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Extradigestive manifestations of Helicobacter pylori infection in children
The role of Helicobacter pylori bacteria in the pathogenesis of the digestive diseases now, is very well established and known, but recent research claims that Helicobacter pylori is involved in producing some extra-digestive diseases. The prevalence of the infection differs from one geographical area to another, registering a descending trend in developed countries and remaining at a constant level or even increasing in developing countries. Helicobacter pylori determines an immune response of the host, which involves humor and cell immunity. The infection is located in the gastric mucosa, but in recent years we have seen studies that try to explain some allergic diseases as the consequence, at least in some patients, of the chronic infection with Helicobacter pylori. The gastro-intestinal sufferings caused by the infection with H. pylori manifested by nausea, vomiting, anorexia, epigastric pains can be associated with nutritional disorders. Many recent studies prove that the infection with H. pylori is associated with anemia, and weight loss. Helicobacter pylori was identifi ed in most diabetic patients with autoimmune neuropathy, causing electric gastric disorders, the delay of the stomach evacuation, manifestations responsible of the dyspeptic symptoms in diabetic patients. The appropriate therapeutic behavior in the case of patients with extra-digestive affections and an eventual infection with H. pylori should concern both the basic disease treatment and the effi cient eradication of the infection.
Key words: Helicobacter pylori, extradigestive manifestations, child.
Presedintele Societatii Romane de Pediatrie