nr. 3, An 2014
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

CORRELATION BETWEEN FENO VALUE AND ASTHMA SEVERITY

, and

ABSTRACT

Objective. The purpose of this study is to assess the correlation between the FeNO (fractional exhaled nitric oxide) value and asthma severity.

Material and method. A prospective study including 48 children aged 5 to 18 years, who have been diagnosed with asthma in „Victor Gomoiu” Children Clinical Hospital between May 2012 – November 2013, has been initiated. In the first stage of the study both the diagnosis and the degree of severity of asthma, using GINA 2008 guideline criteria, have been established, and the FeNO value has been measured before beginning any controller therapy. For the persistent asthma forms the controller therapy has been initiated, adapted to provide the controlled asthma status. In the next stage, after GINA 2014 guideline was published, a second classification of asthma, based on the degree of severity, has been performed, by taking into account the treatment step necessary to maintain the controlled asthma status, according to this new guide. Finally the correlation between FeNO value and the degree of asthma severity has been assessed, using first the asthma classification from GINA 2008 guideline and then the asthma classifi cation from GINA 2014 guideline.

Results. Among those 48 children included in the study 29 had normal FeNO value and 19 elevated FeNO value. According to GINA 2008 guideline criteria they have been included in the following severity asthma forms: 6 patients intermittent asthma, 27 patients mild persistent asthma, 14 patients moderate persistent asthma and 1 patient severe persistent asthma. According to GINA 2014 guideline criteria 25 patients have been labeled as mild asthma, 22 as moderate asthma and 1 as severe asthma. The statistic assessment of the correlation between asthma severity form according to GINA 2008 guideline and FeNO value provided a value of p = 0,278 and for the correlation between FeNO value and asthma severity form according to GINA 2014 guideline provided a value of p = 0,0468.

Conclusion. FeNO value is not correlated with asthma severity as resulted from GINA 2008 guideline classification, but is correlated with asthma severity as resulted from GINA 2014 guideline classification.

Keywords: asthma, severity, FeNO, asthma form

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