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Lilia Romanciuc

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Articole semnate de acelasi autor in Revista Romana de Pediatrie:

Therapeutical effect of bisoprolol on the heart rate variability in children with mitral valve prolapse

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Revista Romana de PEDIATRIE | Volumul LXI, Nr. 4, An 2012
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

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Therapeutical effect of bisoprolol on the heart rate variability in children with mitral valve prolapse

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ABSTRACT

The following reasearch was made upon 50 children, age between 7 and 18 years, with mitral valve prolapse (MVP) of I and II stage: the first reasearch group includes 30 children (average age 12.93±0.52 years) that have been administared bisoprolol with the average dose 1,25-2,5/mg/24 h and the second research group, (average dose 13,55±0,60 years) that received placebo. The research results revealed that the mitral valve prolapse has been associated with different symptoms as cardiac pains (90%) and palpitation (88%). The action of bisoprolol on the parameters of heart rate variability has been established by the decreased value of the statistics and spectral indexes that show the activity of the sympathetic vegetative nervous system. The bisoprolol can be recommended to children with symptomatic MVP while being a cardioselective remedie with a high selectivity index (1:75).

Key words: bisoprolol,heart rate variability, mitral valve prolapse

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EFECTUL BISOPROLOLULUI ASUPRA INDICILOR VARIABILITATII RITMULUI CARDIAC LA COPIII CU PROLAPS DE VALVA MITRALA

SELECT ISSUE

Revista Romana de PEDIATRIE | Volumul LXI, Nr. 4, An 2012
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

EFECTUL BISOPROLOLULUI ASUPRA INDICILOR VARIABILITATII RITMULUI CARDIAC LA COPIII CU PROLAPS DE VALVA MITRALA

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REZUMAT

Studiul a fost efectuat pe un lot de 50 copii, cu vârsta cuprinsă între 7 şi 18 ani, cu PVM gradul I şi gradul II: I lot de bază a inclus 30 de copii (vârsta medie 12,93±0,52 ani) cărora li s-a administrat bisoprolol în doza uzuală 1,25-2,5/mg/24 ore şi lotul II lotul martor (vârsta medie 13,55±0,60 ani), care au primit placebo. Rezultatele studiului au prezentat asocierea prolapsului de valvă mitrală cu diverse simptome clinice, cu predominarea durerilor precordiale (90%) şi a palpitaţiilor (88%). Acţiunea bisoprololului asupra parametrilor variabilităţii ritmului cardiac s-a exprimat prin micşorarea indicilor statistici şi spectrali caracteristici pentru activitatea sistemului nervos vegetativ simpatic. Bisoprololul poate fi recomandat în schema de tratament la copii cu PVM simptomatic, fiind un preparat cardioselectiv cu indice de selectivitate înalt (1:75).

Cuvinte cheie: neoplazie, terapie intensivă, copil

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