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Anca Cabat

Latest posts by Anca Cabat (see all)

  • TULBURARE DE MIGRARE NEURONALA – CAZ CLINIC - 23/11/2015
  • NEURONAL MIGRATION DISORDER – A CLINICAL CASE - 23/11/2015
  • TOXICOMANIA IN SARCINA – FACTOR DE RISC PENTRU INFECTIE PERINATALA - 20/07/2015

Articole semnate de acelasi autor in Revista Romana de Pediatrie:

TULBURARE DE MIGRARE NEURONALA – CAZ CLINIC

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Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 3, An 2015
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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TULBURARE DE MIGRARE NEURONALA – CAZ CLINIC

Carmen Voicila, Anca Cabat and Raluca Gabriela Ioan

REZUMAT

Autorii prezintă cazul unui nou-născut transferat la 43 h de la naştere în Clinica de Neonatologie IOMC Polizu pentru sindrom de detresă respiratorie neonatală şi suspiciune de infecţie materno-fetală, care a fost investigat extensiv pe parcursul internării pentru persistenţa tulburărilor de tonus muscular neexplicate printr-o asfixie la naştere, fiind diagnosticat în urma examenului RMN cu heterotopie periventriculară dreaptă asociată cu chist porencefalic temporal stâng şi schizencefalie de aceeaşi parte.

Cuvinte cheie: heterotopie corticală, RMN, hipotonie de cauză centrală

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Carmen Voicila

NEURONAL MIGRATION DISORDER – A CLINICAL CASE

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Revista Romana de PEDIATRIE | Volumul LXIV, Nr. 3, An 2015
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Ebsco Host - Medline
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Semantic Scholar

HIGHLIGHTS

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

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NEURONAL MIGRATION DISORDER – A CLINICAL CASE

Carmen Voicila, Anca Cabat and Raluca Gabriela Ioan

ABSTRACT

The authors present the case of a newborn transferred to the Neonatology Section of IOMC Polizu, 43 hours after birth suffering from syndrome of neonatal respiratory distress and suspicion of maternal – fetal infection, extensively investigated during hospitalization for persistency of muscle tone disorder which could not be explained by asphyxia at birth, diagnosed after MRI with right periventricular heterotopia associated with left temporal porencephalic cyst and schizencephaly on the same side.

Keywords: cortical heterotopia, MRI, central cause hypotony

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Carmen Voicila

TOXICOMANIA IN SARCINA – FACTOR DE RISC PENTRU INFECTIE PERINATALA

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Revista Romana de PEDIATRIE | Volumul LXIII, Nr. 2, An 2014
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

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TOXICOMANIA IN SARCINA – FACTOR DE RISC PENTRU INFECTIE PERINATALA

Doina Broscauncianu, Silvia Maria Stoicescu, Gabriel Banceanu and Anca Cabat

REZUMAT

Introducere. Infecţiile neonatale sunt cauze majore de morbiditate şi mortalitate neonatală. Toxicomania prin injectarea de droguri ilicite este un important factor de risc pentru infecţii perinatale. Obiectivul studiului a fost evaluarea incidenţei infectiilor cu debut precoce la nou-născuţi proveniţi din sarcini cu risc de infecţie perinatală: sarcini neinvestigate, marcate de toxicomanie şi sarcini investigate clinico-paraclinic.

Material şi metodă. Studiu retrospectiv care a cuprins nou-născuţi în Institutul pentru Ocrotirea Mamei şi Copilului, Spitalul Clinic de Obstetrică-Ginecologie „POLIZU”, grupaţi în 2 loturi: un lot de 25 nou-născuţi în perioada 2005-2012 proveniţi din sarcini neinvestigate survenite la femei consumatoare de droguri ilicite şi un lot de 50 nou-născuţi proveniţi din sarcini corect investigate anamnestico-clinic cu factori de risc pentru infecţie perinatală. Datele au fost analizate statistic (teste specifice de corelaţie: Student T, Fisher exact, Chi-square).

Rezultate. Incidenţa nou-născuţilor din sarcini marcate de toxicomanie a fost de 0,09% din totalul de 28.489 naşteri, cu o maximă de 0,2% înregistrată în anul 2011. Diferenţe semnificativ statistic s-au înregistrat între cele două loturi de nou-născuţi cu factori de risc infecţios prezent în privinţa: vârstei mamelor – mai mică la toxicomane (p_value = 0,0002) a procentului de infecţii congenitale (p_value = 0,00003) OR = 0,03; 95%CI precum şi a duratei medii (zile) de spitalizare (p_value = 0,0180) mai mari la nou-născuţi ai mamelor cu toxicomanie, dar şi în privinţa modului de naştere prin cezariană (p_value = 0,0010) a colonizării bacteriene a tractului uro-genital matern (p_value = 0,0016) mai frecvente la nou-născuţi proveniţi din sarcini investigate. 22% din femeile însărcinate investigate, au prezentat Streptococ grup B, cel mai frecvent tip fiind serotipul Ib. Ponderea, în cadrul morbidităţii neonatale, a infecţiilor perinatale a fost pentru nou-născuţi din mame toxicomane de 33%, iar pentru nou-născuţi proveniţi din sarcini investigate de 27%. Incidenţa infecţiei perinatale a fost de 52% la nou-născuţi din mame toxicomane (risc de infecţie de 1/1,9 cazuri) şi de 18% la nou-născuţi din sarcini supravegheate (ceea ce reprezintă un risc de 1/5,5 cazuri).

Concluzii. Toxicomania în cursul sarcinii constituie, prin boli infecţioase dobândite pe cale sexuală sau sanguină asociate cu deficienţe de igienă pe fond de nutriţie precară şi de imunitate scăzută, un important factor de risc pentru infecţie perinatală. Asistenţa sanitară în cursul sarcinii, prin diagnostic şi tratament precoce al infecţiei materne, poate diminua incidenţa şi consecinţele medico-sociale ale infecţiei neonatale.

Cuvinte cheie: toxicomanie în sarcină, factor de risc, infecţie perinatală

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Doina Broscauncianu

DRUG ADDICTION DURING PREGNANCY – RISK FACTOR FOR PERINATAL INFECTIONS

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Revista Romana de PEDIATRIE | Volumul LXIII, Nr. 2, An 2014
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398
DOI: 10.37897/RJP

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

Partners

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DRUG ADDICTION DURING PREGNANCY – RISK FACTOR FOR PERINATAL INFECTIONS

Doina Broscauncianu, Silvia Maria Stoicescu, Gabriel Banceanu and Anca Cabat

ABSTRACT

Introduction. Neonatal infections are a major causes of neonatal morbidity and mortality. Pregnancy complicated by illicit drug abuse is a risk for perinatal infection.

Objective. To assess the incidence of early-onset neonatal sepsis (the first 7 days of life) in newborns from high-risk pregnancies for perinatal infections: the ones affected by drug abuse, without medical assistance versus clinical and fully investigated pregnancies.

Material and methods. Retrospective study on newborns from “IOMC – Emergency Clinical Hospital of Obstetrics and Gynaecology Gh Polizu”, Bucharest, sorted in two separate groups: one of 25 newborns, from 2005 to 2012, coming from uninvestigated pregnancies in women with illicit drug dependencies and another of 50 newborns from properly managed pregnancies from the clinical and anamnestic point of view, but with known risk factors for perinatal infections. The data has been statistically analysed (correlation tests: Student T, Fisher exact, chi-square)

Results. The incidence of newborns from pregnancies affected by drug abuse was 0,09% in all 28489 newborns, the highest percentage of 0,2% being recorded in 2011. Statistically significant differences between the two groups of newborns with risk factors for perinatal infections (emerged from uninvestigated pregnancies with drug abuse and respectively from investigated pregnancies) were: the age of the mothers – lower in drug addicted mothers (p_value 0,0002), the percentage of congenital infections (p_value 0,00003; OR 0,03; 95%CI) and respectively the mean length of hospital stay-days (p_value0,0180) higher in dug addicted mothers. On the other hand: the delivery by cesarean section (p_value 0,0010), urogenital colonisation (p_value 0,0016) were more frequent in newborns from investigated pregnancies. A percent of 22 of all investigated women were positive for Group B Streptococcus and the most frequent type was I b type. The share of perinatal infections among neonatal morbidity was 33% for the newborns from drug addicted mothers and 27% for the newborns from investigated mothers. The incidence of neonatal infections was 52% for the newborns from drug addicted mothers (a risk of 1 in 1,9 cases) and 18% for the newborns from investigated mothers (a risk of 1 in 5,5 cases)

Conclusions. Drug addiction during pregnancy represents a high risk factor for perinatal infections due to sexual and blood transmitted diseases associated with lack of hygiene, precarious nutrition and low immunological status and leads to high medical and social costs. The correct medical management of pregnancies, through early diagnosis and treatment of neonatal infections may lower the incidence and the consequences of perinatal infections.

Keywords: risk factors, perinatal infection, fallow up of pregnancy, maternal drug abuse

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Doina Broscauncianu


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