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Revista Romana de PEDIATRIE | Volumul LXII, Nr. 4, An 2013
ISSN 1454-0398  |  e-ISSN 2069-6175
ISSN-L 1454-0398

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GENETIC FACTORS OF SEPSIS IN CHILDREN

ABSTRACT

The genetic fingerprint holds a major relevance in the apparition, evolution and prognosis of infections. The paper focuses on polymorphisms for one nucleotide (SNPs) of the genes which encode proteins with the main role in recognizing pathogens (Toll-like receptors: TLR2, TLR4, TLR5) or in the inflammatory response (TNFα, IL6, IL10) and which determine the severity and the type of the infection. The allelic configuration constitutes an important risk element for corioamniotitis, prematurity, sepsis and death. It can also be a growth factor in resistance to common infections. Post-septic immunodepression influences late mortality of children who have suffered from infectious shock.

Key words: genetic polymorphism, infections, death risk

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