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Diana Goran

Latest posts by Diana Goran (see all)

  • HEMORAGIA PERI-INTRAVENTRICULARA LA PREMATURI: IMPORTANTA SCREENINGULUI PRIN ECOGRAFIE TRANSFONTANELARA - 21/07/2015
  • PERI-INTRAVENTRICULAR HEMORRHAGE IN PRETERM INFANTS: THE IMPORTANCE OF SCREENING BY TRANSFONTANELLAR ULTRASOUND - 21/07/2015
  • MALFORMATIE CEREBRALA EXTREMA – CONSIDERATII CLINICE SI ETICE PE MARGINEA UNUI CAZ - 21/07/2015

Articole semnate de acelasi autor in Revista Romana de Pediatrie:

HEMORAGIA PERI-INTRAVENTRICULARA LA PREMATURI: IMPORTANTA SCREENINGULUI PRIN ECOGRAFIE TRANSFONTANELARA

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Revista Romana de PEDIATRIE | Volumul LXII, Nr. 4, An 2013
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

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HEMORAGIA PERI-INTRAVENTRICULARA LA PREMATURI: IMPORTANTA SCREENINGULUI PRIN ECOGRAFIE TRANSFONTANELARA

Mirela Elena Ritivoiu, Florin Nicolaie Brezan, Cosmina Cristea, Ioana Codreanu, Diana Goran, Lucica Ghita and Ioana Alina Anca

ABSTRACT

Obiective. Hemoragiile peri-intraventriculare (HPIV) pot determina la sugarii născuţi prematur diferite grade de re tard neuropsihomotor. Un studiu prospectiv efectuat în IOMC pe o perioadă de 4 ani (2009-2012), pe un lot de 160 prematuri, a urmărit prevalenţa gradelor de HPIV diagnosticate prin ecografie transfontanelară (ETF), identificarea factorilor de risc asociaţi şi a severităţii afectării neurologice la aceşti pacienţi prin urmărirea lor pe o perioadă de 12 luni.

Material şi metodă. Pe perioada studiului, prematurii internaţi în IOMC au fost examinaţi sistematic prin ETF, printr-un protocol standardizat; aprecierea gradelor HPIV s-a efectuat conform clasificării Papile. Evaluarea neurologică a fost efectuată sistematic până la vârsta de 1 an.

Rezultate. Cel mai frecvent înregistrate au fost HPIV I şi II – 45%, respectiv 37,5% din numărul total de pacienţi. HPIV gradul IV au reprezentat 4,4%. În HPIV grad I şi II afectarea neurologică a fost uşoară, această corelaţie având semnificaţie statistică (p < 0,01) pentru ambele forme. Hemoragiile gradul III şi IV au fost asociate cu o evoluţie neurologică nefavorabilă, corelaţia între HPIV grad IV şi sechelele neurologice majore având semnificaţie statistică (p < 0,01).

Concluzii. ETF efectuată de rutină tuturor prematurilor permite diagnosticul precoce şi stadializarea HPIV, aprecierea evoluţiei neurologice cu instituirea precoce a tratamentului şi asigurarea consilierii adecvate.

Cuvinte cheie: prematur, ecografie transfontanelară, hemoragie peri-intraventriculară, prognostic neurologic

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Mirela Elena Ritivoiu

PERI-INTRAVENTRICULAR HEMORRHAGE IN PRETERM INFANTS: THE IMPORTANCE OF SCREENING BY TRANSFONTANELLAR ULTRASOUND

SELECT ISSUE

Revista Romana de PEDIATRIE | Volumul LXII, Nr. 4, An 2013
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

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DOAJ
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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

PERI-INTRAVENTRICULAR HEMORRHAGE IN PRETERM INFANTS: THE IMPORTANCE OF SCREENING BY TRANSFONTANELLAR ULTRASOUND

Mirela Elena Ritivoiu, Florin Nicolaie Brezan, Cosmina Cristea, Ioana Codreanu, Diana Goran, Lucica Ghita and Ioana Alina Anca

ABSTRACT

Objectives. In preterm babies, peri-intraventricular hemorrahges (PIVH) might cause various degrees of neuropsycho-motor impairment. A 4-year prospective study (2009-2012) performed in the IOMC, was aimed to determine the prevalence of different degrees of PIVH diagnosed by head ultrasound (HUS) among 160 admitted preterm babies, the associated risk factors, along with the neuro-developmental effects on a 12-month follow-up period.

Material and methods. In the above-mentioned period all admitted preterms were examined by transfontanelar ultrasound according to a standardized protocol based on Papile’s PIVH classification. For those preterms included in the study a 12-month systematic neurologic follow-up was performed. Results. PIVH grade I (45%) and II (37,5%) were the most prevalent types. Grade IV PIVH represented 4,4% from all PIVH cases. The good neurological outcome of grade I and II PIVH, was found to be statistically significant (p < 0.01) for both types. Severe neurological sequelae were associated with grade III and IV and a statistically significant correlation (p<0.01) was found only for grade IV hemorrhages.

Conclusion. Systematic HUS screenings for all preterm babies is useful for early diagnosis and PIVH staging, for neurologic outcome prediction, providing the appropriate management strategy and a well-suited parental counseling.

Key words: preterm, transfontanelar ultrasound, peri-intraventricular hemorrhage, neurological outcome

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Mirela Elena Ritivoiu

MALFORMATIE CEREBRALA EXTREMA – CONSIDERATII CLINICE SI ETICE PE MARGINEA UNUI CAZ

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Revista Romana de PEDIATRIE | Volumul LXIII, Nr. 4, An 2014
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

MALFORMATIE CEREBRALA EXTREMA – CONSIDERATII CLINICE SI ETICE PE MARGINEA UNUI CAZ

Florin Brezan, Ioana Codreanu, Rodica Cretu, Lucica Ghita, Mirela Ritivoiu, Diana Goran and Ioana Alina Anca

REZUMAT

Hidranencefalia reprezintă una dintre malformaţiile cerebrale extrem de rară şi cu prognostic nefavorabil, cu impact psihoafectiv negativ asupra familiei şi societăţii. În mod obişnuit, cei afectaţi rămân într-o stare vegetativă permanentă şi necesită îngrijiri pe termen nelimitat. Deşi majoritatea celor afectaţi decedează în primele zile-luni de viaţă, o parte dintre ei supravieţuiesc până în decada a 2-a a 3-a de viaţă. Din punct de vedere al tratamentului, îngrijirile acordate sunt pur paliative şi sunt îndreptate spre menţinerea funcţiilor vitale.

Concluzii. Hidranencefalia reprezintă o malformaţie cerebrală rară, cu prognostic rezervat şi speranţă de viaţă şi calitate a vieţii scăzute. Diagnosticul impune o serie de probleme etice. Importanţa diagnosticului prenatal se impune prin faptul că hidranencefaliare prezintă indicaţie de avort terapeutic. O altă problemă etică o ridică îngrijirile medicale acordate, ce sunt pur paliative, pacienţii fiind în stare vegetativă permanentă. Atât instituirea tratamentului chirurgical pentru drenajul cantităţii excesive al LCR, cât şi metodele noi terapeutice descrise în literatură, de tipul coagulării endoscopice a plexurilor choroide, nu influenţează statusul neurologic şi dezvoltarea neuropsihomotorie a pacienţilor. Toate aceste date trebuie explicate clar aparţinătorilor, pentru a nu-şi ridica speranţe false în ceea ce priveşte evoluţia acestor bolnavi.

Cuvinte cheie: hidranencefalie, ecografie transfontanelară, hemoragie periintraventriculară, prematuritate

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Florin Brezan

SIMPTOMATOLOGIA ALERGIEI LA PROTEINELE LAPTELUI DE VACA IN POPULATIA PEDIATRICA – STUDIU RETROSPECTIV

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Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 2, An 2015
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

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DOAJ
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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

SIMPTOMATOLOGIA ALERGIEI LA PROTEINELE LAPTELUI DE VACA IN POPULATIA PEDIATRICA – STUDIU RETROSPECTIV

Netta Katry, Anca Ladaru, Diana Goran, Alexandra Ana-Maria Zotta and Ioana Alina Anca

REZUMAT

Introducere. Metaanalize recente bazate pe studii populaţionale relevă o heterogenitate considerabilă în prevalenţa reacţiilor alergice suspicionate şi confirmate, precum şi în sensibilizarea la ingestia de lapte de vacă. Reacţiile adverse apărute la consumul laptelui de vacă au şabloane diferite de prevalenţă în funcţie de grupa de vârstă interesată. Există un interes public în creştere în ceea ce priveşte adevarata prevalenţă şi posibilitatea unei creşteri a apariţiei alergiilor alimentare în timp, cu precădere în rândul părinţilor şi al persoanelor implicate în îngrijirea şi educarea copiilor precum şi în rândul personalului medical şi al producatorilor de alimente.

Materiale şi metodă. Am derulat un studiu retrospectiv pe un lot de copii internaţi în clinica de pediatrie a IOMC „Alfred Rusescu“ Bucureşti în perioada cuprinsă între ianuarie 2011 şi mai 2013. Obiectivul principal al studiului a fost de a analiza şi compara reacţiile alergice alimentare la copiii internaţi în Clinica de Pediatrie IOMC cu rezultatele găsite de alte grupuri de cercetare.

Rezultate. Din 312 pacienţi evaluaţi prin panelul alimentar pediatric la 20 de alergeni, 64 au fost IgE pozitivi pentru proteinele laptelui de vacă.

Discuţii. Am stabilit că simptomele associate reacţiilor adverse la lapte sunt frecvente în rândul sugarilor şi apar indiferent de vârsta gestaţională la naştere sau de genul copilului. Aşa cum era de aşteptat am descoperit că cei mai mulţi dintre copiii diagnosticati cu APLV proveneau din mediul urban. Simptomele debuteaza adesea în timpul primului an de viaţă, chiar şi la copiii alimentaţi exclusiv natural. Semnele şi simptomele importante de alarmă în cadrul APLV observate au fost falimentul creşterii, anemia carenţială, precum şi simptomatologia digestivă şi respiratorie.

Cuvinte cheie: alergia la proteinele laptelui de vacă, falimentul creşterii

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Netta Katry

SYMPTOMS OF COW MILK PROTEIN ALLERGY IN CHILDREN – A RETROSPECTIVE STUDY

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Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 2, An 2015
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
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NLM Catalog
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

SYMPTOMS OF COW MILK PROTEIN ALLERGY IN CHILDREN – A RETROSPECTIVE STUDY

Netta Katry, Anca Ladaru, Diana Goran, Alexandra Ana-Maria Zotta and Ioana Alina Anca

ABSTRACT

Introduction. Recent meta-analyses of population-based studies show considerable heterogeneity in the prevalence of perceived and confirmed allergic reactions, as well as sensitization to cow milk ingestion. Adverse reactions to cow milk ingestion have different prevalence patterns in different age groups. There is increasing public concern about the true prevalence and a possible increase of food allergies over time, particularly among parents, child care and school staff, health care providers, regulators and food producers.

Materials and methods. We performed a retrospective study of children admitted in IOMC hospital in Bucharest between January 2011 to May 2013. The primary aim of this study was to establish and compare the prevalence of confirmed allergic reactions to food in young children from IOMC hospital to known symptoms established by different researches.

Results. 312 patients were evaluated with IgE panel blood test, 64 were IgE positive to cow milk protein fraction.

Discussion. We found that symptoms of adverse reactions to milk are common in infants and occur regardless of GA at birth or sex. As expected, we found that more children with CMA where living in urban than rural areas. The symptoms often appear during the first year of life, even in exclusively breastfed children. Important signs and symptoms to alarm CMA were found to be failure to thrive, anemia, gastrointestinal and respiratory complains.

Keywords: cow milk protein allergy, failure to thrive

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Netta Katry

EXTREME CEREBRAL MALFORMATION – CLINICAL AND ETHICAL ISSUES BASED ON A CASE

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Revista Romana de PEDIATRIE | Volumul LXIII, Nr. 4, An 2014
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJP has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

EXTREME CEREBRAL MALFORMATION – CLINICAL AND ETHICAL ISSUES BASED ON A CASE

Florin Brezan, Ioana Codreanu, Rodica Cretu, Lucica Ghita, Mirela Ritivoiu, Diana Goran and Ioana Alina Anca

ABSTRACT

Hydranencephaly represents one of the most rare cerebral malformations, with poor prognosis and negative impact on both family and society. Usually the patients remain in a permanent vegetative state and require unlimited medical care. Although the majority of affected babies die in utero or in the fi rst days-months of life there have been cases in literature with prolonged survival, for 20 (1), 22 (2) and 32 (3) years. Therapeutically, the medical care provided are purely palliative and oriented to supporting vital function.

Conclusions. Hydranencephaly is a rare brain malformation with poor prognosis, life expectancy and quality of life. Diagnosis imposes a number of ethical issues. The importance resides in the fact that prenatal detection represents an indication for therapeutic abortion. Another ethical issue raised is represented by medical care provided, which is exclusively palliative. Both surgical and novel therapeutic methods described by the literature, like endoscopic coagulation of choroid plexes, do not infl uence the neurological status and the neuropsychomotordevelopment (4). All this data should be clearly explained to parents and legal tutors for not raising any false hopes regarding the evolution.

Keywords: hydranencephaly, transfontanellar ultrasound, peri/intraventricular hemorrhage, prematurity

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Florin Brezan


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